Skip to main content

Research Repository

Advanced Search

Epigenetic control of microRNA expression and cancer

De Brot, Simone; Rutland, Catrin S.; Mongan, Nigel P.; James, Victoria


Simone De Brot

Professor of Oncology


Jayprokas Chakrabarti

Sanga Mitra


MicroRNAs (miRNAs or miRs) are involved in pathways central to homeostasis and cellular function, including proliferation, differentiation, and apoptosis; processes which when aberrantly regulated contribute to the hallmarks of cancer. The contribution of miRNAs to normal cellular function is often context dependent and the same is true of miRNA function in cancer; with the action of miRNAs as oncomiRs or tumor suppressor miRs often being dependent upon the tissue type and the cellular context of their expression. Alteration of miRNA expression via mutations and epigenetic modification is frequently seen in cancer at both early and more progressive stages. In this chapter, we will discuss the altered pattern of epigenetic regulation of miRNAs and their regulatory machinery as well as the potential impact of epigenetic drugs.

Book Type Authored Book
Acceptance Date Mar 15, 2017
Online Publication Date Oct 13, 2017
Publication Date Jul 18, 2018
Deposit Date Dec 6, 2018
Publisher Elsevier
Pages 373-380
Series Title Translational Epigenetics
Series Number 1
Book Title Cancer and Noncoding RNAs
Chapter Number 20
ISBN 9780128110225
Public URL
Publisher URL