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All Outputs (31)

In vivo Magnetic Resonance Imaging of Tumor Protease Activity (2014)
Journal Article
Haris, M., Singh, A., Mohammed, I., Ittyerah, R., Nath, K., Nanga, R. P. R., …Reddy, R. (2015). In vivo Magnetic Resonance Imaging of Tumor Protease Activity. Scientific Reports, 4(1), Article 6081. https://doi.org/10.1038/srep06081

Increased expression of cathepsins has diagnostic as well as prognostic value in several types of cancer. Here, we demonstrate a novel magnetic resonance imaging (MRI) method, which uses poly-L-glutamate (PLG) as an MRI probe to map cathepsin express... Read More about In vivo Magnetic Resonance Imaging of Tumor Protease Activity.

In vitro studies on the antimicrobial peptide human beta-defensin 9 (HBD9): signalling pathways and pathogen-related response (an American Ophthalmological Society thesis) (2014)
Journal Article
Dua, H. S., Otri, A. M., Hopkinson, A., & Mohammed, I. (2014). In vitro studies on the antimicrobial peptide human beta-defensin 9 (HBD9): signalling pathways and pathogen-related response (an American Ophthalmological Society thesis). Transactions of the American Ophthalmological Society, 112, 50-73

Purpose: Human β-defensins (HBDs) are an important part of the innate immune host defense at the ocular surface. Unlike other defensins, expression of HBD9 at the ocular surface is reduced during microbial infection, but activation of toll-like recep... Read More about In vitro studies on the antimicrobial peptide human beta-defensin 9 (HBD9): signalling pathways and pathogen-related response (an American Ophthalmological Society thesis).

Deletion of Crry and DAF on Murine Platelets Stimulates Thrombopoiesis and Increases Factor H-Dependent Resistance of Peripheral Platelets to Complement Attack (2013)
Journal Article
Barata, L., Miwa, T., Sato, S., Kim, D., Mohammed, I., & Song, W. (2013). Deletion of Crry and DAF on Murine Platelets Stimulates Thrombopoiesis and Increases Factor H-Dependent Resistance of Peripheral Platelets to Complement Attack. Journal of Immunology, 190(6), 2886-2895. https://doi.org/10.4049/jimmunol.1202536

Complement receptor 1-related gene/protein y (Crry) and decay-accelerating factor (DAF) are two murine membrane C3 complement regulators with overlapping functions. Crry deletion is embryonically lethal whereas DAF-deficient mice are generally health... Read More about Deletion of Crry and DAF on Murine Platelets Stimulates Thrombopoiesis and Increases Factor H-Dependent Resistance of Peripheral Platelets to Complement Attack.

Increased Expression of Hepcidin and Toll-Like Receptors 8 and 10 in Viral Keratitis (2011)
Journal Article
Mohammed, I., Abedin, A., Tsintzas, K., Abedin, S. A., Otri, A. M., Hopkinson, A., …Dua, H. S. (2011). Increased Expression of Hepcidin and Toll-Like Receptors 8 and 10 in Viral Keratitis. Cornea, 30(8), 899-904. https://doi.org/10.1097/ICO.0b013e31820126e5

Purpose: Antimicrobial peptides (AMPs) and toll-like receptors (TLRs) form part of the “chemical barrier” of the ocular surface to microbes. Evidence suggests that pathogen recognition by TLR releases AMPs, altering AMP-TLR profiles in pathologic... Read More about Increased Expression of Hepcidin and Toll-Like Receptors 8 and 10 in Viral Keratitis.

Signalling pathways involved in ribonuclease-7 expression (2010)
Journal Article
Mohammed, I., Yeung, A., Abedin, A., Hopkinson, A., & Dua, H. S. (2011). Signalling pathways involved in ribonuclease-7 expression. Cellular and Molecular Life Sciences, 68(11), 1941-1952. https://doi.org/10.1007/s00018-010-0540-2

Antimicrobial peptides are host defence molecules that play a potential role in preventing infection at the epithelial surfaces. Ribonuclease (RNase)-7 has been shown to possess a broad spectrum of microbicidal activity against various pathogens. Her... Read More about Signalling pathways involved in ribonuclease-7 expression.

Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristics (2010)
Journal Article
Kulkarni, B. B., Tighe, P. J., Mohammed, I., Yeung, A. M., Powe, D. G., Hopkinson, A., …Dua, H. S. (2010). Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristics. BMC Genomics, 11(1), Article 526. https://doi.org/10.1186/1471-2164-11-526

Background: The Limbal epithelial crypt (LEC) is a solid cord of cells, approximately 120 microns long. It arises from the undersurface of interpalisade rete ridges of the limbal palisades of Vogt and extends deeper into the limbal stroma parallel or... Read More about Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristics.

Localization and Gene Expression of Human β-Defensin 9 at the Human Ocular Surface Epithelium (2010)
Journal Article
Mohammed, I., Suleman, H., Otri, A. M., Kulkarni, B. B., Chen, P., Hopkinson, A., & Dua, H. S. (2010). Localization and Gene Expression of Human β-Defensin 9 at the Human Ocular Surface Epithelium. Investigative Ophthalmology & Visual Science, 51(9), 4677-4682. https://doi.org/10.1167/iovs.10-5334

Purpose: Antimicrobial peptides (AMPs) are multifunctional host defense molecules. Human β-defensin 9 (HBD9) has previously been shown to be downregulated during ocular surface (OS) infection or inflammation. Here, the authors aimed to study localiz... Read More about Localization and Gene Expression of Human β-Defensin 9 at the Human Ocular Surface Epithelium.

Epidermal Growth Factor Variations in Amniotic Membrane Used for Ex Vivo Tissue Constructs (2009)
Journal Article
Gicquel, J., Dua, H. S., Brodie, A., Mohammed, I., Suleman, H., Lazutina, E., …Hopkinson, A. (2009). Epidermal Growth Factor Variations in Amniotic Membrane Used for Ex Vivo Tissue Constructs. Tissue Engineering: Parts A, B, and C, 15(8), 1919-1927. https://doi.org/10.1089/ten.tea.2008.0432

Introduction: The amniotic membrane (AM) is used for engineering ex vivo tissue constructs used in ocular surface reconstruction. Epidermal growth factor (EGF) content of the AM is believed to play a key role in supporting corneal epithelial cell exp... Read More about Epidermal Growth Factor Variations in Amniotic Membrane Used for Ex Vivo Tissue Constructs.

A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection (2008)
Journal Article
Abedin, A., Mohammed, I., Hopkinson, A., & Dua, H. S. (2008). A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection. Investigative Ophthalmology & Visual Science, 49(1), 28-33. https://doi.org/10.1167/iovs.07-0645

PURPOSE: Antimicrobial peptides (AMPs) are cationic host defense peptides with microbicidal and cell-signaling properties. They show promise as potential therapeutic agents. In the present study, a beta-defensin AMP gene was isolated from the ocular... Read More about A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection.