Understanding cell‐cell communication and signaling in the colorectal cancer microenvironment

Almusawi, Shaikha; Ahmed, Mehreen; Nateri, Abdolrahman S.

Abstract

Carcinomas are complex heterocellular systems containing epithelial cancer cells, stromal fibroblasts, and multiple immune cell‐types. Cell‐cell communication between these tumor microenvironments (TME) and cells drives cancer progression and influences response to existing therapies. In order to provide better treatments for patients, we must understand how various cell‐types collaborate within the TME to drive cancer and consider the multiple signals present between and within different cancer types. To investigate how tissues function, we need a model to measure both how signals are transferred between cells and how that information is processed within cells. The interplay of collaboration between different cell‐types requires cell‐cell communication. This article aims to review the current in vitro and in vivo mono‐cellular and multi‐cellular cultures models of colorectal cancer (CRC), and to explore how they can be used for single‐cell multi‐omics approaches for isolating multiple types of molecules from a single‐cell required for cell‐cell communication to distinguish cancer cells from normal cells. Integrating the existing single‐cell signaling measurements and models, and through understanding the cell identity and how different cell types communicate, will help predict drug sensitivities in tumor cells and between‐ and within‐patients responses.

Citation

Almusawi, S., Ahmed, M., & Nateri, A. S. (2021). Understanding cell‐cell communication and signaling in the colorectal cancer microenvironment. Clinical and Translational Medicine, 11(2), Article e308. https://doi.org/10.1002/ctm2.308

• Journal Article Type: Review
• Acceptance Date: Jan 19, 2021
• Online Publication Date: Feb 7, 2021
• Publication Date: 2021-02
• Deposit Date: Apr 8, 2021
• Publicly Available Date: Apr 9, 2021
• Journal: Clinical and Translational Medicine
• Electronic ISSN: 2001-1326
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 2
• Article Number: e308
• DOI: https://doi.org/10.1002/ctm2.308
• Public URL: https://nottingham-repository.worktribe.com/output/5289514
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1002/ctm2.308