Oxygen-enhanced MRI assessment of tumour hypoxia in head and neck cancer is feasible and well tolerated in the clinical setting

McCabe, Alastair; Martin, Stewart; Rowe, Selene; Shah, Jagrit; Morgan, Paul S.; Borys, Damian; Panek, Rafal

Abstract

Background: Tumour hypoxia is a recognised cause of radiotherapy treatment resistance in head and neck squamous cell carcinoma (HNSCC). Current positron emission tomography-based hypoxia imaging techniques are not routinely available in many centres. We investigated if an alternative technique called oxygen-enhanced magnetic resonance imaging (OE-MRI) could be performed in HNSCC. Methods: A volumetric OE-MRI protocol for dynamic T1 relaxation time mapping was implemented on 1.5-T clinical scanners. Participants were scanned breathing room air and during high-flow oxygen administration. Oxygen-induced changes in T1 times (ΔT1) and R2* rates (ΔR2*) were measured in malignant tissue and healthy organs. Unequal variance t-test was used. Patients were surveyed on their experience of the OE-MRI protocol. Results: Fifteen patients with HNSCC (median age 59years, range 38 to 76) and 10 non-HNSCC subjects (median age 46.5years, range 32 to 62) were scanned; the OE-MRI acquisition took less than 10min and was well tolerated. Fifteen histologically confirmed primary tumours and 41 malignant nodal masses were identified. Median (range) of ΔT1 times and hypoxic fraction estimates for primary tumours were -3.5% (-7.0 to -0.3%) and 30.7% (6.5 to 78.6%) respectively. Radiotherapy-responsive and radiotherapy-resistant primary tumours had mean estimated hypoxic fractions of 36.8% (95% confidence interval [CI] 17.4 to 56.2%) and 59.0% (95% CI 44.6 to 73.3%), respectively (p = 0.111). Conclusions: We present a well-tolerated implementation of dynamic, volumetric OE-MRI of the head and neck region allowing discernment of differing oxygen responses within biopsy-confirmed HNSCC. Trial registration: ClinicalTrials.gov, NCT04724096. Registered on 26 January 2021. Relevance statement: MRI of tumour hypoxia in head and neck cancer using routine clinical equipment is feasible and well tolerated and allows estimates of tumour hypoxic fractions in less than ten minutes. Key points: • Oxygen-enhanced MRI (OE-MRI) can estimate tumour hypoxic fractions in ten-minute scanning. • OE-MRI may be incorporable into routine clinical tumour imaging. • OE-MRI has the potential to predict outcomes after radiotherapy treatment. Graphical Abstract: (Figure presented.)

Citation

McCabe, A., Martin, S., Rowe, S., Shah, J., Morgan, P. S., Borys, D., & Panek, R. (2024). Oxygen-enhanced MRI assessment of tumour hypoxia in head and neck cancer is feasible and well tolerated in the clinical setting. European Radiology Experimental, 8(1), Article 27. https://doi.org/10.1186/s41747-024-00429-1

• Journal Article Type: Article
• Acceptance Date: Jan 8, 2024
• Online Publication Date: Mar 6, 2024
• Publication Date: Mar 6, 2024
• Deposit Date: Mar 25, 2024
• Publicly Available Date: Mar 26, 2024
• Journal: European Radiology Experimental
• Electronic ISSN: 2509-9280
• Publisher: SpringerOpen
• Peer Reviewed: Peer Reviewed
• Volume: 8
• Issue: 1
• Article Number: 27
• DOI: https://doi.org/10.1186/s41747-024-00429-1
• Keywords: Magnetic resonance imaging, Head and neck neoplasms, Oxygen, Tumour hypoxia, Radiotherapy
• Public URL: https://nottingham-repository.worktribe.com/output/32451000
• Publisher URL: https://eurradiolexp.springeropen.com/articles/10.1186/s41747-024-00429-1
• Additional Information: Received: 1 September 2023; Accepted: 8 January 2024; First Online: 6 March 2024; : ; : Ethical approval for this study was obtained from the South Central Berkshire Research Ethics Committee (reference 21/SC/0050) on 9 February 2021. Written informed consent was obtained from all subjects in this study.; : Not applicable.; : The authors declare no relationships with any companies, whose products or services may be related to the subject matter of the article.