Michelle John
Target renal damage: the microvascular associations of increased aortic stiffness in patients with COPD
John, Michelle; Hussain, Samia; Prayle, Andrew; Simms, Rebecca; Cockroft, John R.; Bolton, Charlotte E.
Authors
Samia Hussain
ANDREW PRAYLE andrew.prayle@nottingham.ac.uk
Clinical Associate Professor
Rebecca Simms
John R. Cockroft
Charlotte E. Bolton
Abstract
Background
Although renal impairment has been described in COPD, there is opportunity to evaluate further to determine nature and consider optimal management. Increased aortic stiffness, as seen in COPD, leads to reduced buffering of pulsatile flow. We hypothesised that urinary albumin creatinine ratio (UACR) would reflect glomerular damage related to aortic stiffness.
Methods
Patients with COPD and controls underwent spirometry, blood pressure, arterial stiffness - aortic pulse wave velocity (PWV) and provided a spot urine sample for UACR, with other renal biomarkers measured.
Results
The UACR was increased in patients (n?=?52): 0.80 mg/mmol compared to controls (n?=?34): 0.46 mg/mmol, p?
Citation
John, M., Hussain, S., Prayle, A., Simms, R., Cockroft, J. R., & Bolton, C. E. (2013). Target renal damage: the microvascular associations of increased aortic stiffness in patients with COPD. Respiratory Research, 14(31), https://doi.org/10.1186/1465-9921-14-31
Journal Article Type | Article |
---|---|
Publication Date | Mar 1, 2013 |
Deposit Date | May 9, 2014 |
Publicly Available Date | Mar 28, 2024 |
Journal | Respiratory Research |
Print ISSN | 1465-9921 |
Electronic ISSN | 1465-9921 |
Publisher | Springer Verlag |
Peer Reviewed | Peer Reviewed |
Volume | 14 |
Issue | 31 |
DOI | https://doi.org/10.1186/1465-9921-14-31 |
Keywords | Arterial Stiffness, Biomarkers, Haemodynamics, Kidney, Renal, Microvascular |
Public URL | https://nottingham-repository.worktribe.com/output/1002621 |
Publisher URL | http://respiratory-research.com/content/14/1/31/abstract# |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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