All Outputs (3314)

Strategies for Integrating Metal Nanoparticles with Two-Photon Polymerization Process: Toward High Resolution Functional Additive Manufacturing (2023)
Journal Article

This study reports the successful fabrication of complex 3D metal nanoparticle–polymer nanocomposites using two-photon polymerization (2PP). Three complementary strategies are detailed: in situ formation of metal nanoparticles (MeNPs) through a singl... Read More about Strategies for Integrating Metal Nanoparticles with Two-Photon Polymerization Process: Toward High Resolution Functional Additive Manufacturing.

Learning to think, perform and act with integrity: does teacher education have a signature pedagogy, and why does this matter? (2023)
Journal Article

Unprecedented reform to teacher education in England, through the Initial Teacher Training Market Review, led to the threat of removal of the right for established providers to offer programmes of initial teacher education beyond 2024 without reaccre... Read More about Learning to think, perform and act with integrity: does teacher education have a signature pedagogy, and why does this matter?.

Self-management interventions for children and young people with sickle cell disease: A systematic review (2023)
Journal Article

AbstractBackgroundIncreasing numbers of interventions are being developed to support self‐management for children and young people (CYP) with sickle cell disease (SCD), but no systematic review has systematically synthesized this evidence regarding t... Read More about Self-management interventions for children and young people with sickle cell disease: A systematic review.

Differential remodelling in small and large murine airways revealed by novel whole lung airway analysis (2023)
Journal Article

Airway remodelling occurs in chronic asthma leading to increased airway smooth muscle (ASM) mass and extra-cellular matrix (ECM) deposition. Whilst extensively studied in murine airways, studies report only selected larger airways at one time point m... Read More about Differential remodelling in small and large murine airways revealed by novel whole lung airway analysis.

Highly electron deficient diketopyrrolopyrroles (2023)
Journal Article

The synthesis, spectroelectrochemical and structural characteristics of highly electron-accepting diketopyrrrolopyrrole (DPP) molecules with adjoining pyridinium rings is reported, along with an assessment of their toxicity, which is apparently low.... Read More about Highly electron deficient diketopyrrolopyrroles.

Perfect-Lens Theory Enables Metasurface Reflectors for Subwavelength Focusing (2023)
Journal Article

Breaking the so-called diffraction limit on the resolution of optical devices and achieving subwavelength focusing requires tailoring the evanescent spectrum of wave fields. There are several possible approaches, all of which have limitations, such a... Read More about Perfect-Lens Theory Enables Metasurface Reflectors for Subwavelength Focusing.

‘Sissy capital’ and the governance of non-normative genders in China’s platform economy (2023)
Journal Article

This article examines Chinese government censorship in the intersection between queer and fan cultures and the government’s regulation of big tech companies and platform economies in the 2020s conjuncture. In the context of booming platform industrie... Read More about ‘Sissy capital’ and the governance of non-normative genders in China’s platform economy.

Comparative efficacy of exercise therapy and oral non-steroidal anti-inflammatory drugs and paracetamol for knee or hip osteoarthritis: a network meta-analysis of randomised controlled trials (2023)
Journal Article

OBJECTIVE: Clinical guidelines recommend exercise as a core treatment for knee or hip osteoarthritis (OA). However, how its analgesic effect compares to analgesics, for example, oral non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol-the... Read More about Comparative efficacy of exercise therapy and oral non-steroidal anti-inflammatory drugs and paracetamol for knee or hip osteoarthritis: a network meta-analysis of randomised controlled trials.

Artificial intelligence-driven wearable technologies for neonatal cardiorespiratory monitoring: Part 1 wearable technology (2023)
Journal Article

Abstract: With the development of Artificial Intelligence techniques, smart health monitoring is becoming more popular. In this study, we investigate the trend of wearable sensors being adopted and developed in neonatal cardiorespiratory monitoring.... Read More about Artificial intelligence-driven wearable technologies for neonatal cardiorespiratory monitoring: Part 1 wearable technology.

‘Getting to know you through music.’ Music therapists’ unique ways of ‘knowing’ their clients and our collective responsibilities to articulate our implicit knowledge (2023)
Journal Article

“How do you get to know your client’s inner-world so well?” I am often amazed by the depth of insight music therapy colleagues share about their clients during clinical peer-supervision. Of course, colleagues from other disciplines I closely work wit... Read More about ‘Getting to know you through music.’ Music therapists’ unique ways of ‘knowing’ their clients and our collective responsibilities to articulate our implicit knowledge.

Concept and Demonstration of a Coaxial Magnetic Coupling with Electromagnetic Disconnection for Aircraft Permanent Magnet Generators (2023)
Journal Article

The application of more electrified systems in aircraft is required to achieve the target of a more sustainable aviation industry. This in turn relies on the development of new electro-mechanical devices to ensure reliability of critical aircraft fun... Read More about Concept and Demonstration of a Coaxial Magnetic Coupling with Electromagnetic Disconnection for Aircraft Permanent Magnet Generators.

Dynamic, adaptive sampling during nanopore sequencing using Bayesian experimental design (2023)
Journal Article

Nanopore sequencers can select which DNA molecules to sequence, rejecting a molecule after analysis of a small initial part. Currently, selection is based on predetermined regions of interest that remain constant throughout an experiment. Sequencing... Read More about Dynamic, adaptive sampling during nanopore sequencing using Bayesian experimental design.

Towards Shaping the Future of Responsible AI in Africa (2023)
Book Chapter

Artificial Intelligence (AI) presents unprecedented opportunities for Africa. Increasingly, AI and other emerging technologies are being deployed in African contexts—healthcare, agriculture, sociopolitical processes, businesses and education—in ways... Read More about Towards Shaping the Future of Responsible AI in Africa.

Reproducible microbiome composition signatures of anxiety and depressive symptoms (2023)
Journal Article

The gut microbiome is a significant contributor to mental health, with growing evidence linking its composition to anxiety and depressive disorders. Gut microbiome composition is associated with signs of anxiety and depression both in clinically diag... Read More about Reproducible microbiome composition signatures of anxiety and depressive symptoms.

Environmental and farming practice controls of productivity of Cyrtosperma merkusii (giant swamp taro), an underutilised wetland and potential paludiculture crop (2023)
Journal Article

Growing recognition of the potential vulnerabilities of major crop systems has spurred a growing interest in the potential of alternative crops which may be resilient to climate change and also help mitigate its effects. In Indonesia, such issues are... Read More about Environmental and farming practice controls of productivity of Cyrtosperma merkusii (giant swamp taro), an underutilised wetland and potential paludiculture crop.

Base editing enables duplex point mutagenesis in Clostridium autoethanogenum at the price of numerous off-target mutations (2023)
Journal Article

Base editors are recent multiplex gene editing tools derived from the Cas9 nuclease of Streptomyces pyogenes. They can target and modify a single nucleotide in the genome without inducing double-strand breaks (DSB) of the DNA helix. As such, they hol... Read More about Base editing enables duplex point mutagenesis in Clostridium autoethanogenum at the price of numerous off-target mutations.

Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics (2023)
Journal Article

A new generation of dual-target μ opioid receptor (MOR) agonist/dopamine D3 receptor (D3R) antagonist/partial agonists with optimized physicochemical properties was designed and synthesized. Combining in vitro cell-based on-target/off-target affinity... Read More about Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics.

Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided “immune-hot” colorectal cancers (2023)
Journal Article

Introduction: Characterization of the tumour immune infiltrate (notably CD8+ T-cells) has strong predictive survival value for cancer patients. Quantification of CD8 T-cells alone cannot determine antigenic experience, as not all infiltrating T-cells... Read More about Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided “immune-hot” colorectal cancers.

Morphological and osteological characterization of indigenous domestic chickens (Gallus gallus domesticus): validation of Rensch’s, Bergmann’s and Allen’s rules (2023)
Journal Article

Ecogeographical habitat heterogeneity in wild endotherm species results in morphological variability associated with physiological mechanisms for maintaining their body temperature at a thermoneutral state in different environments. This habitat-indu... Read More about Morphological and osteological characterization of indigenous domestic chickens (Gallus gallus domesticus): validation of Rensch’s, Bergmann’s and Allen’s rules.

The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer (2023)
Journal Article

Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many cancer types... Read More about The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer.