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Outputs (328)

Short-acting β-agonist use as a marker of current asthma control (2013)
Journal Article
Patel, M., Pilcher, J., Munro, C., Hosking, A., Pritchard, A., Shaw, D., Black, P., Weatherall, M., & Beasley, R. (in press). Short-acting β-agonist use as a marker of current asthma control. Journal of Allergy and Clinical Immunology: In Practice, 1(4), https://doi.org/10.1016/j.jaip.2013.04.008

Background

The relationship between current asthma symptoms and rescue bronchodilator (reliever) use is uncertain, leading to different recommendations about the preferred reliever metric to use when assessing asthma control. In a 6-month randomiz... Read More about Short-acting β-agonist use as a marker of current asthma control.

Efficacy and safety of maintenance and reliever combination budesonide–formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial (2013)
Journal Article
Patel, M., Pilcher, J., Pritchard, A., Perrin, K., Travers, J., Shaw, D., Holt, S., Harwood, M., Black, P., Weatherall, M., & Beasley, R. (2013). Efficacy and safety of maintenance and reliever combination budesonide–formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial. Lancet Respiratory Medicine, 1(1), 32-42. https://doi.org/10.1016/S2213-2600%2813%2970007-9

Background
The Single combination budesonide–formoterol inhaler Maintenance And Reliever Therapy (SMART) regimen reduces severe asthma exacerbations in patients, but whether the high doses of corticosteroid and β agonist increase the risk of adverse... Read More about Efficacy and safety of maintenance and reliever combination budesonide–formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial.

Target renal damage: the microvascular associations of increased aortic stiffness in patients with COPD (2013)
Journal Article
John, M., Hussain, S., Prayle, A., Simms, R., Cockroft, J. R., & Bolton, C. E. (2013). Target renal damage: the microvascular associations of increased aortic stiffness in patients with COPD. Respiratory Research, 14(31), https://doi.org/10.1186/1465-9921-14-31

Background
Although renal impairment has been described in COPD, there is opportunity to evaluate further to determine nature and consider optimal management. Increased aortic stiffness, as seen in COPD, leads to reduced buffering of pulsatile flow.... Read More about Target renal damage: the microvascular associations of increased aortic stiffness in patients with COPD.

Use of metered-dose inhaler electronic monitoring in a real-world asthma randomized controlled trial (2012)
Journal Article
Patel, M., Pilcher, J., Travers, J., Perrin, K., Shaw, D., Black, P., Weatherall, M., & Beasley, R. (2013). Use of metered-dose inhaler electronic monitoring in a real-world asthma randomized controlled trial. Journal of Allergy and Clinical Immunology: In Practice, 1(1), https://doi.org/10.1016/j.jaip.2012.08.004

Background

Electronic monitoring of inhaled asthma medications is one method to measure medication adherence and patterns of use. Information on the performance of monitors in a randomized controlled trial allows researchers and clinicians to unde... Read More about Use of metered-dose inhaler electronic monitoring in a real-world asthma randomized controlled trial.

Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study (2012)
Journal Article
Forrester, D. L., Knox, A. J., Smyth, A. R., & Fogarty, A. W. (2013). Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study. Journal of Cystic Fibrosis, 12(3), https://doi.org/10.1016/j.jcf.2012.08.008

Background
Body habitus differences may explain some of the variation in lung function between individuals with cystic fibrosis (CF). We tested the hypothesis that measures of lean muscle mass and obesity are independently associated with lung funct... Read More about Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study.

Epigenetics and miRNA emerge as key regulators of smooth muscle cell phenotype and function (2012)
Journal Article
Clifford, R. L., Singer, C. A., & John, A. E. (2013). Epigenetics and miRNA emerge as key regulators of smooth muscle cell phenotype and function. Pulmonary Pharmacology and Therapeutics, 26(1), 75-85. https://doi.org/10.1016/j.pupt.2012.07.002

Regulation of phenotypic plasticity in smooth muscle requires an understanding of the mechanisms regulating phenotype-specific genes and the processes dysregulated during pathogenesis. Decades of study in airway smooth muscle has provided extensive k... Read More about Epigenetics and miRNA emerge as key regulators of smooth muscle cell phenotype and function.

Abnormal Histone Methylation Is Responsible for Increased Vascular Endothelial Growth Factor 165a Secretion from Airway Smooth Muscle Cells in Asthma (2012)
Journal Article
Clifford, R. L., John, A. E., Brightling, C. E., & Knox, A. J. (2012). Abnormal Histone Methylation Is Responsible for Increased Vascular Endothelial Growth Factor 165a Secretion from Airway Smooth Muscle Cells in Asthma. Journal of Immunology, 189(2), 819-831. https://doi.org/10.4049/jimmunol.1103641

Vascular endothelial growth factor (VEGF), a key angiogenic molecule, is aberrantly expressed in several diseases including asthma where it contributes to bronchial vascular remodeling and chronic inflammation. Asthmatic human airway smooth muscle ce... Read More about Abnormal Histone Methylation Is Responsible for Increased Vascular Endothelial Growth Factor 165a Secretion from Airway Smooth Muscle Cells in Asthma.