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Target renal damage: the microvascular associations of increased aortic stiffness in patients with COPD

John, Michelle; Hussain, Samia; Prayle, Andrew; Simms, Rebecca; Cockroft, John R.; Bolton, Charlotte E.

Authors

Michelle John

Samia Hussain

Andrew Prayle

Rebecca Simms

John R. Cockroft

Charlotte E. Bolton

Abstract

Background
Although renal impairment has been described in COPD, there is opportunity to evaluate further to determine nature and consider optimal management. Increased aortic stiffness, as seen in COPD, leads to reduced buffering of pulsatile flow. We hypothesised that urinary albumin creatinine ratio (UACR) would reflect glomerular damage related to aortic stiffness.
Methods
Patients with COPD and controls underwent spirometry, blood pressure, arterial stiffness - aortic pulse wave velocity (PWV) and provided a spot urine sample for UACR, with other renal biomarkers measured.
Results
The UACR was increased in patients (n = 52): 0.80 mg/mmol compared to controls (n = 34): 0.46 mg/mmol, p 

Journal Article Type Article
Publication Date Mar 1, 2013
Journal Respiratory Research
Print ISSN 1465-9921
Electronic ISSN 1465-9921
Publisher Humana Press
Peer Reviewed Peer Reviewed
Volume 14
Issue 31
DOI https://doi.org/10.1186/1465-9921-14-31
Keywords Arterial Stiffness, Biomarkers, Haemodynamics, Kidney, Renal, Microvascular
Publisher URL http://respiratory-research.com/content/14/1/31/abstract#
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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