Professor Nigel Mongan's Outputs (128)

A Key Genomic Subtype Associated with Lymphovascular Invasion in Invasive Breast Cancer (2019)
Journal Article
Kurozumi, S., Joseph, C., Alsaeed, S., Kariri, Y., Aljohani, A., Raafat, S., Alsaleem, M., Ogden, A., Johnston, S., Aleskandarany, M. A., Fujii, T., Shirabe, K., Caldas, C., Ashankyty, I., Dalton, L., Ellis, I. O., Desmedt, C., Green, A. R., Mongan, N. P., & Rakha, E. A. (2019). A Key Genomic Subtype Associated with Lymphovascular Invasion in Invasive Breast Cancer. British Journal of Cancer, 120(12), 1129–1136. https://doi.org/10.1038/s41416-019-0486-6

Background: Lymphovascular invasion (LVI) is associated with the development of metastasis in invasive breast cancer (BC). However, the complex molecular mechanisms of LVI, which overlap with other oncogenic pathways, remain unclear. This study, usin... Read More about A Key Genomic Subtype Associated with Lymphovascular Invasion in Invasive Breast Cancer.

A Fibromyxoid Stromal Response is Associated with Muscle Invasion in Canine Urothelial Carcinoma (2019)
Journal Article
de Brot, S., Grau-Roma, L., Stirling-Stainsby, C., Dettwiler, M., Guscetti, F., Meier, D., Scase, T., Robinson, B., Gardner, D., & Mongan, N. (2019). A Fibromyxoid Stromal Response is Associated with Muscle Invasion in Canine Urothelial Carcinoma. Journal of Comparative Pathology, 169, 35-46. https://doi.org/10.1016/j.jcpa.2019.04.003

Canine urothelial carcinoma (UC) is the most common type of cancer of the lower urinary tract and tends to affect elderly neutered female dogs, with a high predisposition for Scottish terriers. Tumour stroma, inflammation and necrosis are poorly char... Read More about A Fibromyxoid Stromal Response is Associated with Muscle Invasion in Canine Urothelial Carcinoma.

Metadherin: A Therapeutic Target in Multiple Cancers (2019)
Journal Article
Dhiman, G., Srivastava, N., Goyal, M., Rakha, E., Lothion-Roy, J., Mongan, N. P., Miftakhova, R. R., Khaiboullina, S. F., Rizvanov, A. A., & Baranwal, M. (2019). Metadherin: A Therapeutic Target in Multiple Cancers. Frontiers in Oncology, 9, Article 349. https://doi.org/10.3389/fonc.2019.00349

Altered expression of many genes and proteins is essential for cancer development and progression. Recently, the affected expression of metadherin (MTDH), also known as AEG-1 (Astrocyte Elevated Gene 1) and Lyric, has been implicated in various aspec... Read More about Metadherin: A Therapeutic Target in Multiple Cancers.

Detection and analysis of RNA methylation (2019)
Journal Article
Mongan, N. P., Emes, R. D., & Archer, N. (2019). Detection and analysis of RNA methylation. F1000Research, 8, 559. https://doi.org/10.12688/f1000research.17956.1

© 2019 Mongan NP et al. Our understanding of the expanded genetic alphabet has been growing rapidly over the last two decades, and many of these developments came more than 80 years after the original discovery of a modified guanine in tuberculosis D... Read More about Detection and analysis of RNA methylation.

Utility of Ankyrin 3 as a Prognostic Marker in Androgen-Receptor-Positive Breast Cancer Running Title: Prognostic Value of ANK3 in AR-Positive Breast Cancer (2019)
Journal Article
Kurozumi, S., Joseph, C., Raafat, S., Sonbul, S., Kariri, Y., Alsaeed, S., Pigera, M., Alsaleem, M., Nolan, C. C., Johnston, S., Aleskandarany, M. A., Ogden, A., Fujii, T., Shirabe, K., Martin, S., Alshankyty, I., Mongan, N. P., Ellis, I. O., Green, A. R., & Rakha, E. A. (2019). Utility of Ankyrin 3 as a Prognostic Marker in Androgen-Receptor-Positive Breast Cancer Running Title: Prognostic Value of ANK3 in AR-Positive Breast Cancer. Breast Cancer Research and Treatment, 176(1), 63–73. https://doi.org/10.1007/s10549-019-05216-w

© 2019, Springer Science+Business Media, LLC, part of Springer Nature. Purpose: Androgen receptor (AR) and AR signaling pathways are thought to play a role in breast cancer (BC) and are potentially related to treatment responses and outcomes. Ankyrin... Read More about Utility of Ankyrin 3 as a Prognostic Marker in Androgen-Receptor-Positive Breast Cancer Running Title: Prognostic Value of ANK3 in AR-Positive Breast Cancer.

The molecular mechanisms underlying reduced E-cadherin expression in invasive ductal carcinoma of the breast: high throughput analysis of large cohorts (2019)
Journal Article
Rida, P. C. G., Alsaleem, M., Toss, M. S., Joseph, C., Aleskandarany, M., Kurozumi, S., Alshankyty, I., Ogden, A., Rida, P. C., Ellis, I. O., Aneja, R., Green, A. R., Mongan, N. P., & Rakha, E. A. (2019). The molecular mechanisms underlying reduced E-cadherin expression in invasive ductal carcinoma of the breast: high throughput analysis of large cohorts. Modern Pathology, 32(7), 967-976. https://doi.org/10.1038/s41379-019-0209-9

© 2019, United States & Canadian Academy of Pathology. E-cadherin is a tumor suppressor gene in invasive lobular breast cancer. However, a proportion of high-grade ductal carcinoma shows reduced/loss of E-cadherin. In this study, we assessed the un... Read More about The molecular mechanisms underlying reduced E-cadherin expression in invasive ductal carcinoma of the breast: high throughput analysis of large cohorts.

Overexpression of the cancer stem cell marker CD133 confers a poor prognosis in invasive breast cancer (2018)
Journal Article
Joseph, C., Arshad, M., Kurozomi, S., Althobiti, M., Miligy, I. M., Al-Izzi, S., Toss, M. S., Goh, F. Q., Johnston, S. J., Martin, S. G., Ellis, I. O., Mongan, N. P., Green, A. R., & Rakha, E. A. (2019). Overexpression of the cancer stem cell marker CD133 confers a poor prognosis in invasive breast cancer. Breast Cancer Research and Treatment, 174(2), 387-399. https://doi.org/10.1007/s10549-018-05085-9

Purpose
CD133/ prominin 1 is a cancer stem cell marker associated with cancer progression and patient outcome in a variety of solid tumours, but its role in invasive breast cancer (BC) remains obscure. The current study aims to assess the prognostic... Read More about Overexpression of the cancer stem cell marker CD133 confers a poor prognosis in invasive breast cancer.

Predicting puberty in partial androgen insensitivity syndrome: use of clinical and functional androgen receptor indices (2018)
Journal Article
Lek, N., Tadokoro-Cuccaro, R., Whitchurch, J. B., Mazumder, B., Miles, H., Prentice, P., Bunch, T., Zielińska, K., Metzler, V. M., Mongan, N. P., Heery, D. M., & Hughes, I. A. (2018). Predicting puberty in partial androgen insensitivity syndrome: use of clinical and functional androgen receptor indices. EBioMedicine, 36, 401-409. https://doi.org/10.1016/j.ebiom.2018.09.047

CARM1 (PRMT4) acts as a transcriptional coactivator during retinoic acid-induced embryonic stem cell differentiation (2018)
Journal Article
Quintero, C. M., Laursen, K. B., Mongan, N. P., Luo, M., & Gudas, L. J. (2018). CARM1 (PRMT4) acts as a transcriptional coactivator during retinoic acid-induced embryonic stem cell differentiation. Journal of Molecular Biology, 430(21), 4168-4182. https://doi.org/10.1016/j.jmb.2018.08.014

Activation of the retinoic acid (RA) signaling pathway is important for controlling embryonic stem cell differentiation and development. Modulation of this pathway occurs through the recruitment of different epigenetic regulators at the retinoic acid... Read More about CARM1 (PRMT4) acts as a transcriptional coactivator during retinoic acid-induced embryonic stem cell differentiation.

The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor (2018)
Journal Article
Sarwar, M., Syed Khaja, A. S., Aleskandarany, M., Karlsson, R., Althobiti, M., Ødum, N., Mongan, N. P., Dizeyi, N., Johnson, H., Green, A. R., Ellis, I. O., Rakha, E. A., & Persson, J. L. (2019). The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor. Oncogene, 38(3), 375-389. https://doi.org/10.1038/s41388-018-0438-2

© 2018, The Author(s). Despite recent improvement in adjuvant therapies, triple-negative, and ER + subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. We investigated the role of phosphatidylinosi... Read More about The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor.

Clinicopathological and prognostic significance of Ras association and pleckstrin homology domains 1 (RAPH1) in breast cancer (2018)
Journal Article
Kurozumi, S., Joseph, C., Sonbul, S., Aleskandarany, M. A., Pigera, M., Alsaleem, M., Alsaeed, S., Kariri, Y., Nolan, C. C., Diez-Rodriguez, M., Johnston, S., Mongan, N. P., Fujii, T., Shirabe, K., Martin, S. G., Ellis, I. O., Green, A. R., & Rakha, E. A. (2018). Clinicopathological and prognostic significance of Ras association and pleckstrin homology domains 1 (RAPH1) in breast cancer. Breast Cancer Research and Treatment, 172(1), 61–68. https://doi.org/10.1007/s10549-018-4891-y

BACKGROUND: Ras association and pleckstrin homology domains 1 (RAPH1) is involved in cytoskeleton regulation and re-epithelialisation in invasive carcinoma and therefore may play a key role in carcinogenesis and metastasis. We herein investigated the... Read More about Clinicopathological and prognostic significance of Ras association and pleckstrin homology domains 1 (RAPH1) in breast cancer.

Impact of breast cancer grade discordance on prediction of outcome (2018)
Journal Article
Rakha, E. A., Aleskandarany, M. A., Toss, M. S., Mongan, N., El-Sayed, M. E., Green, A. R., Ellis, I. O., & Dalton, L. W. (in press). Impact of breast cancer grade discordance on prediction of outcome. Histopathology, https://doi.org/10.1111/his.13709

BACKGROUND: Histological grade is an independent prognostic variable in breast cancer (BC). Previous concordance studies of BC grade have reported moderate levels of agreement; a typical finding in morphological assessment of biological variables. Th... Read More about Impact of breast cancer grade discordance on prediction of outcome.

Heterogeneity of Tumour Infiltrating Lymphocytes (TILs) in breast cancer and its prognostic significance (2018)
Journal Article
Althobiti, M., Aleskandarany, M. A., Joseph, C., Toss, M., Mongan, N., Diez-Rodriguez, M., Nolan, C. C., Ashankyty, I., Ellis, I. O., Green, A. R., & Rakha, E. A. (2018). Heterogeneity of Tumour Infiltrating Lymphocytes (TILs) in breast cancer and its prognostic significance. Histopathology, 73(6), 887-896. https://doi.org/10.1111/his.13695

Background: Tumour-infiltrating lymphocytes (TILs) in breast cancer (BC) confer prognostic and predictive information. This study aims to assess the spatial and temporal heterogeneity of TILs in BC and its relationship with immune cell subtypes.
Met... Read More about Heterogeneity of Tumour Infiltrating Lymphocytes (TILs) in breast cancer and its prognostic significance.

The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology (2018)
Journal Article
de Brot, S., Robinson, B. D., Scase, T., Grau‑Roma, L., Wilkinson, E., Boorjian, S. A., Gardner, D. S., & Mongan, N. P. (2018). The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology. Oncology Letters, 16(2), https://doi.org/10.3892/ol.2018.8837

Despite the recent approval of several novel agents for patients with metastatic urothelial carcinoma (UC), survival in this setting remains poor. As such, continued investigation into novel therapeutic options remains warranted. Pre clinical develop... Read More about The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology.

Peri-conception and first trimester diet modifies reproductive development in bulls (2017)
Journal Article
Copping, K. J., Ruiz-Diaz, M. D., Rutland, C. S., Mongan, N. P., Callaghan, M., McMillen, I. C., Rodgers, R. J., & Perry, V. (in press). Peri-conception and first trimester diet modifies reproductive development in bulls. Reproduction, Fertility and Development, https://doi.org/10.1071/RD17102

Nutritional perturbation during gestation alters male reproductive development in rodents and sheep. In cattle both the developmental trajectory of the feto–placental unit and its response to dietary perturbations is dissimilar to that of these speci... Read More about Peri-conception and first trimester diet modifies reproductive development in bulls.

Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics (2017)
Journal Article
Simpson, S., Dunning, M. D., de Brot, S., Grau-Roma, L., Mongan, N. P., & Rutland, C. S. (2017). Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics. Acta Veterinaria Scandinavica, 59, Article 71. https://doi.org/10.1186/s13028-017-0341-9

Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are 27 times higher than in people. Prognosis in both species is poor, with five year osteosarcoma survival rates in people not having improved in decades. For dogs, o... Read More about Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics.

Epigenetic control of microRNA expression and cancer (2017)
Book Chapter
De Brot, S., Rutland, C. S., Mongan, N. P., & James, V. (2018). Epigenetic control of microRNA expression and cancer. In J. Chakrabarti, & S. Mitra (Eds.), Cancer and Noncoding RNAs (373-380). Elsevier. https://doi.org/10.1016/B978-0-12-811022-5.00020-6

MicroRNAs (miRNAs or miRs) are involved in pathways central to homeostasis and cellular function, including proliferation, differentiation, and apoptosis; processes which when aberrantly regulated contribute to the hallmarks of cancer. The contributi... Read More about Epigenetic control of microRNA expression and cancer.

Heterochromatin modulation and PCG control of gene expression mediated by noncoding RNA in cancer (2017)
Book Chapter
Rutland, C. S., de Brot, S., James, V., & Mongan, N. P. (2018). Heterochromatin modulation and PCG control of gene expression mediated by noncoding RNA in cancer. In J. Chakrabarti, & S. Mitra (Eds.), Cancer and Noncoding RNAs (359-372). Elsevier. https://doi.org/10.1016/b978-0-12-811022-5.00019-x

In eukaryotes, the packaging of DNA and proteins, termed chromatin, is an essential determinant of transcription. The basic unit of chromatin, the nucleosome, is composed of ∼146 base pairs of DNA spooled around a dense protein core containing two co... Read More about Heterochromatin modulation and PCG control of gene expression mediated by noncoding RNA in cancer.

Parental protein malnutrition programmes of offspring growth and vasculature to increase risk of cardiovascular, pancreatic, and metabolic disease: lessons learned from animal studies (2017)
Journal Article
Ruiz-Diaz, M. D., Partridge, H., Davidson, F., Mongan, N. P., Gardner, D. S., & Rutland, C. S. (2017). Parental protein malnutrition programmes of offspring growth and vasculature to increase risk of cardiovascular, pancreatic, and metabolic disease: lessons learned from animal studies. European Medical Journal Reproductive Health, 3(1),

It is well known that consumption of a balanced diet throughout adulthood is key toward maintenance of optimal body weight and cardiovascular health. Research using animal models can provide insights into the programming of short and long-term health... Read More about Parental protein malnutrition programmes of offspring growth and vasculature to increase risk of cardiovascular, pancreatic, and metabolic disease: lessons learned from animal studies.

Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells (2017)
Journal Article
Gomzikova, M., Zhuravleva, M., Miftakhova, R., Arkhipova, S., Evtugin, V., Khaiboullina, S., Kiyasov, A., Persson, J., Mongan, N. P., Pestell, R., & Rizvanov, A. A. (2017). Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells. Oncotarget, 8(41), https://doi.org/10.18632/oncotarget.19723

Naturally occurring extracellular vesicles (EVs) play essential roles in intracellular communication and delivery of bioactive molecules. Therefore it has been suggested that EVs could be used for delivery of therapeutics. However, to date the therap... Read More about Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells.