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Outputs (327)

Epigenetic dysregulation of interleukin 8 (CXCL8) hypersecretion in cystic fibrosis airway epithelial cells (2016)
Journal Article
Poghosyan, A., Patel, J. K., Clifford, R. L., & Knox, A. J. (2016). Epigenetic dysregulation of interleukin 8 (CXCL8) hypersecretion in cystic fibrosis airway epithelial cells. Biochemical and Biophysical Research Communications, 476(4), 431-437. https://doi.org/10.1016/j.bbrc.2016.05.140

Airway epithelial cells in cystic fibrosis (CF) overexpress Interleukin 8 (CXCL8) through poorly defined mechanisms. CXCL8 transcription is dependent on coordinated binding of CCAAT/enhancer binding protein (C/EBP)β, nuclear factor (NF)-κB, and activ... Read More about Epigenetic dysregulation of interleukin 8 (CXCL8) hypersecretion in cystic fibrosis airway epithelial cells.

A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation (2016)
Journal Article
Williams, N. C., Johnson, M. A., Shaw, D. E., Spendlove, I., Vulevic, J., Sharpe, G. R., & Hunter, K. A. (2016). A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation. British Journal of Nutrition, 116(5), 798-804. https://doi.org/10.1017/S0007114516002762

Gut microbes have a substantial influence on systemic immune function and allergic sensitisation. Manipulation of the gut microbiome through prebiotics may provide a potential strategy to influence the immunopathology of asthma. This study investigat... Read More about A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation.

Genes associated with polymorphic variants predicting lung function are differentially expressed during human lung development (2016)
Journal Article
Miller, S., Melén, E., Merid, S. K., Hall, I. P., & Sayers, I. (in press). Genes associated with polymorphic variants predicting lung function are differentially expressed during human lung development. Respiratory Research, 17(95), https://doi.org/10.1186/s12931-016-0410-z

Background
Recent meta-analyses of genome-wide association studies have identified single nucleotide polymorphisms (SNPs) within/near 54 genes associated with lung function measures. Current understanding of the contribution of these genes to human... Read More about Genes associated with polymorphic variants predicting lung function are differentially expressed during human lung development.

See I told you I was taking it! - attitudes of adolescents with asthma towards a device monitoring their inhaler use: Implications for future design (2016)
Journal Article
Howard, S., Lang, A. R., Sharples, S., & Shaw, D. E. (2017). See I told you I was taking it! - attitudes of adolescents with asthma towards a device monitoring their inhaler use: Implications for future design. Applied Ergonomics, 58, 224-237. https://doi.org/10.1016/j.apergo.2016.06.018

Adherence to treatment in asthma is often poor, particularly in adolescents and children where the condition is most prevalent. Electronic monitoring devices have shown potential for improving inhaler use, yet little research has considered the attit... Read More about See I told you I was taking it! - attitudes of adolescents with asthma towards a device monitoring their inhaler use: Implications for future design.

Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease (2016)
Journal Article
Selvarajah, S., Todd, I., Tighe, P. J., John, M., Bolton, C. E., Harrison, T. W., & Fairclough, L. C. (2016). Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease. Mediators of Inflammation, 2016, 1-9. https://doi.org/10.1155/2016/3604842

Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal. To investigate this, we developed a protein microarray system to detect multipl... Read More about Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease.

Untargeted metabolic profiling of saliva by liquid chromatography-mass spectrometry for the identification of potential diagnostic biomarkers of asthma (2016)
Journal Article
Malkar, A., Wilson, E., Harrison, T., Shaw, D. E., & Creaser, C. (in press). Untargeted metabolic profiling of saliva by liquid chromatography-mass spectrometry for the identification of potential diagnostic biomarkers of asthma. Analytical Methods, 8(27), 5407-5413. https://doi.org/10.1039/C6AY00938G

Current clinical tests employed to diagnose asthma are inaccurate and limited by their invasive nature. New metabolite profiling technologies offer an opportunity to improve asthma diagnosis using non-invasive sampling. A rapid analytical method for... Read More about Untargeted metabolic profiling of saliva by liquid chromatography-mass spectrometry for the identification of potential diagnostic biomarkers of asthma.

Trends in hospital admissions for hypoglycaemia in England: a retrospective, observational study (2016)
Journal Article
Zaccardi, F., Davies, M. J., Dhalwani, N. N., Webb, D. R., Housley, G., Shaw, D. E., Hatton, J. W., & Khunti, K. (2016). Trends in hospital admissions for hypoglycaemia in England: a retrospective, observational study. Lancet Diabetes and Endocrinology, 4(8), 677-685. https://doi.org/10.1016/S2213-8587%2816%2930091-2

Background

Studies in the USA and Canada have reported increasing or stable rates of hospital admissions for hypoglycaemia. Some data from small studies are available for other countries. We aimed to gather information about long-term trends in ho... Read More about Trends in hospital admissions for hypoglycaemia in England: a retrospective, observational study.

NightShift simulation to train newly qualified doctors in non-technical skills: a feasibility study (2016)
Journal Article
Brown, M., Pinchin, J., Valand, R., Larkin, C., Pattinson, J., Benning, K., Housley, G., Hatton, J., Shaw, D. E., Syrysko, P., Sharples, S., & Blakey, J. (2016). NightShift simulation to train newly qualified doctors in non-technical skills: a feasibility study. Future Hospital Journal, 3(2), https://doi.org/10.7861/futurehosp.3-2-94

There is growing evidence of greater rates of morbidity and mortality in hospitals during out-of-hours shifts, which appears to be exacerbated during the period in which newly qualified doctors commence work. In order to combat this issue, an online... Read More about NightShift simulation to train newly qualified doctors in non-technical skills: a feasibility study.

Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation (2016)
Journal Article
Clifford, R. L., Jones, M. J., MacIsaac, J. L., McEwen, L. M., Goodman, S. J., Mostafavi, S., Kobor, M. S., & Carlsten, C. (2017). Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation. Journal of Allergy and Clinical Immunology, 139(1), https://doi.org/10.1016/j.jaci.2016.03.046

Background

Allergic disease affects 30% to 40% of the world's population, and its development is determined by the interplay between environmental and inherited factors. Air pollution, primarily consisting of diesel exhaust emissions, has increase... Read More about Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation.