MATTHEW JACQUES Matthew.Jacques@nottingham.ac.uk
Assistant Professor
MATTHEW JACQUES Matthew.Jacques@nottingham.ac.uk
Assistant Professor
Gladys L. Onambele-Pearson
Neil D. Reeves
Georgina K. Stebbings
Ellen A. Dawson
Rachel C. Stockley
Bryn Edwards
Christopher I. Morse
Purpose
Muscular dystrophy (MD) is an umbrella term for muscle wasting conditions, for which longitudinal changes in function and body composition are well established in children with Duchenne (DMD), however, changes in adults with DMD and Beckers (BMD), respectively, remain poorly reported. This study aims to assess 12-month changes in lower-limb strength, muscle size, body composition and physical activity in adults with Muscular Dystrophy (MD).
Methods
Adult males with Duchenne MD (DMD; N = 15) and Beckers MD (BMD; N = 12) were assessed at baseline and 12-months for body composition (Body fat and lean body mass (LBM)), Isometric maximal voluntary contraction (Knee-Extension (KEMVC) and Plantar-Flexion (PFMVC)) and physical activity (tri-axial accelerometry).
Results
12-Month change in strength was found as −19% (PFMVC) and −14% (KEMVC) in DMD. 12-Month change in strength in BMD, although non-significant, was explained by physical activity (R2=0.532–0.585). Changes in LBM (DMD) and body fat (BMD) were both masked by non-significant changes in body mass.
Jacques, M. F., Onambele-Pearson, G. L., Reeves, N. D., Stebbings, G. K., Dawson, E. A., Stockley, R. C., …Morse, C. I. (2022). 12-Month changes of muscle strength, body composition and physical activity in adults with dystrophinopathies. Disability and Rehabilitation, 44(10), 1847-1854. https://doi.org/10.1080/09638288.2020.1808087
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 6, 2020 |
Online Publication Date | Aug 27, 2020 |
Publication Date | May 8, 2022 |
Deposit Date | Nov 26, 2022 |
Journal | Disability and Rehabilitation |
Print ISSN | 0963-8288 |
Electronic ISSN | 1464-5165 |
Publisher | Taylor and Francis |
Peer Reviewed | Peer Reviewed |
Volume | 44 |
Issue | 10 |
Pages | 1847-1854 |
DOI | https://doi.org/10.1080/09638288.2020.1808087 |
Keywords | Rehabilitation |
Public URL | https://nottingham-repository.worktribe.com/output/14040832 |
Publisher URL | https://www.tandfonline.com/doi/full/10.1080/09638288.2020.1808087 |
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