Epigenetics and miRNA emerge as key regulators of smooth muscle cell phenotype and function

Clifford, Rachel L.; Singer, Cherie A.; John, Alison E.

Abstract

Regulation of phenotypic plasticity in smooth muscle requires an understanding of the mechanisms regulating phenotype-specific genes and the processes dysregulated during pathogenesis. Decades of study in airway smooth muscle has provided extensive knowledge of the gene expression patterns and signaling pathways necessary to maintain and alter smooth muscle cell phenotype. With this solid foundation, the importance and complexity of inheritable epigenetic modifications and mechanisms silencing gene expression have now emerged as fundamental components regulating aspects of inflammation, proliferation and remodeling.

Citation

Clifford, R. L., Singer, C. A., & John, A. E. (2013). Epigenetics and miRNA emerge as key regulators of smooth muscle cell phenotype and function. Pulmonary Pharmacology and Therapeutics, 26(1), 75-85. https://doi.org/10.1016/j.pupt.2012.07.002

• Journal Article Type: Article
• Acceptance Date: Jul 4, 2012
• Online Publication Date: Jul 15, 2012
• Publication Date: 2013-02
• Deposit Date: Oct 16, 2019
• Journal: Pulmonary Pharmacology & Therapeutics
• Print ISSN: 1094-5539
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 26
• Issue: 1
• Pages: 75-85
• DOI: https://doi.org/10.1016/j.pupt.2012.07.002
• Keywords: Pharmacology (medical); Pulmonary and Respiratory Medicine; Biochemistry, medical
• Public URL: https://nottingham-repository.worktribe.com/output/2847533
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S1094553912001137