Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays

Hook, Andrew L.; Chang, Chien-Yi; Yang, Jing; Atkinson, Steve; Langer, Robert; Anderson, Daniel G.; Davies, Martyn C.; Williams, Paul; Alexander, Morgan R.

doi:10.1002/adma.201204936

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Authors

ANDREW HOOK ANDREW.HOOK@NOTTINGHAM.AC.UK
Assistant Professor

Chien-Yi Chang

JING YANG JING.YANG@NOTTINGHAM.AC.UK
Assistant Professor

STEVE ATKINSON steve.atkinson@nottingham.ac.uk
Associate Professor

Robert Langer

Daniel G. Anderson

Martyn C. Davies

PAUL WILLIAMS paul.williams@nottingham.ac.uk
Professor of Molecular Microbiology

MORGAN ALEXANDER morgan.alexander@nottingham.ac.uk
Professor of Biomedical Surfaces

Abstract

A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available silver hydrogel anti-bacterial material. The coverage of three bacterial species, Pseudomonas aeruginosa, Staphylococcus aureus, and uropathogenic Escherichia coli is assessed.

Citation

Hook, A. L., Chang, C., Yang, J., Atkinson, S., Langer, R., Anderson, D. G., …Alexander, M. R. (2013). Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays. Advanced Materials, 25(18), https://doi.org/10.1002/adma.201204936

Journal Article Type	Article
Publication Date	May 14, 2013
Deposit Date	Apr 15, 2014
Publicly Available Date	Apr 15, 2014
Journal	Advanced Materials
Print ISSN	0935-9648
Electronic ISSN	0935-9648
Publisher	Wiley
Peer Reviewed	Peer Reviewed
Volume	25
Issue	18
DOI	https://doi.org/10.1002/adma.201204936
Public URL	https://nottingham-repository.worktribe.com/output/715184
Publisher URL	http://onlinelibrary.wiley.com/doi/10.1002/adma.201204936/full