Outputs (2546)

The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol (2020)
Journal Article
Hall, M. C., Fuller, A., Nomikos, P. A., Millar, B., Ogollah, R., Valdes, A., Greenhaff, P., Das Nair, R., Doherty, M., Walsh, D. A., & Abhishek, A. (2020). The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol. BMJ Open, 10(9), Article e037760

Introduction: Knee pain and osteoarthritis (OA) are a common cause of disability. The UK National Institute of Health and Care Excellence (NICE) OA guidelines recommend education, exercise and weight-loss advice (if overweight) as core interventions... Read More about The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol.

Site-Selective Modification of Peptides and Proteins via Interception of Free-Radical-Mediated Dechalcogenation (2020)
Journal Article
Griffiths, R. C., Smith, F. R., Long, J. E., Williams, H. E. L., Layfield, R., & Mitchell, N. J. (2020). Site-Selective Modification of Peptides and Proteins via Interception of Free-Radical-Mediated Dechalcogenation. Angewandte Chemie International Edition, 59(52), 23659-23667. https://doi.org/10.1002/anie.202006260

© 2020 The Authors. Published by Wiley-VCH GmbH The development of site-selective chemistry targeting the canonical amino acids enables the controlled installation of desired functionalities into native peptides and proteins. Such techniques facilita... Read More about Site-Selective Modification of Peptides and Proteins via Interception of Free-Radical-Mediated Dechalcogenation.

Multiple pathways of type 1 interferon production in lupus: the case for amlexanox (2020)
Journal Article
Todd, I., Thomas, R., Watt, B., Sutherland, L., Afriyie-Asante, A., Deb, B., Joseph, B., Tighe, P. J., Lanyon, P., & Fairclough, L. C. (2020). Multiple pathways of type 1 interferon production in lupus: the case for amlexanox. Rheumatology, 59(12), 3980-3982. https://doi.org/10.1093/rheumatology/keaa469

Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization (2020)
Journal Article
Pierce, B. G., Keck, Z. Y., Wang, R., Lau, P., Garagusi, K., Elkholy, K., Toth, E. A., Urbanowicz, R. A., Guest, J. D., Agnihotri, P., Kerzic, M. C., Marin, A., Andrianov, A. K., Ball, J. K., Mariuzza, R. A., Fuerst, T. R., & Foung, S. K. (2020). Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization. Journal of Virology, 94(22), https://doi.org/10.1128/JVI.00704-20

Copyright © 2020 American Society for Microbiology. An effective vaccine for hepatitis C virus (HCV) is a major unmet need, and it requires an antigen that elicits immune responses to key conserved epitopes. Based on structures of antibodies targetin... Read More about Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization.

Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties (2020)
Journal Article
Alobaid, M. A., Richards, S.-J., Alexander, M. R., Gibson, M. I., & Ghaemmaghami, A. M. (2020). Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties. Materials Today Bio, 8, Article 100080. https://doi.org/10.1016/j.mtbio.2020.100080

© 2020 The Authors New strategies for immune modulation have shown real promise in regenerative medicine as well as the fight against autoimmune diseases, allergies, and cancer. Dendritic cells (DCs) are gatekeepers of the immune system and their abi... Read More about Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties.

Cyclo(RGDfK) Functionalized Spider Silk Cell Scaffolds: Significantly Improved Performance in Just One Click (2020)
Journal Article
Harvey, D., Bray, G., Zamberlan, F., Amer, M., Goodacre, S. L., & Thomas, N. R. (2020). Cyclo(RGDfK) Functionalized Spider Silk Cell Scaffolds: Significantly Improved Performance in Just One Click. Macromolecular Bioscience, https://doi.org/10.1002/mabi.202000255

Recombinant spider silk has the potential to provide a new generation of biomaterial scaffolds as a result of its degree of biocompatibility and lack of immunogenicity. These recombinant biomaterials are, however, reported to exhibit poor cellular ad... Read More about Cyclo(RGDfK) Functionalized Spider Silk Cell Scaffolds: Significantly Improved Performance in Just One Click.

The effect of agri-environment schemes on bees on Shropshire farms (2020)
Journal Article
Crowther, L. I., & Gilbert, F. (2020). The effect of agri-environment schemes on bees on Shropshire farms. Journal for Nature Conservation, 58, Article 125895. https://doi.org/10.1016/j.jnc.2020.125895

© 2020 The decline of bees and other invertebrate pollinators is cause for global concern, with modern intensive agriculture identified as a key driver. Government-run agri-environment schemes (AES) have the potential to restore the local landscape t... Read More about The effect of agri-environment schemes on bees on Shropshire farms.

Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR (2020)
Journal Article
Grossman, S., Soukarieh, F., Richardson, W., Liu, R., Mashabi, A., Emsley, J., Williams, P., Cámara, M., & Stocks, M. J. (2020). Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR. European Journal of Medicinal Chemistry, 208, Article 112778. https://doi.org/10.1016/j.ejmech.2020.112778

© 2020 The Authors Rising numbers of cases of multidrug- and extensively drug-resistant Pseudomonas aeruginosa over recent years have created an urgent need for novel therapeutic approaches to cure potentially fatal infections. One such approach is v... Read More about Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR.

12-Month changes of muscle strength, body composition and physical activity in adults with dystrophinopathies (2020)
Journal Article
Jacques, M. F., Onambele-Pearson, G. L., Reeves, N. D., Stebbings, G. K., Dawson, E. A., Stockley, R. C., Edwards, B., & Morse, C. I. (2022). 12-Month changes of muscle strength, body composition and physical activity in adults with dystrophinopathies. Disability and Rehabilitation, 44(10), 1847-1854. https://doi.org/10.1080/09638288.2020.1808087

Purpose
Muscular dystrophy (MD) is an umbrella term for muscle wasting conditions, for which longitudinal changes in function and body composition are well established in children with Duchenne (DMD), however, changes in adults with DMD and Beckers... Read More about 12-Month changes of muscle strength, body composition and physical activity in adults with dystrophinopathies.

Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients (2020)
Journal Article
Funnell, S. G., Dowling, W. E., Muñoz-Fontela, C., Gsell, P. S., Ingber, D. E., Hamilton, G. A., Delang, L., Rocha-Pereira, J., Kaptein, S., Dallmeier, K. H., Neyts, J., Rosenke, K., de Wit, E., Feldmann, H., Maisonnasse, P., Le Grand, R., Frieman, M. B., & Coleman, C. M. (2020). Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients. Nature Communications, 11(1), Article 4253. https://doi.org/10.1038/s41467-020-17907-w