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Preoperative carbohydrate supplementation attenuates post-surgery insulin resistance via reduced inflammatory inhibition of the insulin-mediated restraint on muscle pyruvate dehydrogenase kinase 4 expression (2014)
Journal Article
Fosse Gjessing, P., Constantin-Teodosiu, D., Hagve, M., Lobo, D. N., Revhaug, A., & Irtun, Ø. (2015). Preoperative carbohydrate supplementation attenuates post-surgery insulin resistance via reduced inflammatory inhibition of the insulin-mediated restraint on muscle pyruvate dehydrogenase kinase 4 expression. Clinical Nutrition, 34(6), 1177-1183. https://doi.org/10.1016/j.clnu.2014.12.004

Functional recovery is considered the most important target: a survey of dedicated professionals (2014)
Journal Article
Aahlin, E. K., von Meyenfeldt, M., Dejong, C. H., Ljungqvist, O., Fearon, K. C., Lobo, D. N., …Lassen, K. (2014). Functional recovery is considered the most important target: a survey of dedicated professionals. Perioperative Medicine, 3(1), https://doi.org/10.1186/2047-0525-3-5

Background: The aim of this study was to survey the relative importance of postoperative recovery targets and perioperative care items, as perceived by a large group of international dedicated professionals. Methods: A questionnaire with eight posto... Read More about Functional recovery is considered the most important target: a survey of dedicated professionals.

Effect of a Perioperative, Cardiac Output–Guided Hemodynamic Therapy Algorithm on Outcomes Following Major Gastrointestinal Surgery: A Randomized Clinical Trial and Systematic Review (2014)
Journal Article
Lobo, D., MacDonald, N., Pearse, R. M., Parnell, W., Harrison, D. A., Niebrzegowska, E., …Treasure, T. (2014). Effect of a Perioperative, Cardiac Output–Guided Hemodynamic Therapy Algorithm on Outcomes Following Major Gastrointestinal Surgery: A Randomized Clinical Trial and Systematic Review. Journal of the American Medical Association, 311(21), 2180-2190. https://doi.org/10.1001/jama.2014.5305

A Randomized, Controlled, Double-Blind Crossover Study on the Effects of 1-L Infusions of 6% Hydroxyethyl Starch Suspended in 0.9% Saline (Voluven) and a Balanced Solution (Plasma Volume Redibag) on Blood Volume, Renal Blood Flow Velocity, and Renal Cortical Tissue Perfusion in Healthy Volunteers (2014)
Journal Article
Chowdhury, A., Fox, E., Francis, S., & Lobo, D. (2014). A Randomized, Controlled, Double-Blind Crossover Study on the Effects of 1-L Infusions of 6% Hydroxyethyl Starch Suspended in 0.9% Saline (Voluven) and a Balanced Solution (Plasma Volume Redibag) on Blood Volume, Renal Blood Flow Velocity, and Renal Cortical Tissue Perfusion in Healthy Volunteers. Annals of Surgery, 259(5), 881–887. https://doi.org/10.1097/SLA.0000000000000324

Objective: We compared the effects of intravenous administration of 6% hydroxyethyl starch (maize-derived) in 0.9% saline (Voluven; Fresenius Kabi, Runcorn, United Kingdom) and a “balanced” preparation of 6% hydroxyethyl starch (potato-derived) [Plas... Read More about A Randomized, Controlled, Double-Blind Crossover Study on the Effects of 1-L Infusions of 6% Hydroxyethyl Starch Suspended in 0.9% Saline (Voluven) and a Balanced Solution (Plasma Volume Redibag) on Blood Volume, Renal Blood Flow Velocity, and Renal Cortical Tissue Perfusion in Healthy Volunteers.

The pathophysiology of fluid and electrolyte balance in the older adult surgical patient (2013)
Journal Article
El-Sharkawy, A. M., Sahota, O., Maughan, R. J., & Lobo, D. N. (2013). The pathophysiology of fluid and electrolyte balance in the older adult surgical patient. Clinical Nutrition, 33(1), https://doi.org/10.1016/j.clnu.2013.11.010

Background & aims: Age-related physiological changes predispose even the healthy older adult to fluid and electrolyte abnormalities which can cause morbidity and mortality. The aim of this narrative review is to highlight key aspects of age-relat... Read More about The pathophysiology of fluid and electrolyte balance in the older adult surgical patient.

The presence of tumour-associated lymphocytes confers a good prognosis in pancreatic ductal adenocarcinoma: an immunohistochemical study of tissue microarrays (2013)
Journal Article
Tewari, N., Zaitoun, A. M., Arora, A., Madhusudan, S., Ilyas, M., & Lobo, D. N. (2013). The presence of tumour-associated lymphocytes confers a good prognosis in pancreatic ductal adenocarcinoma: an immunohistochemical study of tissue microarrays. BMC Cancer, 13, Article 436. https://doi.org/10.1186/1471-2407-13-436

Background Tumour-associated lymphocytes (TALs) have been linked with good prognosis in several solid tumours. This study aimed to evaluate the prognostic significance of CD3, CD8 and CD20 positive lymphocytes in pancreatic ductal adenocarcinoma.... Read More about The presence of tumour-associated lymphocytes confers a good prognosis in pancreatic ductal adenocarcinoma: an immunohistochemical study of tissue microarrays.

Are DNA repair factors promising biomarkers for personalized therapy in gastric cancer? (2013)
Journal Article
Abdel-Fatah, T., Arora, A., Gorguc, I., Abbotts, R., Beebeejaun, S., Storr, S. J., …Madhusudan, S. (2013). Are DNA repair factors promising biomarkers for personalized therapy in gastric cancer?. Antioxidants and Redox Signaling, 18(18), https://doi.org/10.1089/ars.2012.4873

Chronic inflammation is a driving force for gastric carcinogenesis. Reactive oxygen species (ROS) generated during the inflammatory process generates DNA damage that is processed through the DNA repair pathways. In this study, we profiled key DNA rep... Read More about Are DNA repair factors promising biomarkers for personalized therapy in gastric cancer?.

Intestinal ischemia following laparoscopic surgery: a case series (2013)
Journal Article
Al-Khyatt, W., Thomas, J. D., Humes, D. J., & Lobo, D. N. (2013). Intestinal ischemia following laparoscopic surgery: a case series. Journal of Medical Case Reports, 7(25), Article 25. https://doi.org/10.1186/1752-1947-7-25

Introduction: Intestinal ischemia is a rare complication of laparoscopic surgery. Its prognosis depends on a high index of suspicion and effective early treatment. Case presentation: In the present report, we describe three cases where intestinal i... Read More about Intestinal ischemia following laparoscopic surgery: a case series.

Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy (2012)
Journal Article
Fareed, K. R., Soomro, I. N., Hameed, K., Arora, A., Lobo, D. N., Parsons, S. L., & Madhusudan, S. (2012). Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy. World Journal of Gastroenterology, 18(16), https://doi.org/10.3748/wjg.v18.i16.1915

AIM: To examine cytokeratin-18 (CK-18) and caspase-cleaved CK-18 expression in tumours and correlate with clinicopathological outcomes including tumour regression grade (TRG) response. METHODS: Formalin-fixed human gastro-oesophageal cancers were... Read More about Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy.

Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials (2012)
Journal Article
Varadhan, K. K., Neal, K. R., & Lobo, D. N. (2012). Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials. BMJ, 344(7855), Article 15. https://doi.org/10.1136/bmj.e2156

Objective To compare the safety and efficacy of antibiotic treatment versus appendicectomy for the primary treatment of uncomplicated acute appendicitis. Design Meta-analysis of randomised controlled trials. Population Randomised controlled tri... Read More about Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials.

Knockdown of microRNA-21 Inhibits Proliferation and Increases Cell Death by Targeting Programmed Cell Death 4 (PDCD4) in Pancreatic Ductal Adenocarcinoma (2010)
Journal Article
Bhatti, I., Lee, A., James, V., Hall, R. I., Lund, J. N., Tufarelli, C., …Larvin, M. (2011). Knockdown of microRNA-21 Inhibits Proliferation and Increases Cell Death by Targeting Programmed Cell Death 4 (PDCD4) in Pancreatic Ductal Adenocarcinoma. Journal of Gastrointestinal Surgery, 15(1), 199-208. https://doi.org/10.1007/s11605-010-1381-x