Skip to main content

Research Repository

See what's under the surface

Advanced Search

Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER

Chen, Chen; Sigurdsson, Hilmar P.; Pépés, Sophia E.; Auer, Dorothee P.; Morris, Peter G.; Morgan, Paul S.; Gowland, Penny A.; Jackson, Stephen R.

Authors

Chen Chen

Hilmar P. Sigurdsson

Sophia E. Pépés

Dorothee P. Auer

Peter G. Morris

Paul S. Morgan

Penny A. Gowland

Stephen R. Jackson



Abstract

Functional magnetic resonance spectroscopy (fMRS) has been used to assess the dynamic metabolic responses of the brain to a physiological stimulus non-invasively. However, only limited information on the dynamic functional response of γ-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain, is available. We aimed to measure the activation-induced changes in GABA unambiguously using a spectral editing method, instead of the conventional direct detection techniques used in previous fMRS studies. The Mescher-Garwood-semi-localised by adiabatic selective refocusing (MEGA-sLASER) sequence was developed at 7 T to obtain the time course of GABA concentration without macromolecular contamination. A significant decrease (−12±5%) in the GABA to total creatine ratio (GABA/tCr) was observed in the motor cortex during a period of 10 minutes of hand-clenching, compared to an initial baseline level (GABA/tCr = 0.11±0.02) at rest. An increase in the Glx (glutamate and glutamine) to tCr ratio was also found, which is in agreement with previous findings. In contrast, no significant changes in NAA/tCr and tCr were detected. With consistent and highly efficient editing performance for GABA detection and the advantage of visually identifying GABA resonances in the spectra, MEGA-sLASER is demonstrated to be an effective method for studying of dynamic changes in GABA at 7 T.

Journal Article Type Article
Publication Date 2017-08
Journal NeuroImage
Print ISSN 1053-8119
Electronic ISSN 1095-9572
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 156
Pages 207-213
APA6 Citation Chen, C., Sigurdsson, H. P., Pépés, S. E., Auer, D. P., Morris, P. G., Morgan, P. S., …Jackson, S. R. (2017). Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER. NeuroImage, 156, 207-213. https://doi.org/10.1016/j.neuroimage.2017.05.044
DOI https://doi.org/10.1016/j.neuroimage.2017.05.044
Keywords GABA; MEGA editing; functional MRS; motor cortex; 7T
Publisher URL http://www.sciencedirect.com/science/article/pii/S1053811917304433
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0
Additional Information This article is maintained by: Elsevier; Article Title: Activation induced changes in GABA: Functional MRS at 7T with MEGA-sLASER; Journal Title: NeuroImage; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.neuroimage.2017.05.044; Content Type: article; Copyright: © 2017 Elsevier Inc. All rights reserved.

Files

Chen et al submitted and accepted.pdf (531 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





You might also like



Downloadable Citations

;