Daphne E. Mavrides
Antimicrobial resistance profiles of bacteria associated with lower respiratory tract infections in cats and dogs in England
Mavrides, Daphne E.; Morgan, Alice L.; Na, Jea G.; Graham, Peter A.; McHugh, Timothy D.
Authors
Alice L. Morgan
Jea G. Na
Dr PETER GRAHAM PETER.GRAHAM@NOTTINGHAM.AC.UK
Professor of Veterinary Clinical Pathology and Endocrinology
Timothy D. McHugh
Abstract
Background: Bacterial lower respiratory tract infections (bLRTIs) are common and potentially life threatening in cats and dogs. Antibiotic treatment is often initiated before the diagnosis of bLRTI; therefore improved knowledge of the aetiology and antibiotic susceptibility patterns of these infections is essential to inform empiric antibiotic choices. Methods: A retrospective study of microbiological, cytological results and their drug susceptibilities from lower respiratory samples (n=1989) processed in a UK commercial laboratory between 2002 and 2012 was carried out. Results: Thirty-nine per cent of feline samples and 50% of canine samples were positive for bacterial growth with most yielding a single organism (72 % and 69%, respectively). Bordetella bronchiseptica (20.2% from dogs and 2.3% from cats), Pasteurella spp. (23.2%, 31.8%), E. coli (16.2%, 13.6%) and Pseudomonas spp. (11.1%, 11.4%) were most frequently isolated from cytologically positive samples which contained intracellular bacteria (10%, 14%). Amoxycillin-clavulanate, cephalothin, cefovecin, oxytetracycline and trimethoprim/sulfamethoxazole showed modest in vitro activity against E. coli from dogs (approximately 70% susceptibility). Pseudomonas spp. were resistant to enrofloxacin (50%), ticarcillin (25%) and marbofloxacin (13%) but showed lower or zero resistance to aminoglycosides (approximately 7%) and ciprofloxacin (0%). Multi drug resistance (acquired resistance to three or more antimicrobial drug classes) was particularly common among E. coli isolates, with 23% from feline samples and 43% from canine samples. Conclusion: Resistance to certain first-choice antibiotics was detected in bLRTIs highlighting the need for continued monitoring and sound evidence to inform decision-making in the management of these infections.
Journal Article Type | Article |
---|---|
Acceptance Date | Jul 23, 2021 |
Online Publication Date | Aug 11, 2021 |
Publication Date | Feb 19, 2022 |
Deposit Date | Jul 26, 2021 |
Publicly Available Date | Aug 12, 2022 |
Journal | Veterinary Record |
Print ISSN | 0042-4900 |
Electronic ISSN | 2042-7670 |
Publisher | BMJ Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 190 |
Issue | 4 |
Article Number | e779 |
DOI | https://doi.org/10.1002/vetr.779 |
Public URL | https://nottingham-repository.worktribe.com/output/5833266 |
Publisher URL | https://bvajournals.onlinelibrary.wiley.com/doi/10.1002/vetr.779 |
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Aetiology of antimicrobial resistance in bacterial lower respiratory tract infections
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Publisher Licence URL
https://creativecommons.org/licenses/by-nc/4.0/
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