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Lesion topography and microscopic white matter tract damage contribute to cognitive impairment in symptomatic carotid artery disease

Meng, Dewen; Hosseini, Akram A.; Simpson, Richard J.; Shaikh, Quratulain; Tench, Christopher R.; Dineen, Robert A.; Auer, Dorothee P.

Authors

Dewen Meng

Akram A. Hosseini

Richard J. Simpson

Quratulain Shaikh

Christopher R. Tench

Robert A. Dineen

Dorothee P. Auer

Abstract

Purpose: To investigate associations between neuroimaging markers of cerebrovascular disease, including lesion topography and extent and severity of strategic and global cerebral tissue injury, and cognition in carotid artery disease (CAD).
Materials and Methods: All participants gave written informed consent to undergo brain magnetic resonance imaging and the Addenbrooke’s Cognitive Examination–Revised. One hundred eight patients with symptomatic CAD but no dementia were included, and a score less than 82 represented cognitive impairment. Group comparison and interrelations between global cognitive and fluency performance, lesion topography, and ultrastructural damage were assessed with voxel-based statistics. Associations between cognition, medial temporal lobe atrophy (MTA), lesion volumes, and global white matter ultrastructural damage indexed as increased mean diffusivity were tested with regression analysis by controlling for age. Diagnostic accuracy of imaging markers selected from a multivariate prediction model was tested with receiver operating characteristic analysis.
Results: Cognitively impaired patients (n = 53 [49.1%], classified as having probable vascular cognitive disorder) were older than nonimpaired patients (P = .027) and had more frequent MTA (P

Journal Article Type Article
Publication Date 2017-02
Journal Radiology
Print ISSN 0033-8419
Electronic ISSN 1527-1315
Publisher Radiological Society of North America
Peer Reviewed Peer Reviewed
Volume 282
Issue 2
Pages 502-515
Institution Citation Meng, D., Hosseini, A. A., Simpson, R. J., Shaikh, Q., Tench, C. R., Dineen, R. A., & Auer, D. P. (2017). Lesion topography and microscopic white matter tract damage contribute to cognitive impairment in symptomatic carotid artery disease. Radiology, 282(2), 502-515. https://doi.org/10.1148/radiol.2016152685
DOI https://doi.org/10.1148/radiol.2016152685
Publisher URL http://pubs.rsna.org/doi/10.1148/radiol.2016152685
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0




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