Research Repository

See what's under the surface

The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology

de Brot, Simone; Robinson, Brian D.; Scase, Tim; Grau‑Roma, Llorenç; Wilkinson, Eleanor; Boorjian, Stephen A.; Gardner, David S.; Mongan, Nigel P.

Authors

Simone de Brot

Brian D. Robinson

Tim Scase

Llorenç Grau‑Roma

Eleanor Wilkinson

Stephen A. Boorjian

Nigel P. Mongan

Abstract

Despite the recent approval of several novel agents for patients with metastatic urothelial carcinoma (UC), survival in this setting remains poor. As such, continued investigation into novel therapeutic options remains warranted. Pre clinical development of novel treatments requires an animal model that accurately simulates the disease in humans. The aim of the present study was to evaluate the dog as an animal model for human UC. A total of 260 cases of spontaneous, untreated canine primary urethral and urinary bladder UC, were epide¬miologically and histologically assessed and classified based on the current 2016 World Health Organization (WHO) tumor classification system. Canine data was compared with human data available from scientific literature. The mean age of dogs diagnosed with UC was 10.22 years (range, 4 15 years), which is equivalent to 60 70 human years. The results revealed a high association between UC diagnosis with the female sex [odds ratio (OR) 3.51; 95% confidence interval (CI) 2.57 4.79; P

Journal Article Type Article
Publication Date Aug 31, 2018
Journal Oncology Letters
Print ISSN 1792-1074
Electronic ISSN 1792-1082
Publisher Spandidos Publications
Peer Reviewed Peer Reviewed
Volume 16
Issue 2
Institution Citation de Brot, S., Robinson, B. D., Scase, T., Grau‑Roma, L., Wilkinson, E., Boorjian, S. A., …Mongan, N. P. (2018). The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology. Oncology Letters, 16(2), doi:10.3892/ol.2018.8837
DOI https://doi.org/10.3892/ol.2018.8837
Keywords Urothelial carcinoma; Bladder; Urethra; Dog; Animal model
Publisher URL https://www.spandidos-publications.com/10.3892/ol.2018.8837
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

Files

bladder ol.2018.8837_AOP_PDF.pdf (2 Mb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0




You might also like


Downloadable Citations