A. L. Bosma
Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics
Bosma, A. L.; Ascott, A.; Iskandar, R.; Farquhar, K.; Matthewman, J.; Langendam, M. W.; Mulick, A.; Abuabara, K.; Williams, H. C.; Spuls, P. I.; Langan, S. M.; Middelkamp-Hup, M. A.
Authors
A. Ascott
R. Iskandar
K. Farquhar
J. Matthewman
M. W. Langendam
A. Mulick
K. Abuabara
Professor HYWEL WILLIAMS HYWEL.WILLIAMS@NOTTINGHAM.AC.UK
PROFESSOR OF DERMATO-EPIDEMIOLOGY
P. I. Spuls
S. M. Langan
M. A. Middelkamp-Hup
Abstract
Atopic dermatitis is a heterogeneous disease, accompanied by a wide variation in disease presentation and the potential to identify many phenotypes that may be relevant for prognosis and treatment. We aimed to systematically review previously reported phenotypes of atopic dermatitis and any characteristics associated with them. Ovid EMBASE, Ovid MEDLINE and Web of Science were searched from inception till 12 February 2021 for studies attempting to classify atopic dermatitis. Primary outcomes are atopic dermatitis phenotypes and characteristics associated with them in subsequent analyses. A secondary outcome is the methodological approach used to derive them. In total, 8511 records were found. By focussing only on certain clinical phenotypes, 186 studies were eligible for inclusion. The majority of studies were hospital-based (59%, 109/186) and cross-sectional (76%, 141/186). The number of included patients ranged from seven to 526 808. Data-driven approaches to identify phenotypes were only used in a minority of studies (7%, 13/186). Ninety-one studies (49%) investigated a phenotype based on disease severity. A phenotype based on disease trajectory, morphology and eczema herpeticum was investigated in 56 (30%), 22 (12%) and 11 (6%) studies respectively. Thirty-six studies (19%) investigated morphological characteristics in other phenotypes. Investigated associated characteristics differed between studies. In conclusion, we present an overview of phenotype definitions used in literature for severity, trajectory, morphology and eczema herpeticum, including associated characteristics. There is a lack of uniform and consistent use of atopic dermatitis phenotypes across studies.
Citation
Bosma, A. L., Ascott, A., Iskandar, R., Farquhar, K., Matthewman, J., Langendam, M. W., Mulick, A., Abuabara, K., Williams, H. C., Spuls, P. I., Langan, S. M., & Middelkamp-Hup, M. A. (2022). Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics. Journal of the European Academy of Dermatology and Venereology, 36(6), 807-819. https://doi.org/10.1111/jdv.18008
Journal Article Type | Review |
---|---|
Acceptance Date | Jan 18, 2022 |
Online Publication Date | Feb 25, 2022 |
Publication Date | Jun 1, 2022 |
Deposit Date | Jan 26, 2022 |
Publicly Available Date | Feb 26, 2023 |
Journal | Journal of the European Academy of Dermatology and Venereology |
Print ISSN | 0926-9959 |
Electronic ISSN | 1468-3083 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 36 |
Issue | 6 |
Pages | 807-819 |
DOI | https://doi.org/10.1111/jdv.18008 |
Public URL | https://nottingham-repository.worktribe.com/output/7340692 |
Publisher URL | https://onlinelibrary.wiley.com/doi/10.1111/jdv.18008 |
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Classifying Atopic Eczema Systematic Review Of Phenotypes And Associated Characteristics
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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