Skip to main content

Research Repository

Advanced Search

Developing a self-healing supramolecular nucleoside hydrogel

Skilling, Kathryn J.; Kellam, Barrie; Ashford, M.; Bradshaw, Tracey D.; Marlow, Maria

Authors

Kathryn J. Skilling

Barrie Kellam

M. Ashford

Tracey D. Bradshaw

Maria Marlow



Abstract

Low molecular weight gelator hydrogels provide a viable alternative to traditional polymer based drug delivery platforms, owing to their tunable stability and in most cases inherent biocompatibility. Here we report the first self-healing nucleoside hydrogel using N4-octanoyl-2′-deoxycytidine (0.5% w/v) for drug delivery. The hydrogel's cross-linked nanofibrillar structure, was characterised using oscillatory rheology and confirmed using SEM and TEM imaging. The potential of this gel for drug delivery was explored in vitro using fluorescently labelled tracers. Cell viability assays were conducted using pancreatic cell lines which tolerated the gels well; whilst no adverse effects on the viability or proliferation of cells were observed for fibroblast cell lines.

Journal Article Type Article
Journal Soft Matter
Print ISSN 1744-683X
Electronic ISSN 1744-6848
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
APA6 Citation Skilling, K. J., Kellam, B., Ashford, M., Bradshaw, T. D., & Marlow, M. (in press). Developing a self-healing supramolecular nucleoside hydrogel. Soft Matter, doi:10.1039/C6SM01779G
DOI https://doi.org/10.1039/C6SM01779G
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2016/SM/C6SM01779G#!divAbstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

Files

RSC Soft Matter Paper_Revised Manuscript_final for publishing.pdf (674 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





You might also like



Downloadable Citations

;