Nasal immunization with homogenate and peptide antigens induces protective immunity against Trichinella spiralis

McGuire, Carolann; Chan, Weng C.; Wakelin, Derek

Abstract

Mice were successfully immunized against the intestinal nematode Trichinella spiralis by intranasal administration of a 30-mer peptide antigen with cholera toxin B. Immunized mice developed antigen-specific serum immunoglobulin G1, intestinal immunoglobulin A, and a type 2-biased cytokine response. Intranasal immunization therefore generates the Th2-mediated responses required for immunity against intestinal parasites.

• Journal Article Type: Article
• Publication Date: Dec 1, 2002
• Deposit Date: May 12, 2023
• Journal: Infection and Immunity
• Print ISSN: 0019-9567
• Publisher: American Society for Microbiology
• Peer Reviewed: Peer Reviewed
• Volume: 70
• Issue: 12
• Pages: 7149-7152
• DOI: https://doi.org/10.1128/IAI.70.12.7149-7152.2002
• Public URL: https://nottingham-repository.worktribe.com/output/3137776
• Publisher URL: https://journals.asm.org/doi/10.1128/IAI.70.12.7149-7152.2002