Abnormal visuomotor processing in schizophrenia

Robson, Si�n E.; Brookes, Matthew J.; Hall, Emma L.; Palaniyappan, Lena; Kumar, Jyothika; Skelton, Michael; Christodoulou, Nikolaos G.; Qureshi, Ayaz; Jan, Fiesal; Katshu, Mohammad Z.; Liddle, Elizabeth B.; Liddle, Peter F.; Morris, Peter G.

Abstract

Subtle disturbances of visual and motor function are known features of schizophrenia and can greatly impact quality of life; however, few studies investigate these abnormalities using simple visuomotor stimuli. In healthy people, electrophysiological data show that beta band oscillations in sensorimotor cortex decrease during movement execution (event-related beta desynchronisation (ERBD)), then increase above baseline for a short time after the movement (post movement beta rebound (PMBR)); while in visual cortex, gamma oscillations are increased throughout stimulus presentation. In this study, we used a selfpaced visuomotor paradigm and magnetoencephalography (MEG) to contrast these responses in patients with schizophrenia and control volunteers. We found significant reductions in the peak-to-peak change in amplitude from ERBD to PMBR in schizophrenia compared with controls. This effect was strongest in patients who made fewer movements, whereas beta was not modulated by movement in controls. There was no significant difference in the amplitude of visual gamma between patients and controls. These data demonstrate that clear abnormalities in basic sensorimotor processing in schizophrenia can be observed using a very simple MEG paradigm

Citation

Robson, S. E., Brookes, M. J., Hall, E. L., Palaniyappan, L., Kumar, J., Skelton, M., Christodoulou, N. G., Qureshi, A., Jan, F., Katshu, M. Z., Liddle, E. B., Liddle, P. F., & Morris, P. G. (2016). Abnormal visuomotor processing in schizophrenia. NeuroImage: Clinical, 12, 869-878. https://doi.org/10.1016/j.nicl.2015.08.005

• Journal Article Type: Article
• Acceptance Date: Aug 13, 2015
• Online Publication Date: Sep 25, 2015
• Publication Date: 2016-02
• Deposit Date: Mar 23, 2016
• Publicly Available Date: Mar 23, 2016
• Journal: NeuroImage: Clinical
• Electronic ISSN: 2213-1582
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 12
• Pages: 869-878
• DOI: https://doi.org/10.1016/j.nicl.2015.08.005
• Keywords: Schizophrenia, magnetoencephalography, motor cortex, visual cortex, electrophysiological processes
• Public URL: https://nottingham-repository.worktribe.com/output/760638
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S2213158215001436
• Additional Information: This article is maintained by: Elsevier; Article Title: Abnormal visuomotor processing in schizophrenia; Journal Title: NeuroImage: Clinical; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.nicl.2015.08.005; Content Type: article; Copyright: © 2016 The Authors. Published by Elsevier Inc.