Marina Gomzikova
Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells
Gomzikova, Marina; Zhuravleva, Margarita; Miftakhova, Regina; Arkhipova, Svetlana; Evtugin, Vladimir; Khaiboullina, Sventlana; Kiyasov, Andrey; Persson, Jenny; Mongan, Nigel P.; Pestell, Richard; Rizvanov, Albert A.
Authors
Margarita Zhuravleva
Regina Miftakhova
Svetlana Arkhipova
Vladimir Evtugin
Sventlana Khaiboullina
Andrey Kiyasov
Jenny Persson
NIGEL MONGAN nigel.mongan@nottingham.ac.uk
Professor of Oncology
Richard Pestell
Albert A. Rizvanov
Abstract
Naturally occurring extracellular vesicles (EVs) play essential roles in intracellular communication and delivery of bioactive molecules. Therefore it has been suggested that EVs could be used for delivery of therapeutics. However, to date the therapeutic application of EVs has been limited by number of factors, including limited yield and full understanding of their biological activities. To address these issues, we analyzed the morphology, molecular composition, fusion capacity and biological activity of Cytochalasin B-induced membrane vesicles (CIMVs). The size of these vesicles was comparable to that of naturally occurring EVs. In addition, we have shown that CIMVs from human SH-SY5Y cells contain elevated levels of VEGF as compared to the parental cells, and stimulate angiogenesis in vitro and in vivo.
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 17, 2017 |
Publication Date | Jul 31, 2017 |
Deposit Date | Aug 4, 2017 |
Publicly Available Date | Aug 4, 2017 |
Journal | Oncotarget |
Electronic ISSN | 1949-2553 |
Publisher | Impact Journals |
Peer Reviewed | Peer Reviewed |
Volume | 8 |
Issue | 41 |
DOI | https://doi.org/10.18632/oncotarget.19723 |
Keywords | extracellular vesicles, membrane vesicles, Cytochalasin B-induced membrane vesicles, angiogenesis, cell-free therapy |
Public URL | https://nottingham-repository.worktribe.com/output/874988 |
Publisher URL | http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=19723&path[]=63002 |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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