All Outputs (151)

Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization (2022)
Journal Article
Shur, N. F., Simpson, E. J., Crossland, H., Chivaka, P. K., Constantin, D., Cordon, S. M., …Greenhaff, P. L. (2022). Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization. Journal of Cachexia, Sarcopenia and Muscle, 13(6), 2999-3013. https://doi.org/10.1002/jcsm.13075

Background: Bed rest (BR) reduces whole-body insulin-stimulated glucose disposal (GD) and alters muscle fuel metabolism, but little is known about metabolic adaptation from acute to chronic BR nor the mechanisms involved, particularly when volunteers... Read More about Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization.

A pen in the liver (2022)
Journal Article
Barrie, J., & Lobo, D. N. (2022). A pen in the liver. Radiology Case Reports, 17(10), 3992-3995. https://doi.org/10.1016/j.radcr.2022.07.096

A 24-year-old woman with anxiety, depression, and emotionally unstable personality disorder was referred to a tertiary center 2 weeks after ingesting multiple foreign bodies. She had undergone a laparoscopic cholecystectomy and a laparotomy for extra... Read More about A pen in the liver.

Randomised clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis (2022)
Journal Article
Herrod, P. J. J., Kwok, A. T., & Lobo, D. N. (2022). Randomised clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis. BJS Open, 6(4), Article zrac100

Background This aim of this study was to provide an updated meta-analysis comparing antibiotic therapy with appendicectomy in adults (16 years or older) with uncomplicated acute appendicitis. Methods A search for randomized clinical trials compa... Read More about Randomised clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis.

Digital Follow-Up After Elective Laparoscopic Cholecystectomy: A Feasibility Study (2022)
Journal Article
Daliya, P., Carvell, J., Rozentals, J., Lobo, D. N., & Parsons, S. L. (2022). Digital Follow-Up After Elective Laparoscopic Cholecystectomy: A Feasibility Study. World Journal of Surgery, 46, 2648-2658. https://doi.org/10.1007/s00268-022-06684-w

Background: Although recommendations exist for patients to be offered a post-operative helpline or telephone follow-up appointment at discharge after cholecystectomy, implementation of these is resource-intensive. Whilst the benefits of telephone fol... Read More about Digital Follow-Up After Elective Laparoscopic Cholecystectomy: A Feasibility Study.

O038 Digital consent: modernising data-sharing in surgery and empowering patients (2022)
Journal Article
Daliya, P., Lobo, D., & Parsons, S. (2022). O038 Digital consent: modernising data-sharing in surgery and empowering patients. British Journal of Surgery, 109(Supplement_4), Article znac242.038. https://doi.org/10.1093/bjs/znac242.038

Introduction Despite the 2015 Montgomery Ruling highlighting key requisites for informed consent, little has changed to modernise data-sharing and documentation of the consent process. Although many practitioners provide supplementary information to... Read More about O038 Digital consent: modernising data-sharing in surgery and empowering patients.

The need to improve opioid prescribing and data collection in patients undergoing orthopaedic surgery (2022)
Journal Article
Levy, N., McNally, S. A., & Lobo, D. N. (2022). The need to improve opioid prescribing and data collection in patients undergoing orthopaedic surgery. Anaesthesia, https://doi.org/10.1111/anae.15784

Utilising Electronic PROMs to Measure a Change in Health Following Elective Laparoscopic Cholecystectomy: A Feasibility Study (2022)
Journal Article
Daliya, P., Lobo, D. N., & Parsons, S. L. (2022). Utilising Electronic PROMs to Measure a Change in Health Following Elective Laparoscopic Cholecystectomy: A Feasibility Study. World Journal of Surgery, https://doi.org/10.1007/s00268-022-06588-9

Background The collection of patient-reported outcome measures (PROMs) has many benefits for clinical practice. However, there are many barriers that prevent them from becoming a part of routine clinical care. The aim of this feasibility study was t... Read More about Utilising Electronic PROMs to Measure a Change in Health Following Elective Laparoscopic Cholecystectomy: A Feasibility Study.

Unresolved issues in perioperative nutrition: A narrative review (2022)
Journal Article
Ford, K. L., Prado, C. M., Weimann, A., Schuetz, P., & Lobo, D. N. (2022). Unresolved issues in perioperative nutrition: A narrative review. Clinical Nutrition, 41(7), 1578-1590. https://doi.org/10.1016/j.clnu.2022.05.015

Surgical patients are at an increased risk of negative outcomes if they are malnourished or at risk of malnutrition preoperatively. Optimisation of nutritional status should be a focus throughout the perioperative continuum to promote improved surgic... Read More about Unresolved issues in perioperative nutrition: A narrative review.

Prospective validation of five malnutrition screening and assessment instruments among medical inpatients: Secondary analysis of a randomized clinical trial (2022)
Journal Article
Stalder, L., Kaegi-Braun, N., Gressies, C., Gregoriano, C., Tribolet, P., Lobo, D. N., …Schuetz, P. (2022). Prospective validation of five malnutrition screening and assessment instruments among medical inpatients: Secondary analysis of a randomized clinical trial. Clinical Nutrition, 41(6), 1307-1315. https://doi.org/10.1016/j.clnu.2022.04.025

Background & aims: Screening for malnutrition upon hospital admission is the first crucial step for proper nutritional assessment and treatment. While several nutritional screening and assessment instruments exist, there is a lack of head-to-head val... Read More about Prospective validation of five malnutrition screening and assessment instruments among medical inpatients: Secondary analysis of a randomized clinical trial.

Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong (2022)
Journal Article
Crush, J., Levy, N., Knaggs, R. D., & Lobo, D. N. (2022). Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong. British Journal of Anaesthesia, 129(2), 137-142. https://doi.org/10.1016/j.bja.2022.03.004

Opioids have a vital role in alleviating pain from cancer and surgery. Despite good intentions, it is now recognised that the original WHO Cancer Pain Relief guidance from 1986, in which opioids were classified as either weak or strong, has been both... Read More about Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong.

Early Postoperative Supplementary Parenteral Nutrition (2022)
Journal Article
Ljungqvist, O., Gustafsson, U. O., & Lobo, D. N. (2022). Early Postoperative Supplementary Parenteral Nutrition. JAMA Surgery, 209, Article 118333. https://doi.org/10.1001/jamasurg.2022.0266

Molten salts have been used in solar thermal energy storage due to their high energy storage density, low cost and excellent chemical stability. However, their application is limited by “bad days” such as cloudy days and winter because the weak conce... Read More about Early Postoperative Supplementary Parenteral Nutrition.

System-level policies on appropriate opioid use, a multi-stakeholder consensus (2022)
Journal Article
Forget, P., Patullo, C., Hill, D., Ambekar, A., Baldacchino, A., Cata, J., …Gilbert, S. (2022). System-level policies on appropriate opioid use, a multi-stakeholder consensus. BMC Health Services Research, 22(1), Article 329. https://doi.org/10.1186/s12913-022-07696-x

Background: This consensus statement was developed because there are concerns about the appropriate use of opioids for acute pain management, with opposing views in the literature. Consensus statement on policies for system-level interventions may he... Read More about System-level policies on appropriate opioid use, a multi-stakeholder consensus.

Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis (2022)
Journal Article
Althubeati, S., Avery, A., Tench, C., Lobo, D. N., Salter, A., & Eldeghaidy, S. (2022). Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis. Neuroscience and Biobehavioral Reviews, 136, Article 104603. https://doi.org/10.1016/j.neubiorev.2022.104603

Understanding how neurohormonal gut-brain signaling regulates appetite and satiety is vital for the development of therapies for obesity and altered eating behavior. However, reported brain areas associated with appetite or satiety regulators show in... Read More about Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis.

Validation of modified GLIM criteria to predict adverse clinical outcome and response to nutritional treatment: A secondary analysis of a randomized clinical trial (2022)
Journal Article
Kaegi-Braun, N., Boesiger, F., Tribolet, P., Gomes, F., Kutz, A., Hoess, C., …Schuetz, P. (2022). Validation of modified GLIM criteria to predict adverse clinical outcome and response to nutritional treatment: A secondary analysis of a randomized clinical trial. Clinical Nutrition, 41(4), 795-804. https://doi.org/10.1016/j.clnu.2022.02.009

Background & aims: The Global Leadership Initiative on Malnutrition (GLIM) recently suggested specific criteria to standardize the diagnosis of malnutrition. There is need for validation of these criteria regarding response to nutrition treatment. Ou... Read More about Validation of modified GLIM criteria to predict adverse clinical outcome and response to nutritional treatment: A secondary analysis of a randomized clinical trial.

Admission serum albumin concentrations and response to nutritional therapy in hospitalised patients at malnutrition risk: Secondary analysis of a randomised clinical trial (2022)
Journal Article
Bretschera, C., Boesiger, F., Kaegi-Braun, N., Hersberger, L., Lobo, D. N., Evans, D. C., …Schuetz, P. (2022). Admission serum albumin concentrations and response to nutritional therapy in hospitalised patients at malnutrition risk: Secondary analysis of a randomised clinical trial. EClinicalMedicine, 45, Article 101301. https://doi.org/10.1016/j.eclinm.2022.101301

Background Historically, admission serum albumin concentrations have been considered useful biochemical markers for nutrition assessment. However, there is a lack of randomised trial data investigating whether low albumin concentrations are helpful... Read More about Admission serum albumin concentrations and response to nutritional therapy in hospitalised patients at malnutrition risk: Secondary analysis of a randomised clinical trial.

The effects of elective abdominal surgery on protein turnover: A meta-analysis of stable isotope techniques to investigate postoperative catabolism (2022)
Journal Article
Jaconelli, M., Greenhaff, P. L., Atherton, P. J., Lobo, D. N., & Brook, M. S. (2022). The effects of elective abdominal surgery on protein turnover: A meta-analysis of stable isotope techniques to investigate postoperative catabolism. Clinical Nutrition, 41(3), 709-722. https://doi.org/10.1016/j.clnu.2022.01.023

Background & aims Elective surgery induces skeletal muscle wasting driven by an imbalance between muscle protein synthesis and breakdown. From examination of diverse stable isotope tracer techniques, the dynamic processes driving this imbalance ar... Read More about The effects of elective abdominal surgery on protein turnover: A meta-analysis of stable isotope techniques to investigate postoperative catabolism.

Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids (2022)
Journal Article
Babaei-Jadidi, R., Kashfi, H., Alelwani, W., Bakhtiari, A., Kattan, S. W., Mansouri, O. A., …Nateri, A. S. (2022). Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids. Oncogenesis, 11, Article 4. https://doi.org/10.1038/s41389-021-00376-1

Little is known about the role of microRNAs (miRNAs) in rewiring the metabolism within tumours and adjacent non-tumour bearing normal tissue and their potential in cancer therapy. This study aimed to investigate the relationship between deregulated m... Read More about Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids.

Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review (2022)
Journal Article
Baamer, R. M., Iqbal, A., Lobo, D. N., Knaggs, R. D., Levy, N. A., & Toh, L. S. (2022). Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review. British Journal of Anaesthesia, 128(5), 874-888. https://doi.org/10.1016/j.bja.2021.11.032

Background: We aimed to appraise the evidence relating to the measurement properties of unidimensional tools to quantify pain after surgery. Furthermore, we wished to identify the tools used to assess interference of pain with functional recovery. Me... Read More about Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review.

Current Issues in the Use of Opioids for the Management of Postoperative Pain: A Review (2021)
Journal Article
Macintyre, P. E., Quinlan, J., Levy, N., & Lobo, D. N. (2022). Current Issues in the Use of Opioids for the Management of Postoperative Pain: A Review. JAMA Surgery, 157(2), 158-166. https://doi.org/10.1001/jamasurg.2021.6210

Importance: Uncontrolled and indiscriminate prescribing of opioids has led to an opioid crisis that started in North America and spread throughout high-income countries. The aim of this narrative review was to explore some of the current issues surro... Read More about Current Issues in the Use of Opioids for the Management of Postoperative Pain: A Review.

The importance of protein sources to support muscle anabolism in cancer: An expert group opinion (2021)
Journal Article
Ford, K. L., Arends, J., Atherton, P. J., Engelen, M. P., Gonçalves, T. J., Laviano, A., …Prado, C. M. (2022). The importance of protein sources to support muscle anabolism in cancer: An expert group opinion. Clinical Nutrition, 41(1), 192-201. https://doi.org/10.1016/j.clnu.2021.11.032

This opinion paper presents a short review of the potential impact of protein on muscle anabolism in cancer, which is associated with better patient outcomes. Protein source is a topic of interest for patients and clinicians, partly due to recent emp... Read More about The importance of protein sources to support muscle anabolism in cancer: An expert group opinion.