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Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy

Fareed, Khaleel R.; Soomro, Irshad N.; Hameed, Khalid; Arora, Arvind; Lobo, Dileep N.; Parsons, Simon L.; Madhusudan, Srinivasan

Authors

Khaleel R. Fareed

Irshad N. Soomro

Khalid Hameed

Arvind Arora

Dileep N. Lobo

Simon L. Parsons



Abstract

AIM: To examine cytokeratin-18 (CK-18) and caspase-cleaved CK-18 expression in tumours and correlate with clinicopathological outcomes including tumour regression grade (TRG) response.

METHODS: Formalin-fixed human gastro-oesophageal cancers were constructed into tissue microarrays. The first set consisted of 122 gastric/gastro-oesophageal cancer cases not exposed to neoadjuvant chemotherapy and the second set consisted of 97 gastric/gastro-oesophageal cancer cases exposed to pre-operative platinum-based chemotherapy. Expression of CK-18 and caspase-cleaved CK-18 was investigated using immunohistochemistry.

RESULTS: CK18 was commonly expressed in gastro-oesophageal tumours (92.6%). Fifty-six point seven percent of tumours previously exposed to neoadjuvant chemotherapy were positive for caspase-cleaved CK-18 expression compared to only 24.6% of tumours not previously exposed to neoadjuvant chemotherapy (P = 0.009). In patients who received neoadjuvant chemotherapy, caspase-cleaved cytokeratin-18 expression correlated with favourable TRG response (TRG 1, 2 or 3, P = 0.043).

CONCLUSION: This is the largest study to date of CK-18 and caspase-cleaved CK-18 expression in gastro-oesophageal tumours. We provide the first evidence that caspase-cleaved CK-18 predicts tumour regression with neoadjuvant chemotherapy.

Citation

Fareed, K. R., Soomro, I. N., Hameed, K., Arora, A., Lobo, D. N., Parsons, S. L., & Madhusudan, S. (2012). Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy. World Journal of Gastroenterology, 18(16), doi:10.3748/wjg.v18.i16.1915

Journal Article Type Article
Publication Date Apr 28, 2012
Deposit Date Apr 1, 2014
Publicly Available Date Apr 1, 2014
Journal World Journal of Gastroenterology
Print ISSN 1007-9327
Electronic ISSN 1007-9327
Publisher Baishideng Publishing Group
Peer Reviewed Peer Reviewed
Volume 18
Issue 16
DOI https://doi.org/10.3748/wjg.v18.i16.1915
Public URL http://eprints.nottingham.ac.uk/id/eprint/2797
Publisher URL http://www.wjgnet.com/1007-9327/abstract/v18/i16/1915.htm
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0





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