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Abnormal visuomotor processing in schizophrenia

Robson, Siân E.; Brookes, Matthew J.; Hall, Emma L.; Palaniyappan, Lena; Kumar, Jyothika; Skelton, Michael; Christodoulou, Nikolaos G.; Qureshi, Ayaz; Jan, Fiesal; Katshu, Mohammad Z.; Liddle, Elizabeth B.; Liddle, Peter F.; Morris, Peter G.

Authors

Siân E. Robson

Emma L. Hall

Lena Palaniyappan

Jyothika Kumar

Michael Skelton

Nikolaos G. Christodoulou

Ayaz Qureshi

Fiesal Jan

Mohammad Z. Katshu

Elizabeth B. Liddle

Peter F. Liddle



Abstract

Subtle disturbances of visual and motor function are known features of schizophrenia and can greatly impact quality of life; however, few studies investigate these abnormalities using simple visuomotor stimuli. In healthy people, electrophysiological data show that beta band oscillations in sensorimotor cortex decrease during movement execution (event-related beta desynchronisation (ERBD)), then increase above baseline for a short time after the movement (post movement beta rebound (PMBR)); while in visual cortex, gamma oscillations are increased throughout stimulus presentation. In this study, we used a selfpaced visuomotor paradigm and magnetoencephalography (MEG) to contrast these responses in patients with schizophrenia and control volunteers. We found significant reductions in the peak-to-peak change in amplitude from ERBD to PMBR in schizophrenia compared with controls. This effect was strongest in patients who made fewer movements, whereas beta was not modulated by movement in controls. There was no significant difference in the amplitude of visual gamma between patients and controls. These data demonstrate that clear abnormalities in basic sensorimotor processing in schizophrenia can be observed using a very simple MEG paradigm

Citation

Robson, S. E., Brookes, M. J., Hall, E. L., Palaniyappan, L., Kumar, J., Skelton, M., …Morris, P. G. (2016). Abnormal visuomotor processing in schizophrenia. NeuroImage: Clinical, 12, 869-878. https://doi.org/10.1016/j.nicl.2015.08.005

Journal Article Type Article
Acceptance Date Aug 13, 2015
Online Publication Date Sep 25, 2015
Publication Date 2016-02
Deposit Date Mar 23, 2016
Publicly Available Date Mar 23, 2016
Journal NeuroImage: Clinical
Electronic ISSN 2213-1582
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 12
Pages 869-878
DOI https://doi.org/10.1016/j.nicl.2015.08.005
Keywords Schizophrenia, magnetoencephalography, motor cortex, visual cortex, electrophysiological processes
Public URL http://eprints.nottingham.ac.uk/id/eprint/32487
Publisher URL http://www.sciencedirect.com/science/article/pii/S2213158215001436
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
Additional Information This article is maintained by: Elsevier; Article Title: Abnormal visuomotor processing in schizophrenia; Journal Title: NeuroImage: Clinical; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.nicl.2015.08.005; Content Type: article; Copyright: © 2016 The Authors. Published by Elsevier Inc.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0






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