Epigenetic control of microRNA expression and cancer

De Brot, Simone; Rutland, Catrin S.; Mongan, Nigel P.; James, Victoria

Abstract

MicroRNAs (miRNAs or miRs) are involved in pathways central to homeostasis and cellular function, including proliferation, differentiation, and apoptosis; processes which when aberrantly regulated contribute to the hallmarks of cancer. The contribution of miRNAs to normal cellular function is often context dependent and the same is true of miRNA function in cancer; with the action of miRNAs as oncomiRs or tumor suppressor miRs often being dependent upon the tissue type and the cellular context of their expression. Alteration of miRNA expression via mutations and epigenetic modification is frequently seen in cancer at both early and more progressive stages. In this chapter, we will discuss the altered pattern of epigenetic regulation of miRNAs and their regulatory machinery as well as the potential impact of epigenetic drugs.

Citation

De Brot, S., Rutland, C. S., Mongan, N. P., & James, V. (2018). Epigenetic control of microRNA expression and cancer. In J. Chakrabarti, & S. Mitra (Eds.), Cancer and Noncoding RNAs, 373-380. Elsevier. doi:10.1016/B978-0-12-811022-5.00020-6

• Book Type: Authored Book
• Acceptance Date: Mar 15, 2017
• Online Publication Date: Oct 13, 2017
• Publication Date: Jul 18, 2018
• Deposit Date: Dec 6, 2018
• Publisher: Elsevier
• Pages: 373-380
• Series Title: Translational Epigenetics
• Series Number: 1
• Book Title: Cancer and Noncoding RNAs
• Chapter Number: 20
• ISBN: 9780128110225
• DOI: https://doi.org/10.1016/B978-0-12-811022-5.00020-6
• Public URL: https://nottingham-repository.worktribe.com/output/1378131
• Publisher URL: https://www.sciencedirect.com/science/article/pii/B9780128110225000206