Outputs (30)

Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells (2015)
Journal Article
Jean-Gilles, L., Braitch, M., Latif, M. L., Aram, J., Fahey, A. J., Edwards, L. J., …Constantinescu, C. S. (2015). Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells. Acta Physiologica, 214(1), 63-74. https://doi.org/10.1111/apha.12474

© 2015 The Authors. Aims: To investigate the regulation of cannabinoid receptors CB1 and CB2 on immune cells by pro-inflammatory cytokines and its potential relevance to the inflammatory neurological disease, multiple sclerosis (MS). CB1 and CB2 sign... Read More about Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells.

Effects of NAD at purine receptors in isolated blood vessels (2014)
Journal Article
Alefishat, E., Alexander, S. P., & Ralevic, V. (2015). Effects of NAD at purine receptors in isolated blood vessels. Purinergic Signalling, 11(1), https://doi.org/10.1007/s11302-014-9428-1

Nicotinamide adenine dinucleotide (NAD) belongs to the family of naturally occurring adenine dinucleotides, best known for their various intracellular roles. However, there is evidence that they can also be released from cells to act as novel extrace... Read More about Effects of NAD at purine receptors in isolated blood vessels.

A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries (2014)
Journal Article
Wong, P., Garle, M., Alexander, S., Randall, M., & Roberts, R. (2014). A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries. Pharmacological Research, 90, https://doi.org/10.1016/j.phrs.2014.09.004

Hydrogen peroxide (H2O2) has been proposed to act as a factor for endothelium-derived hyperpolar-ization (EDH) and EDH may act as a ‘back up’ system to compensate the loss of the NO pathway. Here,the mechanism of action of H2O2in porcine isolated cor... Read More about A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries.

The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes (2014)
Journal Article
Cable, J. C., Tan, G. D., Alexander, S. P., & O'Sullivan, S. E. (2014). The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes. Lipids in Health and Disease, 13(1), Article 43. https://doi.org/10.1186/1476-511X-13-43

Background: Circulating endocannabinoid levels are increased in obesity and diabetes. We have shown that fatty acid amide hydrolase (FAAH, an endocannabinoid hydrolysing enzyme) in subcutaneous adipose tissue positively correlates with BMI in healthy... Read More about The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes.

Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat (2014)
Journal Article
Gaskin, P. L., Fone, K., & Alexander, S. (2014). Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat. Psychopharmacology, 231(12), 2533-2545. https://doi.org/10.1007/s00213-013-3424-y

Rationale: Schizophrenia is a debilitating disorder comprising positive, negative and cognitive deficits with a poorly defined neurobiological aetiology; therefore, animal models with greater translational reliability are essential to develop improve... Read More about Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat.

Effects of the A2A adenosine receptor antagonist KW6002 in the nucleus accumbens in vitro and in vivo (2006)
Journal Article
Harper, L. K., Beckett, S. R., Marsden, C. A., McCreary, A. C., & Alexander, S. P. (2006). Effects of the A2A adenosine receptor antagonist KW6002 in the nucleus accumbens in vitro and in vivo. Pharmacology Biochemistry and Behavior, 83(1), 114-121. https://doi.org/10.1016/j.pbb.2005.12.014

In this study, we have used the selective A2A adenosine receptor antagonist KW6002 to investigate the function of A2A receptors in the Lister hooded rat nucleus accumbens in vitro and in vivo. Radioligand binding studies confirmed a greater than 50-f... Read More about Effects of the A2A adenosine receptor antagonist KW6002 in the nucleus accumbens in vitro and in vivo.

A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening (2005)
Journal Article
De Bank, P. A., Kendall, D. A., & Alexander, S. P. (2005). A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening. Biochemical Pharmacology, 69(8), 1187-1193. https://doi.org/10.1016/j.bcp.2005.01.012

Signalling via the endocannabinoids anandamide and 2-arachidonylglycerol appears to be terminated largely through the action of the enzyme fatty acid amide hydrolase (FAAH). In this report, we describe a simple spectrophotometric assay to detect FAAH... Read More about A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening.

The cellular localization of adenosine receptors in rat neostriatum (1989)
Journal Article
Alexander, S. P., & Reddington, M. (1989). The cellular localization of adenosine receptors in rat neostriatum. Neuroscience, 28(3), 645-651. https://doi.org/10.1016/0306-4522%2889%2990011-0

Using quantitative autoradiography of ligand binding sites combined with lesions of specific neuronal pathways, the cellular locations of A1 and A2 adenosine receptors, as well as a third binding site for the adenosine receptor ligand, [3H]N-ethylcar... Read More about The cellular localization of adenosine receptors in rat neostriatum.

Comparison of amine modifiers used to reduce peak tailing of 2-phenylethylamine drugs in reversed-phase high-performance liquid chromatography (1982)
Journal Article
Gill, R., Alexander, S. P., & Moffat, A. C. (1982). Comparison of amine modifiers used to reduce peak tailing of 2-phenylethylamine drugs in reversed-phase high-performance liquid chromatography. Journal of Chromatography A, 247(1), 39-45. https://doi.org/10.1016/S0021-9673%2800%2984854-2

Chromatographic retention and peak shapes for a group of five 2-phenylethylamine drugs in reversed-phase high-performance liquid chromatography have been examined with a series of eluents containing various amines as part of the buffer system. An ODS... Read More about Comparison of amine modifiers used to reduce peak tailing of 2-phenylethylamine drugs in reversed-phase high-performance liquid chromatography.

Group-contribution approach to the behaviour of 2-phenyl-ethylamines in reversed-phase high-performance liquid chromatography (1981)
Journal Article
Gill, R., Alexander, S. P., & Moffat, A. C. (1981). Group-contribution approach to the behaviour of 2-phenyl-ethylamines in reversed-phase high-performance liquid chromatography. Journal of Chromatography A, 218(C), 639-646. https://doi.org/10.1016/S0021-9673%2800%2982089-0

High-performance liquid chromatography retention data are reported for 2-phenylethylamine and 30 of its derivatives, including examples of CH3 OH, OCH3, COOH, NH2 and N-oxide substitution. An octadecyl-silica column was used with an eluent of 10% met... Read More about Group-contribution approach to the behaviour of 2-phenyl-ethylamines in reversed-phase high-performance liquid chromatography.