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Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy

Fareed, Khaleel R.; Soomro, Irshad N.; Hameed, Khalid; Arora, Arvind; Lobo, Dileep N.; Parsons, Simon L.; Madhusudan, Srinivasan

Authors

Khaleel R. Fareed

Irshad N. Soomro

Khalid Hameed

Arvind Arora

Dileep N. Lobo

Simon L. Parsons

Srinivasan Madhusudan



Abstract

AIM: To examine cytokeratin-18 (CK-18) and caspase-cleaved CK-18 expression in tumours and correlate with clinicopathological outcomes including tumour regression grade (TRG) response.

METHODS: Formalin-fixed human gastro-oesophageal cancers were constructed into tissue microarrays. The first set consisted of 122 gastric/gastro-oesophageal cancer cases not exposed to neoadjuvant chemotherapy and the second set consisted of 97 gastric/gastro-oesophageal cancer cases exposed to pre-operative platinum-based chemotherapy. Expression of CK-18 and caspase-cleaved CK-18 was investigated using immunohistochemistry.

RESULTS: CK18 was commonly expressed in gastro-oesophageal tumours (92.6%). Fifty-six point seven percent of tumours previously exposed to neoadjuvant chemotherapy were positive for caspase-cleaved CK-18 expression compared to only 24.6% of tumours not previously exposed to neoadjuvant chemotherapy (P = 0.009). In patients who received neoadjuvant chemotherapy, caspase-cleaved cytokeratin-18 expression correlated with favourable TRG response (TRG 1, 2 or 3, P = 0.043).

CONCLUSION: This is the largest study to date of CK-18 and caspase-cleaved CK-18 expression in gastro-oesophageal tumours. We provide the first evidence that caspase-cleaved CK-18 predicts tumour regression with neoadjuvant chemotherapy.

Journal Article Type Article
Publication Date Apr 28, 2012
Journal World Journal of Gastroenterology
Print ISSN 1007-9327
Electronic ISSN 1007-9327
Publisher Baishideng Publishing Group
Peer Reviewed Peer Reviewed
Volume 18
Issue 16
Institution Citation Fareed, K. R., Soomro, I. N., Hameed, K., Arora, A., Lobo, D. N., Parsons, S. L., & Madhusudan, S. (2012). Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy. World Journal of Gastroenterology, 18(16), doi:10.3748/wjg.v18.i16.1915
DOI https://doi.org/10.3748/wjg.v18.i16.1915
Publisher URL http://www.wjgnet.com/1007-9327/abstract/v18/i16/1915.htm
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0





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