All Outputs (6)

Cerebrovascular endothelial cells form transient Notch?dependent cystic structures in zebrafish (2019)
Journal Article
Kugler, E. C., Lessen, M., Daetwyler, S., Chhabria, K., Savage, A. M., Silva, V., …Chico, T. J. (2019). Cerebrovascular endothelial cells form transient Notch‐dependent cystic structures in zebrafish. EMBO Reports, 20(8), https://doi.org/10.15252/embr.201847047

We identify a novel endothelial membrane behaviour in transgenic zebrafish. Cerebral blood vessels extrude large transient spherical structures that persist for an average of 23 min before regressing into the parent vessel. We term these structures "... Read More about Cerebrovascular endothelial cells form transient Notch?dependent cystic structures in zebrafish.

The role of endothelial cilia in postembryonic vascular development (2019)
Journal Article
Elworthy, S., Savage, A. M., Wilkinson, R. N., Malicki, J. J., & Chico, T. J. (2019). The role of endothelial cilia in postembryonic vascular development. Developmental Dynamics, 248(6), 410-425. https://doi.org/10.1002/dvdy.40

BACKGROUND: Cilia are essential for morphogenesis and maintenance of many tissues. Loss-of-function of cilia in early Zebrafish development causes a range of vascular defects, including cerebral hemorrhage and reduced arterial vascular mural cell co... Read More about The role of endothelial cilia in postembryonic vascular development.

TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells (2019)
Journal Article
Arhatte, M., Gunaratne, G. S., El Boustany, C., Kuo, I. Y., Moro, C., Duprat, F., …Patel, A. (2019). TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells. Nature Communications, 10(1), Article 2024. https://doi.org/10.1038/s41467-019-10045-y

Mutations in the polycystins cause autosomal dominant polycystic kidney disease (ADPKD). Here we show that transmembrane protein 33 (TMEM33) interacts with the ion channel polycystin-2 (PC2) at the endoplasmic reticulum (ER) membrane, enhancing its o... Read More about TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells.

tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis (2019)
Journal Article
Savage, A. M., Kurusamy, S., Chen, Y., Jiang, Z., Chhabria, K., MacDonald, R. B., …Wilkinson, R. N. (2019). tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis. Nature Communications, 10, Article 732. https://doi.org/10.1038/s41467-019-08590-7

Angiogenesis requires co-ordination of multiple signalling inputs to regulate the behaviour of endothelial cells (ECs) as they form vascular networks. Vascular endothelial growth factor (VEGF) is essential for angiogenesis and induces downstream sign... Read More about tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis.

Venous identity requires BMP signalling through ALK3 (2019)
Journal Article
Neal, A., Nornes, S., Payne, S., Wallace, M. D., Fritzsche, M., Louphrasitthiphol, P., …De Val, S. (2019). Venous identity requires BMP signalling through ALK3. Nature Communications, 10(1), 1-18. https://doi.org/10.1038/s41467-019-08315-w

Venous endothelial cells are molecularly and functionally distinct from their arterial counterparts. Although veins are often considered the default endothelial state, genetic manipulations can modulate both acquisition and loss of venous fate, sugge... Read More about Venous identity requires BMP signalling through ALK3.

The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish (2018)
Journal Article
Chhabria, K., Plant, K., Bandmann, O., Wilkinson, R. N., Martin, C., Kugler, E., …Howarth, C. (2020). The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish. Journal of Cerebral Blood Flow and Metabolism, 40(2), 298-313. https://doi.org/10.1177/0271678X18810615

Neurovascular coupling (through which local cerebral blood flow changes in response to neural activation are mediated) is impaired in many diseases including diabetes. Current preclinical rodent models of neurovascular coupling rely on invasive surge... Read More about The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish.