Skip to main content

Research Repository

Advanced Search

Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells

Gomzikova, Marina; Zhuravleva, Margarita; Miftakhova, Regina; Arkhipova, Svetlana; Evtugin, Vladimir; Khaiboullina, Sventlana; Kiyasov, Andrey; Persson, Jenny; Mongan, Nigel P.; Pestell, Richard; Rizvanov, Albert A.

Authors

Marina Gomzikova

Margarita Zhuravleva

Regina Miftakhova

Svetlana Arkhipova

Vladimir Evtugin

Sventlana Khaiboullina

Andrey Kiyasov

Jenny Persson

Richard Pestell

Albert A. Rizvanov



Abstract

Naturally occurring extracellular vesicles (EVs) play essential roles in intracellular communication and delivery of bioactive molecules. Therefore it has been suggested that EVs could be used for delivery of therapeutics. However, to date the therapeutic application of EVs has been limited by number of factors, including limited yield and full understanding of their biological activities. To address these issues, we analyzed the morphology, molecular composition, fusion capacity and biological activity of Cytochalasin B-induced membrane vesicles (CIMVs). The size of these vesicles was comparable to that of naturally occurring EVs. In addition, we have shown that CIMVs from human SH-SY5Y cells contain elevated levels of VEGF as compared to the parental cells, and stimulate angiogenesis in vitro and in vivo.

Journal Article Type Article
Publication Date Jul 31, 2017
Journal Oncotarget
Electronic ISSN 1949-2553
Publisher Impact Journals
Peer Reviewed Peer Reviewed
Volume 8
Issue 41
APA6 Citation Gomzikova, M., Zhuravleva, M., Miftakhova, R., Arkhipova, S., Evtugin, V., Khaiboullina, S., …Rizvanov, A. A. (2017). Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells. Oncotarget, 8(41), https://doi.org/10.18632/oncotarget.19723
DOI https://doi.org/10.18632/oncotarget.19723
Keywords extracellular vesicles, membrane vesicles, Cytochalasin B-induced membrane vesicles, angiogenesis, cell-free therapy
Publisher URL http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=19723&path[]=63002
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

Files

Oncotarget_2017.pdf (1.4 Mb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





You might also like



Downloadable Citations

;