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Detection and analysis of RNA methylation

Mongan, Nigel P.; Emes, Richard D.; Archer, Nathan


Professor of Bioinformatics


© 2019 Mongan NP et al. Our understanding of the expanded genetic alphabet has been growing rapidly over the last two decades, and many of these developments came more than 80 years after the original discovery of a modified guanine in tuberculosis DNA. These new understandings, leading to the field of epigenetics, have led to exciting new fundamental and applied knowledge and to the development of novel classes of drugs exploiting this new biology. The number of methyl modifications to RNA is about seven times greater than those found on DNA, and our ability to interrogate these enigmatic nucleobases has lagged significantly until recent years as an explosion in technologies and understanding has revealed the roles and regulation of RNA methylation in several fundamental and disease-associated biological processes. Here, we outline how the technology has evolved and which strategies are commonly used in the modern epitranscriptomics revolution and give a foundation in the understanding and application of the rich variety of these methods to novel biological questions.


Mongan, N. P., Emes, R. D., & Archer, N. (2019). Detection and analysis of RNA methylation. F1000Research, 8, 559.

Journal Article Type Article
Acceptance Date Mar 26, 2019
Online Publication Date Apr 26, 2019
Publication Date Apr 26, 2019
Deposit Date Jun 18, 2019
Publicly Available Date Jul 1, 2019
Journal F1000Research
Print ISSN 2046-1402
Electronic ISSN 1759-796X
Publisher F1000Research
Peer Reviewed Peer Reviewed
Volume 8
Pages 559
Public URL
Publisher URL


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