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12-Month changes of muscle strength, body composition and physical activity in adults with dystrophinopathies

Jacques, Matthew F.; Onambele-Pearson, Gladys L.; Reeves, Neil D.; Stebbings, Georgina K.; Dawson, Ellen A.; Stockley, Rachel C.; Edwards, Bryn; Morse, Christopher I.


Gladys L. Onambele-Pearson

Neil D. Reeves

Georgina K. Stebbings

Ellen A. Dawson

Rachel C. Stockley

Bryn Edwards

Christopher I. Morse


Muscular dystrophy (MD) is an umbrella term for muscle wasting conditions, for which longitudinal changes in function and body composition are well established in children with Duchenne (DMD), however, changes in adults with DMD and Beckers (BMD), respectively, remain poorly reported. This study aims to assess 12-month changes in lower-limb strength, muscle size, body composition and physical activity in adults with Muscular Dystrophy (MD).

Adult males with Duchenne MD (DMD; N = 15) and Beckers MD (BMD; N = 12) were assessed at baseline and 12-months for body composition (Body fat and lean body mass (LBM)), Isometric maximal voluntary contraction (Knee-Extension (KEMVC) and Plantar-Flexion (PFMVC)) and physical activity (tri-axial accelerometry).

12-Month change in strength was found as −19% (PFMVC) and −14% (KEMVC) in DMD. 12-Month change in strength in BMD, although non-significant, was explained by physical activity (R2=0.532–0.585). Changes in LBM (DMD) and body fat (BMD) were both masked by non-significant changes in body mass.

Journal Article Type Article
Acceptance Date Aug 6, 2020
Online Publication Date Aug 27, 2020
Publication Date May 8, 2022
Deposit Date Nov 26, 2022
Journal Disability and Rehabilitation
Print ISSN 0963-8288
Electronic ISSN 1464-5165
Publisher Taylor and Francis
Peer Reviewed Peer Reviewed
Volume 44
Issue 10
Pages 1847-1854
Keywords Rehabilitation
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