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Professor Dorothee Auer's Outputs (66)

Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis (2018)
Journal Article
Cottam, W. J., Iwabuchi, S. J., Drabek, M. M., Reckziegel, D., & Auer, D. P. (2018). Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis. PAIN, 159(5), https://doi.org/10.1097/j.pain.0000000000001209

Resting-state functional connectivity (FC) has proven a powerful approach to understand the neural underpinnings of chronic pain, reporting altered connectivity in three main networks: the default mode (DMN), central executive (CEN), and the salience... Read More about Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis.

Patterns of grey matter loss associated with motor subscores in early Parkinson's disease (2017)
Journal Article
Li, X., Xing, Y., Martin-Bastida, A., Piccini, P., & Auer, D. P. (in press). Patterns of grey matter loss associated with motor subscores in early Parkinson's disease. NeuroImage: Clinical, 17, https://doi.org/10.1016/j.nicl.2017.11.009

Classical motor symptoms of Parkinson's disease (PD) such as tremor, rigidity, bradykinesia, and axial symptoms are graded in the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III. It is yet to be ascertained whether... Read More about Patterns of grey matter loss associated with motor subscores in early Parkinson's disease.

Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome (2017)
Journal Article
Reckziegel, D., Bailey, H., Cottam, W. J., Tench, C. R., Mahajan, R. P., Walsh, D. A., Knaggs, R., & Auer, D. P. (in press). Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome. BMJ Open, 7(6), Article e014013. https://doi.org/10.1136/bmjopen-2016-014013

Introduction: Osteoarthritis (OA) pain is a major cause of long-term disability and chronic pain in the adult population. One in five patients does not receive satisfactory pain relief, which reflects the complexity of chronic pain and the current la... Read More about Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome.

Manganese-enhanced magnetic resonance imaging depicts brain activity in models of acute and chronic pain: a new window to study experimental spontaneous pain? (2017)
Journal Article
Devonshire, I. M., Burston, J., Xu, L., Lillywhite, A., Prior, M., Watson, D. J., Greenspon, C., Iwabuchi, S. J., Auer, D. P., & Chapman, V. (2017). Manganese-enhanced magnetic resonance imaging depicts brain activity in models of acute and chronic pain: a new window to study experimental spontaneous pain?. NeuroImage, 157, https://doi.org/10.1016/j.neuroimage.2017.06.034

Application of functional imaging techniques to animal models is vital to understand pain mechanisms, but is often confounded by the need to limit movement artefacts with anaesthesia, and a focus on evoked responses rather than clinically relevant sp... Read More about Manganese-enhanced magnetic resonance imaging depicts brain activity in models of acute and chronic pain: a new window to study experimental spontaneous pain?.

Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER (2017)
Journal Article
Chen, C., Sigurdsson, H. P., Pépés, S. E., Auer, D. P., Morris, P. G., Morgan, P. S., Gowland, P. A., & Jackson, S. R. (2017). Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER. NeuroImage, 156, 207-213. https://doi.org/10.1016/j.neuroimage.2017.05.044

Functional magnetic resonance spectroscopy (fMRS) has been used to assess the dynamic metabolic responses of the brain to a physiological stimulus non-invasively. However, only limited information on the dynamic functional response of γ-aminobutyric... Read More about Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER.

Limbic grey matter changes in early Parkinson's disease (2017)
Journal Article
Li, X., Xing, Y., Schwarz, S. T., & Auer, D. P. (in press). Limbic grey matter changes in early Parkinson's disease. Human Brain Mapping, https://doi.org/10.1002/hbm.23610

The purpose of this study was to investigate local and network related changes of limbic grey matter in early Parkinson’s disease (PD) and their interrelation with non-motor symptom severity. We applied voxel-based morphometric methods in 538 T1 MRI... Read More about Limbic grey matter changes in early Parkinson's disease.

Magnetic resonance imaging plaque hemorrhage for risk stratification in carotid artery disease with moderate risk under current medical therapy (2017)
Journal Article
Hosseini, A. A., Simpson, R. J., Altaf, N., Bath, P. M., MacSweeney, S. T., & Auer, D. P. (2017). Magnetic resonance imaging plaque hemorrhage for risk stratification in carotid artery disease with moderate risk under current medical therapy. Stroke, 48(3), https://doi.org/10.1161/STROKEAHA.116.015504

Background and Purpose—Magnetic resonance imaging (MRI)–defined carotid plaque hemorrhage (MRIPH) can predict recurrent cerebrovascular ischemic events in severe symptomatic carotid stenosis. It is less clear whether MRIPH can improve risk stratifica... Read More about Magnetic resonance imaging plaque hemorrhage for risk stratification in carotid artery disease with moderate risk under current medical therapy.

In Vivo Assessment of Brainstem Depigmentation in Parkinson Disease: Potential as a Severity Marker for Multicenter Studies (2016)
Journal Article
Schwarz, S. T., Xing, Y., Tomar, P., Bajaj, N., & Auer, D. P. (2017). In Vivo Assessment of Brainstem Depigmentation in Parkinson Disease: Potential as a Severity Marker for Multicenter Studies. Radiology, 283(3), 789-798. https://doi.org/10.1148/radiol.2016160662

Purpose:
To investigate the pattern of neuromelanin signal intensity loss within the substantia nigra pars compacta (SNpc), locus coeruleus, and ventral tegmental area in Parkinson disease (PD); the specific aims were (a) to study regional magnetic... Read More about In Vivo Assessment of Brainstem Depigmentation in Parkinson Disease: Potential as a Severity Marker for Multicenter Studies.

Probe-Specific Procedure to Estimate Sensitivity and Detection Limits for 19F Magnetic Resonance Imaging (2016)
Journal Article
Faas, H., Taylor, A. J., Granwehr, J., Lesbats, C., Krupa, J. L., Six, J. S., Pavlovskaya, G. E., Thomas, N. R., Auer, D. P., & Meersmann, T. (2016). Probe-Specific Procedure to Estimate Sensitivity and Detection Limits for 19F Magnetic Resonance Imaging. PLoS ONE, 11(10), e0163704. https://doi.org/10.1371/journal.pone.0163704

© 2016 Taylor et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cre... Read More about Probe-Specific Procedure to Estimate Sensitivity and Detection Limits for 19F Magnetic Resonance Imaging.

Cerebral cortical thickness in chronic pain due to knee osteoarthritis: the effect of pain duration and pain densitization (2016)
Journal Article
Alshuft, H., Condon, L., Dineen, R. A., & Auer, D. P. (in press). Cerebral cortical thickness in chronic pain due to knee osteoarthritis: the effect of pain duration and pain densitization. PLoS ONE, 11(9), Article e0161687. https://doi.org/10.1371/journal.pone.0161687

Objective

This study investigates associations between cortical thickness and pain duration, and central sensitization as markers of pain progression in painful knee osteoarthritis.

Methods

Whole brain cortical thickness and pressure pain th... Read More about Cerebral cortical thickness in chronic pain due to knee osteoarthritis: the effect of pain duration and pain densitization.

Lesion topography and microscopic white matter tract damage contribute to cognitive impairment in symptomatic carotid artery disease (2016)
Journal Article
Meng, D., Hosseini, A. A., Simpson, R. J., Shaikh, Q., Tench, C. R., Dineen, R. A., & Auer, D. P. (2017). Lesion topography and microscopic white matter tract damage contribute to cognitive impairment in symptomatic carotid artery disease. Radiology, 282(2), 502-515. https://doi.org/10.1148/radiol.2016152685

Purpose: To investigate associations between neuroimaging markers of cerebrovascular disease, including lesion topography and extent and severity of strategic and global cerebral tissue injury, and cognition in carotid artery disease (CAD).
Material... Read More about Lesion topography and microscopic white matter tract damage contribute to cognitive impairment in symptomatic carotid artery disease.

Novel Methods for Microglia Segmentation, Feature Extraction, and Classification (2016)
Journal Article
Ding, Y., Pardon, M. C., Agostini, A., Faas, H., Duan, J., Ward, W. O., Easton, F., Auer, D. P., & Bai, L. (2016). Novel Methods for Microglia Segmentation, Feature Extraction, and Classification. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 14(6), 1366-1377. https://doi.org/10.1109/TCBB.2016.2591520

© 2017 IEEE. Segmentation and analysis of histological images provides a valuable tool to gain insight into the biology and function of microglial cells in health and disease. Common image segmentation methods are not suitable for inhomogeneous histo... Read More about Novel Methods for Microglia Segmentation, Feature Extraction, and Classification.

Functional reorganisation in chronic pain and neural correlates of pain sensitisation (2016)
Journal Article
Tanasescu, R., Cottam, W., Condon, L., Tench, C. R., & Auer, D. P. (2016). Functional reorganisation in chronic pain and neural correlates of pain sensitisation. Neuroscience and Biobehavioral Reviews, 68, 120-133. https://doi.org/10.1016/j.neubiorev.2016.04.001

© 2016 Published by Elsevier Ltd. Maladaptive mechanisms of pain processing in chronic pain conditions (CP) are poorly understood. We used coordinate based meta-analysis of 266 fMRI pain studies to study functional brain reorganisation in CP and expe... Read More about Functional reorganisation in chronic pain and neural correlates of pain sensitisation.

Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain (2016)
Journal Article
Abaei, M., Sagar, D. R., Stockley, E. G., Spicer, C. H., Prior, M., Chapman, V., & Auer, D. P. (in press). Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain. Molecular Pain, 12, https://doi.org/10.1177/1744806916642445

Background: The mechanisms driving osteoarthritic pain remain poorly understood, but there is increasing evidence for a role of the central nervous system in the chronification of pain.We used functional magnetic resonance imaging to investigate the... Read More about Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain.

Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer's disease models (2016)
Journal Article
Pardon, M.-C., Yanez Lopez, M., Yuchun, D., Bai, L., Marjańska, M., Brignell, C., Prior, M., Brignell, C., Parhizkar, S., Agostini, A., Auer, D. P., & Faas, H. M. (2016). Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer's disease models. Scientific Reports, 6, 1-12. https://doi.org/10.1038/srep19880

Functionally Relevant White Matter Degradation in Multiple Sclerosis: A Tract-based Spatial Meta-Analysis (2014)
Journal Article
Welton, T., Kent, D., Constantinescu, C. S., Auer, D. P., & Dineen, R. A. (2015). Functionally Relevant White Matter Degradation in Multiple Sclerosis: A Tract-based Spatial Meta-Analysis. Radiology, 275(1), 89-96. https://doi.org/10.1148/radiol.14140925

Purpose

To identify statistical consensus between published studies for distribution and functional relevance of tract white matter (WM) degradation in multiple sclerosis (MS).
Materials and Methods

By systematically searching online databases... Read More about Functionally Relevant White Matter Degradation in Multiple Sclerosis: A Tract-based Spatial Meta-Analysis.