Outputs (2650)

A new species of the genus Anamylopsora (Baeomycetaceae; Ascomycota) from Deosai National Park, Gilgit-Baltistan, Pakistan (2023)
Journal Article
Usman, M., Firdous, Q., Dyer, P. S., & Khalid, A. N. (2023). A new species of the genus Anamylopsora (Baeomycetaceae; Ascomycota) from Deosai National Park, Gilgit-Baltistan, Pakistan. Lichenologist, https://doi.org/10.1017/s002428292300018x

A novel lichen species occurring on rocks was collected from three different localities within Deosai National Park, Gilgit-Baltistan, Pakistan. Phylogenetic analyses of the nrDNA ITS and nuLSU regions revealed that it clustered within the genus Anam... Read More about A new species of the genus Anamylopsora (Baeomycetaceae; Ascomycota) from Deosai National Park, Gilgit-Baltistan, Pakistan.

Cellular Responses and Targets in Food Spoilage Yeasts Exposed to Antifungal Prenylated Isoflavonoids (2023)
Journal Article
Kalli, S., Vallieres, C., Violet, J., Sanders, J.-W., Chapman, J., Vincken, J.-P., Avery, S. V., & Araya-Cloutier, C. (2023). Cellular Responses and Targets in Food Spoilage Yeasts Exposed to Antifungal Prenylated Isoflavonoids. Microbiology Spectrum, 11(4), Article e0132723. https://doi.org/10.1128/spectrum.01327-23

Prenylated isoflavonoids are phytochemicals with promising antifungal properties. Recently, it was shown that glabridin and wighteone disrupted the plasma membrane (PM) of the food spoilage yeast Zygosaccharomyces parabailii in distinct ways, which l... Read More about Cellular Responses and Targets in Food Spoilage Yeasts Exposed to Antifungal Prenylated Isoflavonoids.

Associations of obesity phenotypes with weight change, cardiometabolic benefits, and type 2 diabetes incidence during a lifestyle intervention: results from the PREVIEW study (2023)
Journal Article
Zhu, R., Huttunen-Lenz, M., Stratton, G., Handjieva-Darlenska, T., Handjiev, S., Sundvall, J., Silvestre, M. P., Jalo, E., Pietiläinen, K. H., Adam, T. C., Drummen, M., Simpson, E. J., Taylor, M. A., Poppitt, S. D., Navas-Carretero, S., Martinez, J. A., Schlicht, W., Fogelholm, M., Brand-Miller, J., & Raben, A. (2023). Associations of obesity phenotypes with weight change, cardiometabolic benefits, and type 2 diabetes incidence during a lifestyle intervention: results from the PREVIEW study. International Journal of Obesity, 47(9), 833–840. https://doi.org/10.1038/s41366-023-01328-y

Background/Objectives
Some individuals with overweight/obesity may be relatively metabolically healthy (MHO) and have a lower risk of cardiovascular disease than those with metabolically unhealthy overweight/obesity (MUO). We aimed to compare change... Read More about Associations of obesity phenotypes with weight change, cardiometabolic benefits, and type 2 diabetes incidence during a lifestyle intervention: results from the PREVIEW study.

Archaeal Hel308 suppresses recombination through a catalytic switch that controls DNA annealing (2023)
Journal Article
Lever, R., Simmons, E., Gamble-Milner, R., Buckley, R., Harrison, C., Parkes, A., Mitchell, L., Gausden, J., Škulj, S., Bertoša, B., Bolt, E. L., & Allers, T. (2023). Archaeal Hel308 suppresses recombination through a catalytic switch that controls DNA annealing. Nucleic Acids Research, 51(16), 8563-8574. https://doi.org/10.1093/nar/gkad572

Hel308 helicases promote genome stability in archaea and are conserved in metazoans, where they are known as HELQ. Their helicase mechanism is well characterised, but it is unclear how they specifically contribute to genome stability in archaea. We s... Read More about Archaeal Hel308 suppresses recombination through a catalytic switch that controls DNA annealing.

Platform Reagents Enable Synthesis of Ligand-Directed Covalent Probes: Study of Cannabinoid Receptor 2 in Live Cells (2023)
Journal Article
Kosar, M., Sykes, D. A., Viray, A. E. G., Vitale, R. M., Sarott, R. C., Ganzoni, R. L., Onion, D., Tobias, J. M., Leippe, P., Ullmer, C., Zirwes, E. A., Guba, W., Grether, U., Frank, J. A., Veprintsev, D. B., & Carreira, E. M. (2023). Platform Reagents Enable Synthesis of Ligand-Directed Covalent Probes: Study of Cannabinoid Receptor 2 in Live Cells. Journal of the American Chemical Society, 145(28), 15094–15108. https://doi.org/10.1021/jacs.2c13629

Pharmacological modulation of cannabinoid receptor type 2 (CB2R) holds promise for the treatment of neuroinflammatory disorders, such as Alzheimer’s disease. Despite the importance of CB2R, its expression and downstream signaling are insufficiently u... Read More about Platform Reagents Enable Synthesis of Ligand-Directed Covalent Probes: Study of Cannabinoid Receptor 2 in Live Cells.

Characterisation of tyrosine kinase inhibitor-receptor interactions at VEGFR2 using sunitinib-red and nanoBRET (2023)
Journal Article
Van Daele, M., Kilpatrick, L. E., Woolard, J., & Hill, S. J. (2023). Characterisation of tyrosine kinase inhibitor-receptor interactions at VEGFR2 using sunitinib-red and nanoBRET. Biochemical Pharmacology, 214, Article 115672. https://doi.org/10.1016/j.bcp.2023.115672

Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis, proliferation and migration of vascular endothelial cells. It is well known that cardiovascular safety liability for a wide range of small molecule tyrosine kinase in... Read More about Characterisation of tyrosine kinase inhibitor-receptor interactions at VEGFR2 using sunitinib-red and nanoBRET.

Probing expression of E-selectin using CRISPR-Cas9-mediated tagging with HiBiT in human endothelial cells (2023)
Journal Article
Ogrodzinski, L., Platt, S., Goulding, J., Alexander, C., Farr, T. D., Woolard, J., Hill, S. J., & Kilpatrick, L. E. (2023). Probing expression of E-selectin using CRISPR-Cas9-mediated tagging with HiBiT in human endothelial cells. iScience, 26(7), Article 107232. https://doi.org/10.1016/j.isci.2023.107232

E-selectin is expressed on endothelial cells in response to inflammatory cytokines and mediates leukocyte rolling and extravasation. However, studies have been hampered by lack of experimental approaches to monitor expression in real time in living c... Read More about Probing expression of E-selectin using CRISPR-Cas9-mediated tagging with HiBiT in human endothelial cells.

Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential (2023)
Journal Article
Tan, C. C. S., Trew, J., Peacock, T. P., Mok, K. Y., Hart, C., Lau, K., Ni, D., Orme, C. D. L., Ransome, E., Pearse, W. D., Coleman, C. M., Bailey, D., Thakur, N., Quantrill, J. L., Sukhova, K., Richard, D., Kahane, L., Woodward, G., Bell, T., Worledge, L., …Savolainen, V. (2023). Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential. Nature Communications, 14(1), 3322. https://doi.org/10.1038/s41467-023-38717-w

There has been limited characterisation of bat-borne coronaviruses in Europe. Here, we screened for coronaviruses in 48 faecal samples from 16 of the 17 bat species breeding in the UK, collected through a bat rehabilitation and conservationist networ... Read More about Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential.

The evolution and ecology of multiple antipredator defences (2023)
Journal Article
Kikuchi, D. W., Allen, W. L., Arbuckle, K., Aubier, T. G., Briolat, E. S., Burdfield-Steel, E. R., Cheney, K. L., Daňková, K., Elias, M., Hämäläinen, L., Herberstein, M. E., Hossie, T. J., Joron, M., Kunte, K., Leavell, B. C., Lindstedt, C., Lorioux‐Chevalier, U., McClure, M., McLellan, C. F., Medina, I., …Exnerová, A. (2023). The evolution and ecology of multiple antipredator defences. Journal of Evolutionary Biology, 36(7), 975-991. https://doi.org/10.1111/jeb.14192

Prey seldom rely on a single type of antipredator defence, often using multiple defences to avoid predation. In many cases, selection in different contexts may favour the evolution of multiple defences in a prey. However, a prey may use multiple defe... Read More about The evolution and ecology of multiple antipredator defences.

Endogenous CRISPR/Cas systems for genome engineering in the acetogens Acetobacterium woodii and Clostridium autoethanogenum (2023)
Journal Article
Poulalier-Delavelle, M., Baker, J. P., Millard, J., Winzer, K., & Minton, N. P. (2023). Endogenous CRISPR/Cas systems for genome engineering in the acetogens Acetobacterium woodii and Clostridium autoethanogenum. Frontiers in Bioengineering and Biotechnology, 11, Article 1213236. https://doi.org/10.3389/fbioe.2023.1213236

Acetogenic bacteria can play a major role in achieving Net Zero through their ability to convert CO2 into industrially relevant chemicals and fuels. Full exploitation of this potential will be reliant on effective metabolic engineering tools, such as... Read More about Endogenous CRISPR/Cas systems for genome engineering in the acetogens Acetobacterium woodii and Clostridium autoethanogenum.