Outputs (2639)

Alkyl-quinolone-dependent quorum sensing controls prophage-mediated autolysis in Pseudomonas aeruginosa colony biofilms (2023)
Journal Article
Giallonardi, G., Letizia, M., Mellini, M., Frangipani, E., Halliday, N., Heeb, S., Cámara, M., Visca, P., Imperi, F., Leoni, L., Williams, P., & Rampioni, G. (2023). Alkyl-quinolone-dependent quorum sensing controls prophage-mediated autolysis in Pseudomonas aeruginosa colony biofilms. Frontiers in Cellular and Infection Microbiology, 13, Article 1183681. https://doi.org/10.3389/fcimb.2023.1183681

Pseudomonas aeruginosa is a model quorum sensing (QS) pathogen with three interconnected QS circuits that control the production of virulence factors and antibiotic tolerant biofilms. The pqs QS system of P. aeruginosa is responsible for the biosynth... Read More about Alkyl-quinolone-dependent quorum sensing controls prophage-mediated autolysis in Pseudomonas aeruginosa colony biofilms.

Modelling spatiotemporal dynamics of cerebral blood flow using multiple-timepoint arterial spin labelling MRI (2023)
Journal Article
Pinto, J., Blockley, N. P., Harkin, J. W., & Bulte, D. P. (2023). Modelling spatiotemporal dynamics of cerebral blood flow using multiple-timepoint arterial spin labelling MRI. Frontiers in Physiology, 14, Article 1142359. https://doi.org/10.3389/fphys.2023.1142359

Introduction: Cerebral blood flow (CBF) is an important physiological parameter that can be quantified non-invasively using arterial spin labelling (ASL) imaging. Although most ASL studies are based on single-timepoint strategies, multi-timepoint app... Read More about Modelling spatiotemporal dynamics of cerebral blood flow using multiple-timepoint arterial spin labelling MRI.

Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes (2023)
Journal Article
Lay, C. S., Isidro-Llobet, A., Kilpatrick, L. E., Craggs, P. D., & Hill, S. J. (2023). Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes. Nature Communications, 14, Article 2882. https://doi.org/10.1038/s41467-023-38541-2

Association of single nucleotide polymorphisms in the IL-23 receptor with several auto-inflammatory diseases, led to the heterodimeric receptor and its cytokine-ligand IL-23, becoming important drug targets. Successful antibody-based therapies direct... Read More about Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes.

The role of reservoir species in mediating plague's dynamic response to climate (2023)
Journal Article
Fell, H. G., Jones, M., Atkinson, S., Stenseth, N. C., & Algar, A. C. (2023). The role of reservoir species in mediating plague's dynamic response to climate. Royal Society Open Science, 10(5), Article 230021. https://doi.org/10.1098/rsos.230021

The distribution and transmission of Yersinia pestis, the bacterial agent of plague, responds dynamically to climate, both within wildlife reservoirs and human populations. The exact mechanisms mediating plague's response to climate are still poorly... Read More about The role of reservoir species in mediating plague's dynamic response to climate.

Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38 (2023)
Journal Article
Armstrong, J. F., Campo, B., Alexander, S. P., Arendse, L. B., Cheng, X., Davenport, A. P., Faccenda, E., Fidock, D. A., Godinez‐Macias, K. P., Harding, S. D., Kato, N., Lee, M. C., Luth, M. R., Mazitschek, R., Mittal, N., Niles, J. C., Okombo, J., Ottilie, S., Pasaje, C. F. A., Probst, A. S., …Davies, J. A. (2023). Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38. British Journal of Pharmacology, 180(15), 1899-1929. https://doi.org/10.1111/bph.16144

Antimalarial drug discovery has until recently been driven by high-throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target-based approache... Read More about Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38.

Case Studies in Infectious Disease (2023)
Book
Lydyard, P., Cole, M., Holton, J., Irving, W., Porakishvili, N., Venkatesan, P., & Ward, K. (2023). Case Studies in Infectious Disease. (2nd edition). CRC Press. https://doi.org/10.1201/9781003155447

Case Studies in Infectious Disease presents 40 case studies featuring the most important human infectious diseases worldwide. Fully revised and updated in this second edition, the book describes the natural history of infection from point of entry of... Read More about Case Studies in Infectious Disease.

Disparities in care and outcomes for primary liver cancer in England during 2008–2018: a cohort study of 8.52 million primary care population using the QResearch database (2023)
Journal Article
Liao, W., Coupland, C. A., Innes, H., Jepsen, P., Matthews, P. C., Campbell, C., Barnes, E., Hippisley-Cox, J., Barnes, E., Culver, E., Fischer, R., Hippisley-Cox, J., Innes, H., Irving, W. L., Jepsen, P., Kelly, M., Klenerman, P., Liao, W., Mann, D., Marshall, A., …Welberry, C. (2023). Disparities in care and outcomes for primary liver cancer in England during 2008–2018: a cohort study of 8.52 million primary care population using the QResearch database. eClinicalMedicine, 59, Article 101969. https://doi.org/10.1016/j.eclinm.2023.101969

Background: Liver cancer has one of the fastest rising incidence and mortality rates among all cancers in the UK, but it receives little attention. This study aims to understand the disparities in epidemiology and clinical pathways of primary liver c... Read More about Disparities in care and outcomes for primary liver cancer in England during 2008–2018: a cohort study of 8.52 million primary care population using the QResearch database.

Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1 (2023)
Journal Article
Amambua-Ngwa, A., Button-Simons, K. A., Li, X., Kumar, S., Brenneman, K. V., Ferrari, M., Checkley, L. A., Haile, M. T., Shoue, D. A., McDew-White, M., Tindall, S. M., Reyes, A., Delgado, E., Dalhoff, H., Larbalestier, J. K., Amato, R., Pearson, R. D., Taylor, A. B., Nosten, F. H., D'Alessandro, U., …Anderson, T. J. (2023). Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1. Nature Microbiology, https://doi.org/10.1038/s41564-023-01377-z

Malaria parasites break down host haemoglobin into peptides and amino acids in the digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is central to the mode of action of several antimalarial drugs. Mutations... Read More about Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1.

RNA-Seq of untreated wastewater to assess COVID-19 and emerging and endemic viruses for public health surveillance (2023)
Journal Article
Stockdale, S. R., Blanchard, A. M., Nayak, A., Husain, A., Nashine, R., Dudani, H., McClure, C. P., Tarr, A. W., Nag, A., Meena, E., Sinha, V., Shrivastava, S. K., Hill, C., Singer, A. C., Gomes, R. L., Acheampong, E., Chidambaram, S. B., Bhatnagar, T., Vetrivel, U., Arora, S., …Monaghan, T. M. (2023). RNA-Seq of untreated wastewater to assess COVID-19 and emerging and endemic viruses for public health surveillance. The Lancet Regional Health – Southeast Asia, 14, Article 100205. https://doi.org/10.1016/j.lansea.2023.100205

Background: The COVID-19 pandemic showcased the power of genomic sequencing to tackle the emergence and spread of infectious diseases. However, metagenomic sequencing of total microbial RNAs in wastewater has the potential to assess multiple infectio... Read More about RNA-Seq of untreated wastewater to assess COVID-19 and emerging and endemic viruses for public health surveillance.

Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate (2023)
Journal Article
Bardelang, P., Murray, E. J., Blower, I., Zandomeneghi, S., Goode, A., Hussain, R., Kumari, D., Siligardi, G., Inoue, K., Luckett, J., Doutch, J., Emsley, J., Chan, W. C., Hill, P., Williams, P., & Bonev, B. B. (2023). Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate. Frontiers in Chemistry, 11, Article 1113885. https://doi.org/10.3389/fchem.2023.1113885

Virulence gene expression in the human pathogen, S. aureus is regulated by the agr (accessory gene regulator) quorum sensing (QS) system which is conserved in diverse Gram-positive bacteria. The agr QS signal molecule is an autoinducing peptide (AIP)... Read More about Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate.