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Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers

Adlington, Kevin; Nguyen, Nam T.; Eaves, Elizabeth; Yang, Jing; Chang, Chien Yi; Li, Jianing; Gower, Alexandra L.; Stimpson, Amy; Anderson, Daniel G.; Langer, Robert; Davies, Martyn C.; Hook, Andrew L.; Williams, Paul; Alexander, Morgan R.; Irvine, Derek J.

Authors

Kevin Adlington

Nam T. Nguyen

Elizabeth Eaves

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JING YANG JING.YANG@NOTTINGHAM.AC.UK
Assistant Professor

Chien Yi Chang

Jianing Li

Alexandra L. Gower

Daniel G. Anderson

Robert Langer

Martyn C. Davies

ANDREW HOOK ANDREW.HOOK@NOTTINGHAM.AC.UK
Nottingham Research Fellow

PAUL WILLIAMS paul.williams@nottingham.ac.uk
Professor of Molecular Microbiology

DEREK IRVINE derek.irvine@nottingham.ac.uk
Professor of Materials Chemistry



Abstract

© 2016 American Chemical Society. Developing medical devices that resist bacterial attachment and subsequent biofilm formation is highly desirable. In this paper, we report the optimization of the molecular structure and thus material properties of a range of (meth)acrylate copolymers which contain monomers reported to deliver bacterial resistance to surfaces. This optimization allows such monomers to be employed within novel coatings to reduce bacterial attachment to silicone urinary catheters. We show that the flexibility of copolymers can be tuned to match that of the silicone catheter substrate, by copolymerizing these polymers with a lower Tg monomer such that it passes the flexing fatigue tests as coatings upon catheters, that the homopolymers failed. Furthermore, the Tg values of the copolymers are shown to be readily estimated by the Fox equation. The bacterial resistance performance of these copolymers were typically found to be better than the neat silicone or a commercial silver containing hydrogel surface, when the monomer feed contained only 25 v% of the "hit" monomer. The method of initiation (either photo or thermal) was shown not to affect the bacterial resistance of the copolymers. Optimized synthesis conditions to ensure that the correct copolymer composition and to prevent the onset of gelation are detailed.

Citation

Adlington, K., Nguyen, N. T., Eaves, E., Yang, J., Chang, C. Y., Li, J., …Irvine, D. J. (2016). Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers. Biomacromolecules, 17(9), 2830-2838. https://doi.org/10.1021/acs.biomac.6b00615

Journal Article Type Article
Acceptance Date Jul 26, 2016
Online Publication Date Aug 26, 2016
Publication Date Sep 12, 2016
Deposit Date Jun 20, 2018
Publicly Available Date Jun 20, 2018
Journal Biomacromolecules
Print ISSN 1525-7797
Electronic ISSN 1526-4602
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 17
Issue 9
Pages 2830-2838
DOI https://doi.org/10.1021/acs.biomac.6b00615
Public URL http://eprints.nottingham.ac.uk/id/eprint/52535
Publisher URL https://pubs.acs.org/doi/10.1021/acs.biomac.6b00615
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
Additional Information This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright © 2016 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.biomac.6b00615.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf


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