Outputs (328)

Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study (2015)
Journal Article
Jenkins, R. G., Simpson, J. K., Saini, G., Bentley, J. H., Russell, A.-M., Braybrooke, R., Molyneux, P. L., McKeever, T. M., Wells, A. U., Flynn, A., Hubbard, R. B., Leeming, D. J., Marshall, R. P., Karsdal, M. A., Lukey, P. T., & Maher, T. M. (2015). Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study. Lancet Respiratory Medicine, 3(6), https://doi.org/10.1016/s2213-2600%2815%2900048-x

BACKGROUND: Idiopathic pulmonary fibrosis, a progressive and inevitably fatal disorder, has a highly variable clinical course. Biomarkers that reflect disease activity are urgently needed to inform patient management and for use as biomarkers of ther... Read More about Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study.

αvβ6 integrin may be a potential prognostic biomarker in interstitial lung disease (2015)
Journal Article
Saini, G., Porte, J., Weinreb, P. H., Violette, S. M., Wallace, W. A., McKeever, T. M., & Jenkins, G. (2015). αvβ6 integrin may be a potential prognostic biomarker in interstitial lung disease. European Respiratory Journal, 46(2), 486-494. https://doi.org/10.1183/09031936.00210414

Idiopathic pulmonary fibrosis (IPF) and fibrotic nonspecific interstitial pneumonitis are progressive interstitial lung diseases (ILDs) with limited treatment options and poor survival. However, the rate of disease progression is variable, implying t... Read More about αvβ6 integrin may be a potential prognostic biomarker in interstitial lung disease.

A survey-based cross-sectional study of doctors’ expectations and experiences of non-technical skills for out of hours work (2015)
Journal Article
Brown, M., Shaw, D. E., Sharples, S., Le Jeune, I., & Blakey, J. (2015). A survey-based cross-sectional study of doctors’ expectations and experiences of non-technical skills for out of hours work. BMJ Open, 5(2), Article e006102. https://doi.org/10.1136/bmjopen-2014-006102

Objectives: The skill set required for junior doctors to work efficiently and safely Out of Hours (OoH) in hospitals has not been established. This is despite the OoH period representing 75% of the year and it being the time of highest mortality. We... Read More about A survey-based cross-sectional study of doctors’ expectations and experiences of non-technical skills for out of hours work.

Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. (2015)
Journal Article
John, M., Cockcroft, J. R., McKeever, T. M., Coward, W. R., Shale, D. J., Johnson, S. R., Thornton, J., Harrison, T. W., Knox, A. J., & Bolton, C. E. (2015). Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. International Journal of Chronic Obstructive Pulmonary Disease, 10(1), https://doi.org/10.2147/COPD.S76061

BACKGROUND:

There is excess cardiovascular mortality in patients with chronic obstructive pulmonary disease. Aortic stiffness, an independent predictor of cardiovascular risk, and systemic and airway inflammation are increased in patients with the... Read More about Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial..

The statistical geometry of transcriptome divergence in cell-type evolution and cancer (2015)
Journal Article
Liang, C., Consortium, F., Forrest, A. R., & Wagner, G. ̈. P. (2015). The statistical geometry of transcriptome divergence in cell-type evolution and cancer. Nature Communications, 6(1), Article 6066. https://doi.org/10.1038/ncomms7066

In evolution, body plan complexity increases due to an increase in the number ofindividualized cell types. Yet, there is very little understanding of the mechanisms thatproduce this form of organismal complexity. One model for the origin... Read More about The statistical geometry of transcriptome divergence in cell-type evolution and cancer.

The use of β2-agonist therapy before hospital attendance for severe asthma exacerbations: a post-hoc analysis (2015)
Journal Article
Patel, M., Pilcher, J., Hancox, R. J., Sheahan, D., Pritchard, A., Braithwaite, I., Shaw, D., Black, P., Weatherall, M., & Beasley, R. (2015). The use of β2-agonist therapy before hospital attendance for severe asthma exacerbations: a post-hoc analysis. npj Primary Care Respiratory Medicine, 25, 1-9. https://doi.org/10.1038/npjpcrm.2014.99

Background:
Patterns of inhaled β2-agonist therapy use during severe asthma exacerbations before hospital attendance are poorly understood.

Aims:
To assess β2-agonist use prior to hospital attendance.

Methods:
We undertook an exploratory pos... Read More about The use of β2-agonist therapy before hospital attendance for severe asthma exacerbations: a post-hoc analysis.

NMR imaging of low pressure, gas-phase transport in packed beds using hyperpolarized xenon-129 (2015)
Journal Article
Pavlovskaya, G., Six, J. S., Meersman, T., Gopinathan, N., & Rigby, S. P. (2015). NMR imaging of low pressure, gas-phase transport in packed beds using hyperpolarized xenon-129. AIChE Journal, 61(11), 4013-4019. https://doi.org/10.1002/aic.14929

© 2015 American Institute of Chemical Engineers. Gas-phase magnetic resonance imaging (MRI) has been used to investigate heterogeneity in mass transport in a packed bed of commercial, alumina, catalyst supports. Hyperpolarized 129Xe MRI enables study... Read More about NMR imaging of low pressure, gas-phase transport in packed beds using hyperpolarized xenon-129.

Genetic risk factors for the development of allergic disease identified by genome-wide association (2015)
Journal Article
Portelli, M. A., Hodge, E., & Sayers, I. (2015). Genetic risk factors for the development of allergic disease identified by genome-wide association. Clinical and Experimental Allergy, 45(1), https://doi.org/10.1111/cea.12327

An increasing proportion of the worldwide population is affected by allergic diseases such as allergic rhinitis (AR), atopic dermatitis (AD) and allergic asthma and improved treatment options are needed particularly for severe, refractory disease. Al... Read More about Genetic risk factors for the development of allergic disease identified by genome-wide association.

Exhaled nitric oxide and inhaled corticosteroid dose reduction in asthma: A cohort study (2014)
Journal Article
Meakin, G., Anderson, J., McKeever, T., Wilson, E., McKeever, T. M., Hargadon, B., Hearson, G., Anderson, J., Hodgson, D., Bailey, H., Meakin, G., Thomas, M., Pavord, I. D., Harrison, T. W., & Shaw, D. E. (2014). Exhaled nitric oxide and inhaled corticosteroid dose reduction in asthma: A cohort study. European Respiratory Journal, 44(6), 1705-1707. https://doi.org/10.1183/09031936.00093614

Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer (2014)
Journal Article
Mavrou, A., Brakspear, K., Hamdollah-Zadeh, M., Damodaran, G., Babaei-Jadidi, R., Oxley, J., Gillatt, D., Ladomery, M., Harper, S., Bates, D., & Oltean, S. (2015). Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer. Oncogene, 34(33), 4311-4319. https://doi.org/10.1038/onc.2014.360

Angiogenesis is required for tumour growth and is induced principally by vascular endothelial growth factor A (VEGF-A). VEGF-A pre-mRNA is alternatively spliced at the terminal exon to produce two families of isoforms, pro- and anti-angiogenic, only... Read More about Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer.