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Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study

Forrester, Doug L.; Knox, Alan J.; Smyth, Alan R.; Fogarty, Andrew W.

Authors

Doug L. Forrester

Alan J. Knox

Alan R. Smyth

Andrew W. Fogarty



Abstract

Background
Body habitus differences may explain some of the variation in lung function between individuals with cystic fibrosis (CF). We tested the hypothesis that measures of lean muscle mass and obesity are independently associated with lung function in CF.

Methods
Cross-sectional study design using UK CF registry data from 2096 clinically stable adults.

Results
Serum creatinine and BMI were positively and independently associated with FEV1 and FVC. One standard deviation increment in serum creatinine was associated with an FEV1 increase of 171 ml (95% confidence intervals CI: + 116 to + 227 ml) in males and 90 ml (95% CI: + 46 to + 133 ml) in females. Compared to the reference group of 20–24.9 kg/m2, those with a BMI < 20 kg/m2 had lower FEV1 with values of − 642 ml (95%CI: − 784 to − 500 ml) for males and − 468 ml (95%CI: − 564 to − 372 ml) for females.

Conclusions
Prospective studies and controlled trials are required to ascertain if these associations have therapeutic potential in modifying disease progression.

Journal Article Type Article
Publication Date May 1, 2013
Journal Journal of Cystic Fibrosis
Print ISSN 1569-1993
Electronic ISSN 1873-5010
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 12
Issue 3
APA6 Citation Forrester, D. L., Knox, A. J., Smyth, A. R., & Fogarty, A. W. (2013). Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study. Journal of Cystic Fibrosis, 12(3), doi:10.1016/j.jcf.2012.08.008
DOI https://doi.org/10.1016/j.jcf.2012.08.008
Keywords Body mass index; Lung function; Muscle; Cystic fibrosis
Publisher URL http://www.sciencedirect.com/science/article/pii/S1569199312001476
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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