Doug L. Forrester
Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study
Forrester, Doug L.; Knox, Alan J.; Smyth, Alan R.; Fogarty, Andrew W.
Alan J. Knox
Alan R. Smyth
Andrew W. Fogarty
Body habitus differences may explain some of the variation in lung function between individuals with cystic fibrosis (CF). We tested the hypothesis that measures of lean muscle mass and obesity are independently associated with lung function in CF.
Cross-sectional study design using UK CF registry data from 2096 clinically stable adults.
Serum creatinine and BMI were positively and independently associated with FEV1 and FVC. One standard deviation increment in serum creatinine was associated with an FEV1 increase of 171 ml (95% confidence intervals CI: + 116 to + 227 ml) in males and 90 ml (95% CI: + 46 to + 133 ml) in females. Compared to the reference group of 20–24.9 kg/m2, those with a BMI < 20 kg/m2 had lower FEV1 with values of − 642 ml (95%CI: − 784 to − 500 ml) for males and − 468 ml (95%CI: − 564 to − 372 ml) for females.
Prospective studies and controlled trials are required to ascertain if these associations have therapeutic potential in modifying disease progression.
Forrester, D. L., Knox, A. J., Smyth, A. R., & Fogarty, A. W. (2013). Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study. Journal of Cystic Fibrosis, 12(3), https://doi.org/10.1016/j.jcf.2012.08.008
|Journal Article Type||Article|
|Acceptance Date||Aug 10, 2012|
|Online Publication Date||Sep 5, 2012|
|Publication Date||May 1, 2013|
|Deposit Date||Mar 27, 2014|
|Publicly Available Date||Mar 27, 2014|
|Journal||Journal of Cystic Fibrosis|
|Peer Reviewed||Peer Reviewed|
|Keywords||Body mass index; Lung function; Muscle; Cystic fibrosis|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0|
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
You might also like
sTREM-1 is elevated in cystic fibrosis and correlates with proteases
The differential effects of azithromycin on the airway epithelium in vitro and in vivo