The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology

de Brot, Simone; Robinson, Brian D.; Scase, Tim; Grau‑Roma, Llorenç; Wilkinson, Eleanor; Boorjian, Stephen A.; Gardner, David S.; Mongan, Nigel P.

Abstract

Despite the recent approval of several novel agents for patients with metastatic urothelial carcinoma (UC), survival in this setting remains poor. As such, continued investigation into novel therapeutic options remains warranted. Pre clinical development of novel treatments requires an animal model that accurately simulates the disease in humans. The aim of the present study was to evaluate the dog as an animal model for human UC. A total of 260 cases of spontaneous, untreated canine primary urethral and urinary bladder UC, were epide¬miologically and histologically assessed and classified based on the current 2016 World Health Organization (WHO) tumor classification system. Canine data was compared with human data available from scientific literature. The mean age of dogs diagnosed with UC was 10.22 years (range, 4 15 years), which is equivalent to 60 70 human years. The results revealed a high association between UC diagnosis with the female sex [odds ratio (OR) 3.51; 95% confidence interval (CI) 2.57 4.79; P

Citation

de Brot, S., Robinson, B. D., Scase, T., Grau‑Roma, L., Wilkinson, E., Boorjian, S. A., …Mongan, N. P. (2018). The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology. Oncology Letters, 16(2), https://doi.org/10.3892/ol.2018.8837

• Journal Article Type: Article
• Acceptance Date: Feb 21, 2018
• Online Publication Date: May 30, 2018
• Publication Date: Aug 31, 2018
• Deposit Date: Mar 5, 2018
• Publicly Available Date: May 30, 2018
• Journal: Oncology Letters
• Print ISSN: 1792-1074
• Electronic ISSN: 1792-1082
• Publisher: Spandidos Publications
• Peer Reviewed: Peer Reviewed
• Volume: 16
• Issue: 2
• DOI: https://doi.org/10.3892/ol.2018.8837
• Keywords: Urothelial carcinoma; Bladder; Urethra; Dog; Animal model
• Public URL: https://nottingham-repository.worktribe.com/output/949827
• Publisher URL: https://www.spandidos-publications.com/10.3892/ol.2018.8837