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Target renal damage: the microvascular associations of increased aortic stiffness in patients with COPD

John, Michelle; Hussain, Samia; Prayle, Andrew; Simms, Rebecca; Cockroft, John R.; Bolton, Charlotte E.

Authors

Michelle John

Samia Hussain

ANDREW PRAYLE andrew.prayle@nottingham.ac.uk
Clinical Associate Professor

Rebecca Simms

John R. Cockroft

Charlotte E. Bolton



Abstract

Background
Although renal impairment has been described in COPD, there is opportunity to evaluate further to determine nature and consider optimal management. Increased aortic stiffness, as seen in COPD, leads to reduced buffering of pulsatile flow. We hypothesised that urinary albumin creatinine ratio (UACR) would reflect glomerular damage related to aortic stiffness.
Methods
Patients with COPD and controls underwent spirometry, blood pressure, arterial stiffness - aortic pulse wave velocity (PWV) and provided a spot urine sample for UACR, with other renal biomarkers measured.
Results
The UACR was increased in patients (n?=?52): 0.80 mg/mmol compared to controls (n?=?34): 0.46 mg/mmol, p?

Citation

John, M., Hussain, S., Prayle, A., Simms, R., Cockroft, J. R., & Bolton, C. E. (2013). Target renal damage: the microvascular associations of increased aortic stiffness in patients with COPD. Respiratory Research, 14(31), https://doi.org/10.1186/1465-9921-14-31

Journal Article Type Article
Publication Date Mar 1, 2013
Deposit Date May 9, 2014
Publicly Available Date Mar 28, 2024
Journal Respiratory Research
Print ISSN 1465-9921
Electronic ISSN 1465-9921
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 14
Issue 31
DOI https://doi.org/10.1186/1465-9921-14-31
Keywords Arterial Stiffness, Biomarkers, Haemodynamics, Kidney, Renal, Microvascular
Public URL https://nottingham-repository.worktribe.com/output/1002621
Publisher URL http://respiratory-research.com/content/14/1/31/abstract#

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