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Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice (2025)
Journal Article
Chrisp, R., Masterson, M., Pope, R., Roberts, C. J., Collins, H. M., Watson, D. J. G., O’Neil, D., Aagaard, K. M., Gibson, C. L., Heery, D. M., & Moran, P. M. (2025). Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice. Scientific Reports, 15(1), Article 8347. https://doi.org/10.1038/s41598-025-92938-1

NPAS2 (Neuronal PAS Domain Protein 2) is a component of the core circadian clock and the coordinated activity between central brain and peripheral liver clock proteins postulated to be instrumental for linking behaviour and metabolism. We investigate... Read More about Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice.

Programming of pluripotency and the germline co-evolved from a Nanog ancestor (2025)
Journal Article
Crowley, D., Simpson, L., Chatfield, J., Forey, T., Allegrucci, C., Sang, F., Holmes, N., Genikhovich, G., Technau, U., Cunningham, D., Silva, E., Mullin, N., Dixon, J. E., Loose, M., Alberio, R., & Johnson, A. D. (2025). Programming of pluripotency and the germline co-evolved from a Nanog ancestor. Cell Reports, 44(3), Article 115396. https://doi.org/10.1016/j.celrep.2025.115396

Francois Jacob proposed that evolutionary novelty arises through incremental tinkering with pre-existing genetic mechanisms. Vertebrate evolution was predicated on pluripotency—the ability of embryonic cells to form somatic germ-layers and primordial... Read More about Programming of pluripotency and the germline co-evolved from a Nanog ancestor.

Wearable devices for exercise prescription and physical activity monitoring in patients with various cardiovascular conditions (2025)
Journal Article
Terada, T., Hausen, M., Way, K. L., O’Neill, C. D., Marçal, I. R., Dorian, P., & Reed, J. L. (2025). Wearable devices for exercise prescription and physical activity monitoring in patients with various cardiovascular conditions. CJC Open, https://doi.org/10.1016/j.cjco.2025.02.017

As wearable technologies have become increasingly affordable, accessible, and practical, an increasing number of people with cardiovascular disease (CVD) are beginning to use consumer-grade devices. Common health and wellness metrics reported by wear... Read More about Wearable devices for exercise prescription and physical activity monitoring in patients with various cardiovascular conditions.

Secreted factors of Aspergillus fumigatus cause lung epithelial barrier disruption: A study using an air–liquid interface cell culture model (2025)
Journal Article
Barros, B. C. S. C., Barros, D. T. L., Brock, M., Toledo, M. S., Serrano, S. M. T., Suzuki, E., & Ghaemmaghami, A. M. (2025). Secreted factors of Aspergillus fumigatus cause lung epithelial barrier disruption: A study using an air–liquid interface cell culture model. Medical Mycology, 63(3), Article myaf018. https://doi.org/10.1093/mmy/myaf018

The effects of Aspergillus fumigatus-conditioned medium (AFCM) on the integrity of the Calu-3 cell lung epithelial barrier were investigated. AFCM led to a decrease in transepithelial electrical resistance and the disruption of the occludin network i... Read More about Secreted factors of Aspergillus fumigatus cause lung epithelial barrier disruption: A study using an air–liquid interface cell culture model.

High fat diet induces differential age- and gender-dependent changes in neuronal function in Drosophila linked to redox stress (2025)
Journal Article
de Lange, M., Yarosh, V., Farell, K., McDonnell, C., Patil, R., Hawthorn, I., Jung, M.-M., Wenje, S., & Steinert, J. R. (2025). High fat diet induces differential age- and gender-dependent changes in neuronal function in Drosophila linked to redox stress. Behavioural Brain Research, 484, Article 115510. https://doi.org/10.1016/j.bbr.2025.115510

The prevalence of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, is steadily increasing, thus posing significant challenges to global healthcare systems. Emerging evidence suggests that dietary habits, particularly consumpti... Read More about High fat diet induces differential age- and gender-dependent changes in neuronal function in Drosophila linked to redox stress.

A rapid genome-proteome approach to identify rate-limiting steps in the butyrate production pathway in probiotic Clostridium butyricum, CBM588 (2025)
Journal Article
Wood, L., Omorotionmwan, B. B., Blanchard, A. M., Dowle, A., Tooth, D., Bailey, T. S., & Griffin, R. (2025). A rapid genome-proteome approach to identify rate-limiting steps in the butyrate production pathway in probiotic Clostridium butyricum, CBM588. Anaerobe, 92, Article 102940. https://doi.org/10.1016/j.anaerobe.2025.102940

Objectives: Clostridium butyricum ferments non-digested dietary fibre in the colon to produce butyric acid. Butyrate is a four-carbon, short-chain fatty acid (SCFA) which has multiple health benefits. Many microbial products of pharmaceutical or indu... Read More about A rapid genome-proteome approach to identify rate-limiting steps in the butyrate production pathway in probiotic Clostridium butyricum, CBM588.

The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution (2025)
Journal Article
Pan, J. M., Betts, H., Cubbon, A., Bolt, E. L., Soultanas, P., & He, L. (2025). The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution. Open Biology, 15(2), https://doi.org/10.1098/rsob.240112

The human HELQ helicase is a superfamily 2, 3’-5’ helicase homologous to POLQ and RNA helicases of the Ski2-like subfamily. It is involved in diverse aspects of DNA repair and is an emerging prognosis biomarker and novel drug-target for cancer therap... Read More about The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution.