Outputs (63)

The impact of tumour biology on the management of primary breast cancer in older women—based on a research programme in Nottingham (2021)
Journal Article

The incidence of breast cancer increases with age. Average life expectancies are increasing; the older population is expanding globally. This presents a huge challenge on an international scale in the coming years as more older people are living with... Read More about The impact of tumour biology on the management of primary breast cancer in older women—based on a research programme in Nottingham.

Molecular disruption of DNA polymerase β for platinum sensitisation and synthetic lethality in epithelial ovarian cancers (2021)
Journal Article

Targeting PARP1 [Poly(ADP-Ribose) Polymerase 1] for synthetic lethality is a new strategy for BRCA germ-line mutated or platinum sensitive ovarian cancers. However, not all patients respond due to intrinsic or acquired resistance to PARP1 inhibitor.... Read More about Molecular disruption of DNA polymerase β for platinum sensitisation and synthetic lethality in epithelial ovarian cancers.

Age-related biology of early-stage operable breast cancer and its impact on clinical outcome (2021)
Journal Article

As age advances, breast cancer (BC) tends to change its biological characteristics. This study aimed to explore the natural progression of such changes. The study included 2383 women with clinically T0-2N0-1M0 BC, managed by primary surgery and optim... Read More about Age-related biology of early-stage operable breast cancer and its impact on clinical outcome.

A new view of macula densa cell microanatomy (2021)
Journal Article

Although macula densa (MD) cells are chief regulatory cells in the nephron with unique microanatomical features, they have been difficult to study in full detail due to their inaccessibility and limitations in earlier microscopy techniques. The prese... Read More about A new view of macula densa cell microanatomy.

Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease (2021)
Journal Article

Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in the heart, providing support to the contracting myocardium and contributing to a myriad of physiological signaling processes. Despite the importance o... Read More about Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease.

The ICON Trauma Study: The Impact of the COVID-19 lockdown on Major Trauma workload in the UK (2021)
Journal Article

Background The global pandemic caused by SARS-CoV-2 has impacted population health and care delivery worldwide. As information emerges regarding the impact of “lockdown measures” and changes to clinical practice worldwide; there is no comparative in... Read More about The ICON Trauma Study: The Impact of the COVID-19 lockdown on Major Trauma workload in the UK.

Understanding cell?cell communication and signaling in the colorectal cancer microenvironment (2021)
Journal Article

Carcinomas are complex heterocellular systems containing epithelial cancer cells, stromal fibroblasts, and multiple immune cell?types. Cell?cell communication between these tumor microenvironments (TME) and cells drives cancer progression and influen... Read More about Understanding cell?cell communication and signaling in the colorectal cancer microenvironment.

Detection and Quantification of Novel C?terminal TDP?43 Fragments in ALS?TDP (2021)
Journal Article

The pathological hallmark of amyotrophic lateral sclerosis (ALS) is the presence of cytoplasmic inclusions, containing C‐terminal fragments of the protein TDP‐43. Here, we tested the hypothesis that highly sensitive mass spectrometry with parallel re... Read More about Detection and Quantification of Novel C?terminal TDP?43 Fragments in ALS?TDP.

Students’ Views Towards SARS-CoV-2 Mass Asymptomatic Testing, Social Distancing and Self-Isolation in a University Setting during the COVID-19 Pandemic: A Qualitative Study (2021)
Working Paper

We aimed to explore university students’ perceptions and experiences of SARS-CoV-2 mass asymptomatic testing, social distancing and self-isolation during the COVID-19 pandemic. This qualitative study comprised of four rapid online focus groups conduc... Read More about Students’ Views Towards SARS-CoV-2 Mass Asymptomatic Testing, Social Distancing and Self-Isolation in a University Setting during the COVID-19 Pandemic: A Qualitative Study.

Tailoring Pyro- and Orthophosphate Species to Enhance Stem Cell Adhesion to Phosphate Glasses (2021)
Journal Article