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Outputs (327)

Targeted sequencing of lung function loci in chronic obstructive pulmonary disease cases and controls (2017)
Journal Article
Artigas, M. S., Wain, L. V., Shrine, N., McKeever, T. M., Sayers, I., Hall, I. P., & Tobin, M. D. (2017). Targeted sequencing of lung function loci in chronic obstructive pulmonary disease cases and controls. PLoS ONE, 12(1), Article e0170222. https://doi.org/10.1371/journal.pone.0170222

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide; smoking is the main risk factor for COPD, but genetic factors are also relevant contributors. Genome-wide association studies (GWAS) of the lung function meas... Read More about Targeted sequencing of lung function loci in chronic obstructive pulmonary disease cases and controls.

Evidence for large-scale gene-by-smoking interaction effects on pulmonary function (2017)
Journal Article
Aschard, H., Tobin, M. D., Hancock, D. B., Skurnik, D., Sood, A., James, A., Vernon Smith, A., Manichaikul, A. W., Campbell, A., Prins, B. P., Hayward, C., Loth, D. W., Porteous, D. J., Strachan, D. P., Zeggini, E., O’Connor, G. T., Brusselle, G. G., Boezen, H. M., Schulz, H., Deary, I. J., …Kraft, P. (in press). Evidence for large-scale gene-by-smoking interaction effects on pulmonary function. International Journal of Epidemiology, Article dyw318. https://doi.org/10.1093/ije/dyw318

Background: Smoking is the strongest environmental risk factor for reduced pulmonary function. The genetic component of various pulmonary traits has also been demonstrated, and at least 26 loci have been reproducibly associated with either FEV1 (forc... Read More about Evidence for large-scale gene-by-smoking interaction effects on pulmonary function.

Socioeconomic deprivation and the outcome of pulmonary rehabilitation in England and Wales (2017)
Journal Article
Steiner, M. C., Lowe, D., Beckford, K., Blakey, J., Bolton, C. E., Elkin, S., Man, W. D. .-C., Roberts, C. M., Sewell, L., Walker, P., & Singh, S. J. (2017). Socioeconomic deprivation and the outcome of pulmonary rehabilitation in England and Wales. Thorax, 72(6), 530-537. https://doi.org/10.1136/thoraxjnl-2016-209376

Background: Pulmonary rehabilitation (PR) improves exercise capacity and health status in patients with COPD, but many patients assessed for PR do not complete therapy. It is unknown whether socioeconomic deprivation associates with rates of completi... Read More about Socioeconomic deprivation and the outcome of pulmonary rehabilitation in England and Wales.

sTREM-1 is elevated in cystic fibrosis and correlates with proteases (2017)
Journal Article
Forrester, D., Barr, H. L., Fogarty, A., & Knox, A. (2017). sTREM-1 is elevated in cystic fibrosis and correlates with proteases. Pediatric Pulmonology, 52(4), 467-471. https://doi.org/10.1002/ppul.23650

Background: sTREM-1 (soluble triggering receptor expressed on myeloid cells-1) is a novel inflammatory marker that may be of clinical use in cystic fibrosis (CF). Dysregulation of the TREM pathway has been demonstrated in other inflammatory diseases... Read More about sTREM-1 is elevated in cystic fibrosis and correlates with proteases.

Effect of epigenetic inhibitors on lung fibroblast phenotype change in idiopathic pulmonary fibrosis (2016)
Journal Article
Pasini, A., Brand, O. J., Jenkins, G., Knox, A. J., & Pang, L. (2016). Effect of epigenetic inhibitors on lung fibroblast phenotype change in idiopathic pulmonary fibrosis. Thorax, 71(Supp3), Article A32. https://doi.org/10.1136/thoraxjnl-2016-209333.59

Introduction and objectives: Idiopathic Pulmonary Fibrosis (IFP) is a fatal interstitial lung disease with unknown aetiology. Lung myofibroblasts (activated fibrobalsts) are the major effector cells in the pathogenesis of IPF. Transforming growth fac... Read More about Effect of epigenetic inhibitors on lung fibroblast phenotype change in idiopathic pulmonary fibrosis.

MMP-1 activation contributes to airway smooth muscle growth and asthma severity (2016)
Journal Article
Naveed, S.-U.-N., Clements, D., Jackson, D. J., Philp, C., Billington, C. K., Soomro, I. N., Reynolds, C., Harrison, T. W., Johnston, S. L., Shaw, D. E., & Johnson, S. R. (2017). MMP-1 activation contributes to airway smooth muscle growth and asthma severity. American Journal of Respiratory and Critical Care Medicine, 195(8), 1000-1009. https://doi.org/10.1164/rccm.201604-0822OC

Introduction: Matrix metalloproteinase-1 and mast cells are present in the airways of people with asthma. We hypothesised that matrix metalloproteinase-1 could be activated by mast cells and increase asthma severity. Methods: Patients with stable ast... Read More about MMP-1 activation contributes to airway smooth muscle growth and asthma severity.

NMR hyperpolarization techniques of gases (2016)
Journal Article
Barskiy, D. A., Coffey, A. M., Nikolaou, P., Mikhaylov, D. M., Goodson, B. M., Branca, R. T., Lu, G. J., Shapiro, M. G., Telkki, V.-V., Zhivonitko, V. V., Koptyug, I. V., Salnikov, O. G., Kovtunov, K. V., Bukhtiyarov, V. I., Rosen, M. S., Barlow, M. J., Safavi, S., Hall, I. P., Schröder, L., & Chekmenev, E. Y. (2017). NMR hyperpolarization techniques of gases. Chemistry - A European Journal, 23(4), 725-751. https://doi.org/10.1002/chem.201603884

Nuclear spin polarization can be significantly increased through the process of hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance (NMR) experiments by 4–8 orders of magnitude. Hyperpolarized gases, unlike liqu... Read More about NMR hyperpolarization techniques of gases.

What are the pros and cons of electronically monitoring inhaler use in asthma? A multistakeholder perspective (2016)
Journal Article
Howard, S., Lang, A. R., Sharples, S., & Shaw, D. E. (in press). What are the pros and cons of electronically monitoring inhaler use in asthma? A multistakeholder perspective. BMJ Open Respiratory Research, 3(1), Article e000159. https://doi.org/10.1136/bmjresp-2016-000159

Introduction

Electronic monitoring devices (EMDs) are the optimal method for collecting objective data on inhaler use in asthma. Recent research has investigated the attitudes of patients with asthma towards these devices. However, no research to... Read More about What are the pros and cons of electronically monitoring inhaler use in asthma? A multistakeholder perspective.

S133 Investigating genome wide dna methylation in airway and parenchymal fibroblasts from healthy individuals and individuals with copd (2016)
Presentation / Conference Contribution
Clifford, R. L., Fishbane, N., Rajasekar, P., Fisher, A., Kobor, M., Knox, A., & Hackett, T. S133 Investigating genome wide dna methylation in airway and parenchymal fibroblasts from healthy individuals and individuals with copd

Rationale: Lung fibroblasts are implicated in respiratory disease pathology including chronic obstructive pulmonary disease (COPD). Phenotypic differences between fibroblasts isolated from the airway versus the parenchyma have been described but no s... Read More about S133 Investigating genome wide dna methylation in airway and parenchymal fibroblasts from healthy individuals and individuals with copd.