Lessons from the PROTECT-CH COVID-19 platform trial in care homes
(2024)
Journal Article
Bath, P. M., Ball, J., Boyd, M., Gage, H., Glover, M., Godfrey, M., Guthrie, B., Hewitt, J., Howard, R., Jaki, T., Juszczak, E., Lasserson, D., Leighton, P., Leyland, V., Shen Lim, W., Logan, P., Meakin, G., Montgomery, A., Ogollah, R., Passmore, P., …Gordon, A. L. (in press). Lessons from the PROTECT-CH COVID-19 platform trial in care homes. Health Technology Assessment,
Outputs (2439)
In-utero exposure to real-life environmental chemicals disrupts gene expression within the hypothalamo-pituitary-gonadal axis of prepubertal and adult rams (2024)
Journal Article
Ghasemzadeh Hasankolaei, M., Evans, N. P., Elcombe, C. S., Lea, R. G., Sinclair, K. D., Padmanabhan, V., & Bellingham, M. (2025). In-utero exposure to real-life environmental chemicals disrupts gene expression within the hypothalamo-pituitary-gonadal axis of prepubertal and adult rams. Environmental Research, 264, Article 120303. https://doi.org/10.1016/j.envres.2024.120303Environmental chemicals (ECs) have been associated with a broad range of disorders and diseases. Daily exposure to various ECs in the environment, or real-life exposure, has raised significant public health concerns. Utilizing the biosolids-treated p... Read More about In-utero exposure to real-life environmental chemicals disrupts gene expression within the hypothalamo-pituitary-gonadal axis of prepubertal and adult rams.
Global co-regulatory cross talk between m6A and m5C RNA methylation systems coordinate cellular responses and brain disease pathways (2024)
Journal Article
Orji, O. C., Stones, J., Rajani, S., Markus, R., Demirbugen Öz, M., & Knight, H. M. (2024). Global co-regulatory cross talk between m6A and m5C RNA methylation systems coordinate cellular responses and brain disease pathways. Molecular Neurobiology, https://doi.org/10.1007/s12035-024-04555-0N6 adenosine and C5 cytosine modification of mRNAs, tRNAs and rRNAs are regulated by the behaviour of distinct sets of writer, reader and eraser effector proteins which are conventionally considered to function independently. Here, we provide evidenc... Read More about Global co-regulatory cross talk between m6A and m5C RNA methylation systems coordinate cellular responses and brain disease pathways.
Practicality, Validity, and Responsiveness of Using the Proxy Version of the Child Health Utility–9 Dimensions With Children Aged 2 to 5 Years (2024)
Journal Article
Sach, T. H., Williams, H. C., Allen, H., Boyle, R., Kelleher, M., Brown, S., Cork, M., Flohr, C., Jay, N., Lartey, S., Davies, C., Lawton, S., Perkin, M., Ridd, M., Brooks, J., Tarr, S., Wyatt, L., & Thomas, K. (2024). Practicality, Validity, and Responsiveness of Using the Proxy Version of the Child Health Utility–9 Dimensions With Children Aged 2 to 5 Years. Value in Health, https://doi.org/10.1016/j.jval.2024.08.010
Objectives
To assess the practicality, validity and responsiveness of proxy CHU-9D in children aged 2-5 years.
Methods
We used data from BEEP, a UK randomised co... Read More about Practicality, Validity, and Responsiveness of Using the Proxy Version of the Child Health Utility–9 Dimensions With Children Aged 2 to 5 Years.
Exploiting phenotypic heterogeneity to improve production of glutathione by yeast (2024)
Journal Article
Xu, M., Vallières, C., Finnis, C., Winzer, K., & Avery, S. V. (2024). Exploiting phenotypic heterogeneity to improve production of glutathione by yeast. Microbial Cell Factories, 23(1), Article 267. https://doi.org/10.1186/s12934-024-02536-5Background: Gene expression noise (variation in gene expression among individual cells of a genetically uniform cell population) can result in heterogenous metabolite production by industrial microorganisms, with cultures containing both low- and hig... Read More about Exploiting phenotypic heterogeneity to improve production of glutathione by yeast.
A Hybrid Rehabilitation Program for Adults with Peripheral Artery Disease (HY-PAD): A Pre-Post Intervention Study to Assess Its Feasibility (2024)
Journal Article
Terada, T., Hausen, M., Mir, H., Reed, J. L., & Coutinho, T. D. (2025). A Hybrid Rehabilitation Program for Adults with Peripheral Artery Disease (HY-PAD): A Pre-Post Intervention Study to Assess Its Feasibility. CJC Open, 7(1), 110-119. https://doi.org/10.1016/j.cjco.2024.09.017Background
Supervised exercise programs improve walking impairment and quality of life (QoL) in patients with peripheral artery disease (PAD). However, such programs are underutilized, due to their limited accessibility. A feasible and effective exe... Read More about A Hybrid Rehabilitation Program for Adults with Peripheral Artery Disease (HY-PAD): A Pre-Post Intervention Study to Assess Its Feasibility.
International review of blood donation screening for anti‐HBc and occult hepatitis B virus infection (2024)
Journal Article
Fu, M. X., Faddy, H. M., Candotti, D., Groves, J., Saa, P., Styles, C., Adesina, O., Perez Carrillo, J., Seltsam, A., Weber‐Schehl, M., O'Brien, S. F., Drews, S. J., Benyin Aidoo, N., Pajares, Á. L., Navarro Perez, L., Deng, X., van de Laar, T., Laperche, S., Lehtisalo, R., Yilmaz, S., …on behalf of the Virology subgroup of the ISBT WP-TTID. (2024). International review of blood donation screening for anti‐HBc and occult hepatitis B virus infection. Transfusion, 64(11), 2144-2156. https://doi.org/10.1111/trf.18018Background
Hepatitis B core antibody (anti-HBc) screening has been implemented in many blood establishments to help prevent transmission of hepatitis B virus (HBV), including from donors with occult HBV infection (OBI). We review HBV screening algor... Read More about International review of blood donation screening for anti‐HBc and occult hepatitis B virus infection.
The expanding role of cap-adjacent modifications in animals (2024)
Journal Article
Bellows, E., Fray, R. G., Knight, H. M., & Archer, N. (2024). The expanding role of cap-adjacent modifications in animals. Frontiers in RNA Research, 2, Article 1485307. https://doi.org/10.3389/frnar.2024.1485307Eukaryotic mRNA cap structures directly influence mRNA stability, translation, and immune recognition. While the significance of the mRNA cap itself has been well-established, recent research has revealed the intricate modifications to the nucleotide... Read More about The expanding role of cap-adjacent modifications in animals.
Local cryptic diversity in salinity adaptation mechanisms in the wild outcrossing Brassica fruticulosa (2024)
Journal Article
Busoms, S., da Silva, A. C., Escolà, G., Abdilzadeh, R., Curran, E., Bollmann-Giolai, A., Bray, S., Wilson, M., Poschenrieder, C., & Yant, L. (2024). Local cryptic diversity in salinity adaptation mechanisms in the wild outcrossing Brassica fruticulosa. Proceedings of the National Academy of Sciences, 121(40), Article e2407821121. https://doi.org/10.1073/pnas.2407821121It is normally supposed that populations of the same species should evolve shared mechanisms of adaptation to common stressors due to evolutionary constraint. Here, we describe a system of within-species local adaptation to coastal habitats, Brassica... Read More about Local cryptic diversity in salinity adaptation mechanisms in the wild outcrossing Brassica fruticulosa.
Discovery and Computational Modelling of Adsorbent Polymers that Effectively Immobilize SARS-CoV-2 with Potential Practical Applications (2024)
Journal Article
Xue, X., Duncan, J. D., Coleman, C. M., Contreas, L., Blackburn, C., Vivero-Lopez, M., Williams, P. M., Ball, J. K., Alexander, C., & Alexander, M. R. (2024). Discovery and Computational Modelling of Adsorbent Polymers that Effectively Immobilize SARS-CoV-2 with Potential Practical Applications. Cell Reports Physical Science, 5(9), Article 102204. https://doi.org/10.1016/j.xcrp.2024.102204Viral translocation is considered a common way for respiratory viruses to spread and contaminate the surrounding environment. Thus, the discovery of non-eluting polymers that immobilize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upo... Read More about Discovery and Computational Modelling of Adsorbent Polymers that Effectively Immobilize SARS-CoV-2 with Potential Practical Applications.