Discovery of os cordis in the cardiac skeleton of chimpanzees (Pan troglodytes)

Moitti�, Sophie; Baiker, Kerstin; Strong, Victoria; Cousins, Emma; White, Kate; Liptovszky, M�ty�s; Redrobe, Sharon; Alibhai, Aziza; Sturrock, Craig J.; Rutland, Catrin Sian

Abstract

© 2020, The Author(s). Cardiovascular diseases, especially idiopathic myocardial fibrosis, is one of the most significant causes of morbidity and mortality in captive great apes. This study compared the structure and morphology of 16 hearts from chimpanzees (Pan troglodytes) which were either healthy or affected by myocardial fibrosis using X-ray microtomography. In four hearts, a single, hyperdense structure was detected within the right fibrous trigone of the cardiac skeleton. High resolution scans and histopathology revealed trabecular bones in two cases, hyaline cartilage in another case and a focus of mineralised fibro-cartilaginous metaplasia with endochondral ossification in the last case. Four other animals presented with multiple foci of ectopic calcification within the walls of the great vessels. All hearts affected by marked myocardial fibrosis presented with bone or cartilage formation, and increased collagen levels in tissues adjacent to the bone/cartilage, while unaffected hearts did not present with os cordis or cartilago cordis. The presence of an os cordis has been described in some ruminants, camelids, and otters, but never in great apes. This novel research indicates that an os cordis and cartilago cordis is present in some chimpanzees, particularly those affected by myocardial fibrosis, and could influence the risk of cardiac arrhythmias and sudden death.

Citation

Moittié, S., Baiker, K., Strong, V., Cousins, E., White, K., Liptovszky, M., Redrobe, S., Alibhai, A., Sturrock, C. J., & Rutland, C. S. (2020). Discovery of os cordis in the cardiac skeleton of chimpanzees (Pan troglodytes). Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-66345-7

• Journal Article Type: Article
• Acceptance Date: May 4, 2020
• Online Publication Date: Jun 10, 2020
• Publication Date: Dec 1, 2020
• Deposit Date: May 5, 2020
• Publicly Available Date: Jun 10, 2020
• Journal: Scientific Reports
• Electronic ISSN: 2045-2322
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 1
• DOI: https://doi.org/10.1038/s41598-020-66345-7
• Public URL: https://nottingham-repository.worktribe.com/output/4383461
• Publisher URL: https://www.nature.com/articles/s41598-020-66345-7
• Additional Information: Moittié, S., Baiker, K., Strong, V., Cousins, E., White, K., Liptovszky, M., …Rutland, C. S. (2020). Discovery of os cordis in the cardiac skeleton of chimpanzees (Pan troglodytes). Scientific Reports, https://doi.org/10.1038/s41598-020-66345-7