Passerini chemistries for synthesis of polymer pro-drug and polymersome drug delivery nanoparticles

Travanut, Alessandra; Monteiro, Patrícia F.; Smith, Sean; Howdle, Steven M.; Grabowska, Anna M.; Kellam, Barrie; Meier, Michael A.R.; Alexander, Cameron

Abstract

New materials chemistries are urgently needed to overcome the limitations of existing biomedical materials in terms of preparation, functionality and versatility, and also in regards to their compatibility with biological environments. Here, we show that Passerini reactions are especially suited for the preparation of drug delivery materials, as with relatively few steps, polymers can be synthesized with functionality installed enabling drug conjugation and encapsulation, self-assembly into micellar or vesicular architectures, and with facile attachment triggerable chemistries. The polymers can be made with a variety of building blocks and assemble into nanoparticles, which are rapidly internalized in triple negative breast cancer (TNBC) cells. In addition, the polymers transport drug molecules efficiently through 3D cell cultures, and when designed with chemistries allowing pH-mediated release, exhibit greater efficacy against TNBC cells compared to the parent drug.

Citation

Travanut, A., Monteiro, P. F., Smith, S., Howdle, S. M., Grabowska, A. M., Kellam, B., …Alexander, C. (2022). Passerini chemistries for synthesis of polymer pro-drug and polymersome drug delivery nanoparticles. Journal of Materials Chemistry B, 10, 3895-3905. https://doi.org/10.1039/d2tb00045h

• Journal Article Type: Article
• Acceptance Date: Apr 16, 2022
• Online Publication Date: Apr 19, 2022
• Publication Date: May 28, 2022
• Deposit Date: Jun 28, 2022
• Publicly Available Date: Jun 29, 2022
• Journal: Journal of Materials Chemistry B
• Print ISSN: 2050-750X
• Electronic ISSN: 2050-7518
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Pages: 3895-3905
• DOI: https://doi.org/10.1039/d2tb00045h
• Keywords: General Materials Science; Biomedical Engineering; General Chemistry; General Medicine
• Public URL: https://nottingham-repository.worktribe.com/output/7839653
• Publisher URL: https://pubs.rsc.org/en/content/articlelanding/2022/TB/D2TB00045H