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Developing a self-healing supramolecular nucleoside hydrogel

Skilling, K. J.; Kellam, B.; Ashford, M.; Bradshaw, Tracey D.; Marlow, Maria

Developing a self-healing supramolecular nucleoside hydrogel Thumbnail


K. J. Skilling

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Professor of Medicinal Chemistry

M. Ashford

Tracey D. Bradshaw


© 2016 The Royal Society of Chemistry. Low molecular weight gelator hydrogels provide a viable alternative to traditional polymer based drug delivery platforms, owing to their tunable stability and in most cases inherent biocompatibility. Here we report the first self-healing nucleoside hydrogel using N4-octanoyl-2′-deoxycytidine (0.5% w/v) for drug delivery. The hydrogel's cross-linked nanofibrillar structure, was characterised using oscillatory rheology and confirmed using SEM and TEM imaging. The potential of this gel for drug delivery was explored in vitro using fluorescently labelled tracers. Cell viability assays were conducted using pancreatic cell lines which tolerated the gels well; whilst no adverse effects on the viability or proliferation of cells were observed for fibroblast cell lines.

Journal Article Type Article
Acceptance Date Sep 19, 2016
Online Publication Date Sep 21, 2016
Publication Date Nov 21, 2016
Deposit Date Oct 4, 2016
Publicly Available Date Oct 4, 2016
Journal Soft Matter
Print ISSN 1744-683X
Electronic ISSN 1744-6848
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 12
Issue 43
Pages 8950-8957
Public URL
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