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Professor Roshan Nair's Outputs (156)

Mental health of people with multiple sclerosis during the COVID-19 outbreak: A prospective cohort and cross-sectional case–control study of the UK MS Register (2021)
Journal Article
Garjani, A., Hunter, R., Law, G. R., Middleton, R. M., Tuite-Dalton, K. A., Dobson, R., Ford, D. V., Hughes, S., Pearson, O. R., Rog, D., Tallantyre, E. C., Nicholas, R., Morriss, R., Evangelou, N., & das Nair, R. (2022). Mental health of people with multiple sclerosis during the COVID-19 outbreak: A prospective cohort and cross-sectional case–control study of the UK MS Register. Multiple Sclerosis Journal, 28(7), 1060-1071. https://doi.org/10.1177/13524585211020435

Background: People with MS (pwMS) have had higher rates of anxiety and depression than the general population before the COVID-19 pandemic, placing them at higher risk of experiencing poor psychological wellbeing during the pandemic. Objective: To as... Read More about Mental health of people with multiple sclerosis during the COVID-19 outbreak: A prospective cohort and cross-sectional case–control study of the UK MS Register.

COVID-19 is associated with new symptoms of multiple sclerosis that are prevented by disease modifying therapies (2021)
Journal Article
Garjani, A., Middleton, R. M., Hunter, R., Tuite-Dalton, K. A., Coles, A., Dobson, R., Duddy, M., Hughes, S., Pearson, O. R., Rog, D., Tallantyre, E. C., das Nair, R., Nicholas, R., & Evangelou, N. (2021). COVID-19 is associated with new symptoms of multiple sclerosis that are prevented by disease modifying therapies. Multiple Sclerosis and Related Disorders, 52, Article 102939. https://doi.org/10.1016/j.msard.2021.102939

Background

Infections can trigger exacerbations of multiple sclerosis (MS). The effects of the coronavirus disease 2019 (COVID-19) on MS are not known. The aim of this study was to understand the impact of COVID-19 on new and pre-existing symptoms... Read More about COVID-19 is associated with new symptoms of multiple sclerosis that are prevented by disease modifying therapies.

Cognitive assessment in multiple sclerosis clinical care: A qualitative evaluation of stakeholder perceptions and preferences (2021)
Journal Article
Elwick, H., Smith, L., Mhizha-Murira, J. R., Topcu, G., Leighton, P., Drummond, A., Evangelou, N., & Das Nair, R. (2022). Cognitive assessment in multiple sclerosis clinical care: A qualitative evaluation of stakeholder perceptions and preferences. Neuropsychological Rehabilitation, 32(7), 1456-1474. https://doi.org/10.1080/09602011.2021.1899942

There is a growing consensus that cognitive assessments should form part of routine clinical care in Multiple Sclerosis (MS). However, what remains unclear is which assessments are preferred by “stakeholders” (including people with MS, family members... Read More about Cognitive assessment in multiple sclerosis clinical care: A qualitative evaluation of stakeholder perceptions and preferences.

The Central Aspects of Pain in the Knee (CAP-Knee) questionnaire; a mixed-methods study of a self-report instrument for assessing central mechanisms in people with knee pain (2021)
Journal Article
Akin-Akinyosoye, K., James, R. J. E., Mcwilliams, D. F., Millar, B., Das Nair, R., Ferguson, E., & Walsh, D. A. (2021). The Central Aspects of Pain in the Knee (CAP-Knee) questionnaire; a mixed-methods study of a self-report instrument for assessing central mechanisms in people with knee pain. Osteoarthritis and Cartilage, 29(6), 802-814. https://doi.org/10.1016/j.joca.2021.02.562

OBJECTIVES: Pain is the prevailing symptom of knee osteoarthritis. Central sensitisation creates discordance between pain and joint pathology. We previously reported a central pain mechanisms trait derived from 8 discrete characteristics: neuropathic... Read More about The Central Aspects of Pain in the Knee (CAP-Knee) questionnaire; a mixed-methods study of a self-report instrument for assessing central mechanisms in people with knee pain.

Therapist competence and clinical outcome in the rehabilitation of memory following traumatic brain injury trial (2021)
Journal Article
Trigg, E., Clarke, S., Wong, D., & Nair, R. (2021). Therapist competence and clinical outcome in the rehabilitation of memory following traumatic brain injury trial. Brain Injury, 35(4), 395-403. https://doi.org/10.1080/02699052.2021.1877817

Objectives: Therapist competencies when delivering an intervention can impact clinical outcomes. However, the relationship between competence and outcome in the context of memory rehabilitation has not previously been investigated. We aimed to evalua... Read More about Therapist competence and clinical outcome in the rehabilitation of memory following traumatic brain injury trial.

Vocational rehabilitation to enhance return to work after trauma (ROWTATE): protocol for a non-randomised single-arm mixed-methods feasibility study (2021)
Journal Article
Kendrick, D., das Nair, R., Kellezi, B., Morriss, R., Kettlewell, J., Holmes, J., Timmons, S., Bridger, K., Patel, P., Brooks, A., Hoffman, K., & Radford, K. (2021). Vocational rehabilitation to enhance return to work after trauma (ROWTATE): protocol for a non-randomised single-arm mixed-methods feasibility study. Pilot and Feasibility Studies, 7(1), Article 29. https://doi.org/10.1186/s40814-021-00769-4

Background
Traumatic injuries are common amongst working age adults. Survivors often experience physical and psychological problems, reduced quality of life and difficulty returning to work. Vocational rehabilitation improves work outcomes for a ran... Read More about Vocational rehabilitation to enhance return to work after trauma (ROWTATE): protocol for a non-randomised single-arm mixed-methods feasibility study.

The evidence for cognitive behavioural therapy in any condition, population or context: a meta-review of systematic reviews and panoramic meta-analysis (2021)
Journal Article
Fordham, B., Sugavanam, T., Edwards, K., Stallard, P., Howard, R., Das Nair, R., Copsey, B., Lee, H., Howick, J., Hemming, K., & Lamb, S. E. (2021). The evidence for cognitive behavioural therapy in any condition, population or context: a meta-review of systematic reviews and panoramic meta-analysis. Psychological Medicine, 51(1), 21-29. https://doi.org/10.1017/s0033291720005292

The majority of psychological treatment research is dedicated to investigating the effectiveness of cognitive behavioural therapy (CBT) across different conditions, population and contexts. We aimed to summarise the current systematic review evidence... Read More about The evidence for cognitive behavioural therapy in any condition, population or context: a meta-review of systematic reviews and panoramic meta-analysis.

Dorsolateral prefrontal circuit effective connectivity mediates the relationship between white matter structure and PASAT‐3 performance in multiple sclerosis (2020)
Journal Article
Meng, D., Welton, T., Elsarraj, A., Morgan, P. S., das Nair, R., Constantinescu, C. S., Evangelou, N., Auer, D. P., & Dineen, R. A. (2020). Dorsolateral prefrontal circuit effective connectivity mediates the relationship between white matter structure and PASAT‐3 performance in multiple sclerosis. Human Brain Mapping, 42(2), 495-509. https://doi.org/10.1002/hbm.25239

Three decades ago a series of parallel circuits were described involving the frontal cortex and deep grey matter structures, with putative roles in control of motor and oculomotor function, cognition, behaviour and emotion. The circuit comprising the... Read More about Dorsolateral prefrontal circuit effective connectivity mediates the relationship between white matter structure and PASAT‐3 performance in multiple sclerosis.

Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners (2020)
Journal Article
Smith, L., Elwick, H., Mhizha-Murira, J., Topcu, G., Bale, C., Evangelou, N., Timmons, S., Leighton, P., & Das Nair, R. (2021). Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners. Multiple Sclerosis and Related Disorders, 49, Article 102563. https://doi.org/10.1016/j.msard.2020.102563

Background: Cognitive problems are a common and debilitating symptom of multiple sclerosis (MS). Screening and treatment for cognitive problems are recommended, however these are not routinely delivered in UK clinics.

We collected and synthesised... Read More about Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners.

Psychosocial adjustment to multiple sclerosis diagnosis: A meta-review of systematic reviews (2020)
Journal Article
Topcu, G., Griffiths, H., Bale, C., Trigg, E., Clarke, S., Potter, K.-J., Mhizha-Murira, J. R., Drummond, A., Evangelou, N., Fitzsimmons, D., & das Nair, R. (2020). Psychosocial adjustment to multiple sclerosis diagnosis: A meta-review of systematic reviews. Clinical Psychology Review, 82, Article 101923. https://doi.org/10.1016/j.cpr.2020.101923

This meta-review aimed to synthesise evidence on psychosocial adjustment to multiple sclerosis, to identify available treatment models and services for recently diagnosed individuals, and to explore their effectiveness. MEDLINE, CINAHL, EMBASE, PsycI... Read More about Psychosocial adjustment to multiple sclerosis diagnosis: A meta-review of systematic reviews.

The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol (2020)
Journal Article
Hall, M. C., Fuller, A., Nomikos, P. A., Millar, B., Ogollah, R., Valdes, A., Greenhaff, P., Das Nair, R., Doherty, M., Walsh, D. A., & Abhishek, A. (2020). The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol. BMJ Open, 10(9), Article e037760

Introduction: Knee pain and osteoarthritis (OA) are a common cause of disability. The UK National Institute of Health and Care Excellence (NICE) OA guidelines recommend education, exercise and weight-loss advice (if overweight) as core interventions... Read More about The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol.

East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol (2020)
Journal Article
Hall, M., Fuller, A., Nomikos, P. A., Millar, B., Ogollah, R., Valdes, A., Greenhaff, P., Das Nair, R., Doherty, M., Walsh, D. A., & Abhishek, A. (2020). East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol. BMJ Open, 10(9), Article e037760. https://doi.org/10.1136/bmjopen-2020-037760

© 2020 BMJ Open Introduction Knee pain due to osteoarthritis (OA) is a common cause of disability. The UK National Institute for Health and Care Excellence OA guidelines recommend education, exercise and weight loss advice (if overweight) as core int... Read More about East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol.

Self-diagnosed COVID-19 in people with multiple sclerosis: a community-based cohort of the UK MS Register (2020)
Journal Article
Evangelou, N., Garjani, A., Das Nair, R., Hunter, R., Tuite-Dalton, K., Craig, E., Rodgers, W., Coles, A., Dobson, R., Duddy, M., Ford, D., Hughes, S., Pearson, O., Middleton, L., Rog, D., Tallantyre, E., Friede, T., Middleton, R., & Nicholas, R. (2021). Self-diagnosed COVID-19 in people with multiple sclerosis: a community-based cohort of the UK MS Register. Journal of Neurology, Neurosurgery and Psychiatry, 92(1), 107-109. https://doi.org/10.1136/jnnp-2020-324449

Protocol for the process evaluation of the Promoting Activity, Independence and stability in early Dementia (PrAISED), following changes required by the COVID-19 pandemic (2020)
Journal Article
Di Lorito, C., Bosco, A., Goldberg, S., das Nair, R., O'Brien, R., Howe, L., van der Wardt, V., Pollock, K., Booth, V., Logan, P., Godfrey, M., Dunlop, M., Horne, J., & Harwood, R. (2020). Protocol for the process evaluation of the Promoting Activity, Independence and stability in early Dementia (PrAISED), following changes required by the COVID-19 pandemic. BMJ Open, 10(8), https://doi.org/10.1136/bmjopen-2020-039305

Introduction. The PrAISED Randomised Controlled Trial (RCT) is evaluating a home-based, face-to-face, individually tailored, activity and exercise programme for people living with dementia. Social distancing requirements following the COVID-19 pandem... Read More about Protocol for the process evaluation of the Promoting Activity, Independence and stability in early Dementia (PrAISED), following changes required by the COVID-19 pandemic.

The factor structure of the Center for Epidemiological Study - Depression Scale in people with multiple sclerosis (2020)
Journal Article
Kneebone, I. I., Fife-Schaw, C., Lam, L. T., & das Nair, R. (2020). The factor structure of the Center for Epidemiological Study - Depression Scale in people with multiple sclerosis. F1000Research, 9, Article 1038. https://doi.org/10.12688/f1000research.25129.1

Background: Depression is common in multiple sclerosis (MS); however, its assessment is complicated by biological processes. In this context it is important to consider the performance of depression screening measures including that their factor stru... Read More about The factor structure of the Center for Epidemiological Study - Depression Scale in people with multiple sclerosis.

Developing a Fatigue Programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2) (2020)
Journal Article
Drummond, A., Ablewhite, J., Condon, L., das Nair, R., Jones, A., Jones, F., Sprigg, N., & Thomas, S. (2020). Developing a Fatigue Programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2). British Journal of Occupational Therapy, 83(11), 674-679. https://doi.org/10.1177/0308022620944797

Introduction

Post-stroke fatigue is common and is one of the most distressing symptoms after stroke. It has a negative impact on physical, social and psychological functioning; it is also associated with poor outcomes and increased mortality. The... Read More about Developing a Fatigue Programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2).

Developing a fatigue programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2) study (2020)
Journal Article
Drummond, A., Ablewhite, J., Condon, L., Nair, R. D., Jones, A., Jones, F., Sprigg, N., & Thomas, S. (2020). Developing a fatigue programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2) study. British Journal of Occupational Therapy, 83(11), 674-679. https://doi.org/10.1177/0308022620944797

Introduction: Post-stroke fatigue (PSF) is common and is one of the most distressing symptoms after stroke. It has a negative impact on physical, social and psychological functioning: it is also associated with poor outcomes and increased mortality.... Read More about Developing a fatigue programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2) study.

Results of a UK-wide vignette study with occupational therapists to explore cognitive screening post-stroke (2020)
Journal Article
Geraghty, J., Ablewhite, J., das Nair, R., Lincoln, N., Kontou, E., Roffe, J., Lannin, N., & Drummond, A. (2020). Results of a UK-wide vignette study with occupational therapists to explore cognitive screening post-stroke. International Journal of Therapy and Rehabilitation, 27(7),

Background.
There is a paucity of evidence in the UK regarding occupational therapy (OT) cognitive screening, and whether, and how, cognitive impairments are identified and assessed.

Aims
To identify current OT practice for the assessment of c... Read More about Results of a UK-wide vignette study with occupational therapists to explore cognitive screening post-stroke.

Post-stroke fatigue: a scoping review (2020)
Journal Article
Aali, G., Drummond, A., das Nair, R., & Shokraneh, F. (2020). Post-stroke fatigue: a scoping review. F1000Research, 9, Article 242. https://doi.org/10.12688/f1000research.22880.1

Background: Post-stroke fatigue (PSF) is one of the most common and frustrating outcomes of stroke. It has a high prevalence and it can persist for many years after stroke. PSF itself contributes to a wider range of undesirable outcomes that affect a... Read More about Post-stroke fatigue: a scoping review.