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Nitric oxide-mediated neuroinflammatory pathways as treatment targets in neurodegeneration (2025)
Book Chapter
Cale, J., Farr, T. D., Serres, S., & Steinert, J. R. (2025). Nitric oxide-mediated neuroinflammatory pathways as treatment targets in neurodegeneration. In Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disorders (79-96). Elsevier. https://doi.org/10.1016/b978-0-443-22354-9.00005-x

Vascular insufficiency associated with a dysfunctional neurovascular unit (NVU) develops over years without obvious clinical symptoms and can be exacerbated by environmental stress or lifestyle choices. Astrocytic responses to endothelial malfunction... Read More about Nitric oxide-mediated neuroinflammatory pathways as treatment targets in neurodegeneration.

KIF2C condensation concentrates PLK1 and phosphorylated BRCA2 on kinetochore microtubules in mitosis (2025)
Journal Article
Skobelkina, A., Julien, M., Jeannin, S., Miron, S., Egger, T., Chaaban, R., Bouvignies, G., Alghoul, E., Ghouil, R., Friel, C., Busso, D., Cañas, J., Theillet, F.-X., Le Bars, R., Carreira, A., Constantinou, A., Basbous, J., & Zinn-Justin, S. (2025). KIF2C condensation concentrates PLK1 and phosphorylated BRCA2 on kinetochore microtubules in mitosis. Nucleic Acids Research, 53(11), Article gkaf476. https://doi.org/10.1093/nar/gkaf476

During mitosis, the microtubule depolymerase KIF2C, the tumor suppressor BRCA2, and the kinase PLK1 contribute to the control of kinetochore-microtubule attachments. Both KIF2C and BRCA2 are phosphorylated by PLK1, and BRCA2 phosphorylated at T207 (B... Read More about KIF2C condensation concentrates PLK1 and phosphorylated BRCA2 on kinetochore microtubules in mitosis.

Wisteria floribunda agglutinin enhances Zaire ebolavirus entry through interactions at specific N-linked glycosylation sites on the virus glycoprotein complex (2025)
Journal Article
Duncan, J., Pathak, M., King, B., Bamber, H., Radford, P., Dey, J., Richardson, C., Astbury, S., McClure, P., Ball, J. K., Urbanowicz, R. A., & Tarr, A. (2025). Wisteria floribunda agglutinin enhances Zaire ebolavirus entry through interactions at specific N-linked glycosylation sites on the virus glycoprotein complex. Journal of General Virology, 106(6), Article 002120. https://doi.org/10.1099/jgv.0.002120

Entry of Zaire ebolavirus (EBOV) into a host cell is a complex process requiring interactions between the viral glycoproteins (GPs) and cellular factors. These entry factors are cell-specific and can include cell surface lectins and phosphatidylserin... Read More about Wisteria floribunda agglutinin enhances Zaire ebolavirus entry through interactions at specific N-linked glycosylation sites on the virus glycoprotein complex.

Assessing CometChip technology for DNA damage studies in non-model species: distinct UV-induced responses in turtles and mammals (2025)
Journal Article
Bulls, S. E., Finn, E., Sykora, P., Lynch, V. J., Pramanik, P., Glaberman, S., & Chiari, Y. (2025). Assessing CometChip technology for DNA damage studies in non-model species: distinct UV-induced responses in turtles and mammals. BMC Research Notes, 18(1), Article 243. https://doi.org/10.1186/s13104-025-07285-1

Objective: We evaluated the feasibility of using the high-throughput CometChip to assess DNA damage in non-model species. Specifically, we measured UVA-induced damage in fibroblasts from five turtle and four mammalian species with diverse life histor... Read More about Assessing CometChip technology for DNA damage studies in non-model species: distinct UV-induced responses in turtles and mammals.

Come rain or shine: effects of external conditions on the properties of linyphiid silk (2025)
Journal Article
Wharton, D., Weston, N., & Goodacre, S. (2025). Come rain or shine: effects of external conditions on the properties of linyphiid silk. Frontiers in Arachnid Science, 4, Article 1580992. https://doi.org/10.3389/frchs.2025.1580992

Spiders have adapted to a wide range of ecological niches, accompanied by the diversification of their silk, which performs various ecological functions under different environmental conditions. This study investigates the physical properties of silk... Read More about Come rain or shine: effects of external conditions on the properties of linyphiid silk.

Prolonged nicotine exposure, via electronic cigarette, selectively increases Bdnf/TrkB transcription, dynorphin peptide levels and OLIG2 in male rat VTA (2025)
Journal Article
Rullo, L., Morosini, C., Losapio, L. M., Vivarelli, F., Paolini, M., Fairclough, L. C., Canistro, D., Romualdi, P., & Candeletti, S. (2025). Prolonged nicotine exposure, via electronic cigarette, selectively increases Bdnf/TrkB transcription, dynorphin peptide levels and OLIG2 in male rat VTA. Neuropharmacology, 278, Article 110540. https://doi.org/10.1016/j.neuropharm.2025.110540

Different drugs of abuse affect the Central Nervous System (CNS) neuronal networks and reshape the expression of neuroplasticity-related genes in crucial parts of the mesocorticolimbic reward circuitry, such as the ventral tegmental area (VTA) and th... Read More about Prolonged nicotine exposure, via electronic cigarette, selectively increases Bdnf/TrkB transcription, dynorphin peptide levels and OLIG2 in male rat VTA.

The maturation of spinal dorsal horn nociceptive neuronal network activity over the postnatal period (2025)
Journal Article
Battell, E., Smith, N., Woodhams, S., Rich, L., Donaldson, L., Brown, A., Greenspon, C., Chapman, V., & Hathway, G. (in press). The maturation of spinal dorsal horn nociceptive neuronal network activity over the postnatal period. PAIN Reports,

Objective:

The dorsal horn (DH) of the spinal cord is physiologically immature at birth. Spinal excitability increases and wide dynamic range (WDR) neurons in lamina V have lowered activation thresholds and larger receptive field sizes. The DH is... Read More about The maturation of spinal dorsal horn nociceptive neuronal network activity over the postnatal period.

Fusarium-based mycoprotein: Advancements in the production of sustainable meat substitutes (2025)
Journal Article
Gnaim, R., Dyer, P. S., & Ledesma-Amaro, R. (2025). Fusarium-based mycoprotein: Advancements in the production of sustainable meat substitutes. Trends in Food Science and Technology, 159, Article 104981. https://doi.org/10.1016/j.tifs.2025.104981

Background:

Pursuing sustainable and nutritious food has positioned Fusarium-based mycoprotein as a promising solution to the environmental and health challenges posed by some traditional agricultural practices and types of food. As consumer awar... Read More about Fusarium-based mycoprotein: Advancements in the production of sustainable meat substitutes.

ROBIN: A unified nanopore-based assay integrating intraoperative methylome classification and next-day comprehensive profiling for ultra-rapid tumor diagnosis (2025)
Journal Article
Deacon, S., Cahyani, I., Holmes, N., Fox, G., Munro, R., Wibowo, S., Murray, T., Mason, H., Housley, M., Martin, D., Sharif, A., Patel, A., Goldspring, R., Brandner, S., Sahm, F., Smith, S., Paine, S., & Loose, M. (2025). ROBIN: A unified nanopore-based assay integrating intraoperative methylome classification and next-day comprehensive profiling for ultra-rapid tumor diagnosis. Neuro-Oncology, https://doi.org/10.1093/neuonc/noaf103

Background
Advances in our technological capacity to interrogate CNS tumor biology have led to the ever increasing use of genomic sequencing in diagnostic decision making. Presently, CNS tumors are classified based on their epigenetic signatures, le... Read More about ROBIN: A unified nanopore-based assay integrating intraoperative methylome classification and next-day comprehensive profiling for ultra-rapid tumor diagnosis.