Lesion topography and microscopic white matter tract damage contribute to cognitive impairment in symptomatic carotid artery disease

Meng, Dewen; Hosseini, Akram A.; Simpson, Richard J.; Shaikh, Quratulain; Tench, Christopher R.; Dineen, Robert A.; Auer, Dorothee P.

Abstract

Purpose: To investigate associations between neuroimaging markers of cerebrovascular disease, including lesion topography and extent and severity of strategic and global cerebral tissue injury, and cognition in carotid artery disease (CAD).
Materials and Methods: All participants gave written informed consent to undergo brain magnetic resonance imaging and the Addenbrooke’s Cognitive Examination–Revised. One hundred eight patients with symptomatic CAD but no dementia were included, and a score less than 82 represented cognitive impairment. Group comparison and interrelations between global cognitive and fluency performance, lesion topography, and ultrastructural damage were assessed with voxel-based statistics. Associations between cognition, medial temporal lobe atrophy (MTA), lesion volumes, and global white matter ultrastructural damage indexed as increased mean diffusivity were tested with regression analysis by controlling for age. Diagnostic accuracy of imaging markers selected from a multivariate prediction model was tested with receiver operating characteristic analysis.
Results: Cognitively impaired patients (n = 53 [49.1%], classified as having probable vascular cognitive disorder) were older than nonimpaired patients (P = .027) and had more frequent MTA (P

Citation

Meng, D., Hosseini, A. A., Simpson, R. J., Shaikh, Q., Tench, C. R., Dineen, R. A., & Auer, D. P. (2017). Lesion topography and microscopic white matter tract damage contribute to cognitive impairment in symptomatic carotid artery disease. Radiology, 282(2), 502-515. https://doi.org/10.1148/radiol.2016152685

• Journal Article Type: Article
• Acceptance Date: Jun 3, 2016
• Online Publication Date: Sep 16, 2016
• Publication Date: 2017-02
• Deposit Date: Nov 8, 2016
• Publicly Available Date: Mar 30, 2020
• Journal: Radiology
• Print ISSN: 0033-8419
• Electronic ISSN: 1527-1315
• Publisher: Radiological Society of North America
• Peer Reviewed: Peer Reviewed
• Volume: 282
• Issue: 2
• Pages: 502-515
• DOI: https://doi.org/10.1148/radiol.2016152685
• Public URL: https://nottingham-repository.worktribe.com/output/843646
• Publisher URL: http://pubs.rsna.org/doi/10.1148/radiol.2016152685