Shape-related characteristics of age-related differences in subcortical structures (2018)
Journal Article

OBJECTIVES: With an increasing aging population, it is important to gain a better understanding of biological markers of aging. Subcortical volume is known to differ with age; additionally considering shape-related characteristics may provide a bette... Read More about Shape-related characteristics of age-related differences in subcortical structures.

Patterns of grey matter loss associated with motor subscores in early Parkinson's disease (2017)
Journal Article

Classical motor symptoms of Parkinson's disease (PD) such as tremor, rigidity, bradykinesia, and axial symptoms are graded in the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III. It is yet to be ascertained whether... Read More about Patterns of grey matter loss associated with motor subscores in early Parkinson's disease.

Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank (2017)
Journal Article

UK Biobank is a large-scale prospective epidemiological study with all data accessible to researchers worldwide. It is currently in the process of bringing back 100,000 of the original participants for brain, heart and body MRI, carotid ultrasound an... Read More about Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank.

The heritability of multi-modal connectivity in human brain activity (2017)
Journal Article

Patterns of intrinsic human brain activity exhibit a profile of functional connectivity that is associated with behaviour and cognitive performance, and deteriorates with disease. This paper investigates the relative importance of genetic factors and... Read More about The heritability of multi-modal connectivity in human brain activity.

Subthalamic deep brain stimulation sweet spots and hyperdirect cortical connectivity in Parkinson’s disease (2017)
Journal Article

Objectives Firstly, to identify subthalamic region stimulation clusters that predict maximum improvement in rigidity, bradykinesia and tremor, or emergence of side-effects; and secondly, to map-out the cortical fingerprint, mediated by the hyperdire... Read More about Subthalamic deep brain stimulation sweet spots and hyperdirect cortical connectivity in Parkinson’s disease.

Improved tractography using asymmetric fibre orientation distributions (2017)
Journal Article

Diffusion MRI allows us to make inferences on the structural organisation of the brain by mapping water diffusion to white matter microstructure. However, such a mapping is generally ill-defined; for instance, diffusion measurements are antipodally s... Read More about Improved tractography using asymmetric fibre orientation distributions.

Building connectomes using diffusion MRI: why, how and but (2017)
Journal Article

Why has diffusion MRI become a principal modality for mapping connectomes in vivo? How do different image acquisition parameters, fiber tracking algorithms and other methodological choices affect connectome estimation? What are the main factors that... Read More about Building connectomes using diffusion MRI: why, how and but.

Evaluating fibre orientation dispersion in white matter: comparison of diffusion MRI, histology and polarized light imaging (2017)
Journal Article

Diffusion MRI is an exquisitely sensitive probe of tissue microstructure, and is currently the only non-invasive measure of the brain’s fibre architecture. As this technique becomes more sophisticated and microstructurally informative, there is incre... Read More about Evaluating fibre orientation dispersion in white matter: comparison of diffusion MRI, histology and polarized light imaging.

Time-efficient and flexible design of optimized multishell HARDI diffusion (2017)
Journal Article

Purpose: Advanced diffusion magnetic resonance imaging benefits from collecting as much data as is feasible but is highly sensitive to subject motion and the risk of data loss increases with longer acquisition times. Our purpose was to create a maxim... Read More about Time-efficient and flexible design of optimized multishell HARDI diffusion.

Image quality transfer and applications in diffusion MRI (2017)
Journal Article

This paper introduces a new computational imaging technique called image quality transfer (IQT). IQT uses machine learning to transfer the rich information available from one-off experimental medical imaging devices to the abundant but lower-quality... Read More about Image quality transfer and applications in diffusion MRI.

Studying neuroanatomy using MRI (2017)
Journal Article

The study of neuroanatomy using imaging enables key insights into how our brains function, are shaped by genes and environment, and change with development, aging, and disease. Developments in MRI acquisition, image processing, and data modelling hav... Read More about Studying neuroanatomy using MRI.

In Vivo Assessment of Brainstem Depigmentation in Parkinson Disease: Potential as a Severity Marker for Multicenter Studies (2016)
Journal Article

Purpose: To investigate the pattern of neuromelanin signal intensity loss within the substantia nigra pars compacta (SNpc), locus coeruleus, and ventral tegmental area in Parkinson disease (PD); the specific aims were (a) to study regional magnetic... Read More about In Vivo Assessment of Brainstem Depigmentation in Parkinson Disease: Potential as a Severity Marker for Multicenter Studies.