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Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as novel risk factors for Alzheimers Disease (2022)
Preprint / Working Paper
Holstege, H., Hulsman, M., Charbonnier, C., Grenier-Boley, B., Quenez, O., Grozeva, D., …Lambert, J.-C. Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as novel risk factors for Alzheimers Disease

The genetic component of Alzheimer’s disease (AD) has been mainly assessed using Genome Wide Association Studies (GWAS), which do not capture the risk contributed by rare variants. Here, we compared the gene-based burden of rare damaging variants in... Read More about Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as novel risk factors for Alzheimers Disease.

Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications (2022)
Journal Article
Power, R. N., Cavanagh, B. L., Dixon, J. E., Curtin, C. M., & O’Brien, F. J. (2022). Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications. International Journal of Molecular Sciences, 23(3), Article 1460. https://doi.org/10.3390/ijms23031460

Non-viral gene delivery has become a popular approach in tissue engineering, as it permits the transient delivery of a therapeutic gene, in order to stimulate tissue repair. However, the efficacy of non-viral delivery vectors remains an issue. Our la... Read More about Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications.

Planning Perspectives on Rural Connected, Autonomous and Electric Vehicle Implementation (2022)
Journal Article
Walters, J. G., Marsh, S., & Rodrigues, L. (2022). Planning Perspectives on Rural Connected, Autonomous and Electric Vehicle Implementation. Sustainability, 14(3), Article 1477. https://doi.org/10.3390/su14031477

Connected, autonomous and electric vehicles (CAEV) are a powerful combined transport technology looking to disrupt the automotive sector and drive the transition to safe, accessible, clean and sustainable transport systems. The trialling of private,... Read More about Planning Perspectives on Rural Connected, Autonomous and Electric Vehicle Implementation.

“Drunk People Are on a Different Level”: A Qualitative Study of Reflections From Students About Transitioning and Adapting to United Kingdom University as a Person Who Drinks Little or No Alcohol (2022)
Journal Article
Cook, E., Davies, E. B., & Jones, K. A. (2022). “Drunk People Are on a Different Level”: A Qualitative Study of Reflections From Students About Transitioning and Adapting to United Kingdom University as a Person Who Drinks Little or No Alcohol. Frontiers in Psychology, 12, Article 702662. https://doi.org/10.3389/fpsyg.2021.702662

Background: Though sobriety in young people is on the rise, students who drink little or no alcohol may experience social exclusion at University, impacting well-being. We aim to understand the social experiences of United Kingdom (UK) undergraduate... Read More about “Drunk People Are on a Different Level”: A Qualitative Study of Reflections From Students About Transitioning and Adapting to United Kingdom University as a Person Who Drinks Little or No Alcohol.

Nonequilibrium Dark Space Phase Transition (2022)
Journal Article
Carollo, F., & Lesanovsky, I. (2022). Nonequilibrium Dark Space Phase Transition. Physical Review Letters, 128(4), Article 040603. https://doi.org/10.1103/PhysRevLett.128.040603

We introduce the concept of dark space phase transition, which may occur in open many-body quantum systems where irreversible decay, interactions, and quantum interference compete. Our study is based on a quantum many-body model that is inspired by c... Read More about Nonequilibrium Dark Space Phase Transition.

Cattle farmer psychosocial profiles and their association with control strategies for bovine viral diarrhea (2022)
Journal Article
Prosser, N. S., Green, M. J., Ferguson, E., Tildesley, M. J., Hill, E. M., Keeling, M. J., & Kaler, J. (2022). Cattle farmer psychosocial profiles and their association with control strategies for bovine viral diarrhea. Journal of Dairy Science, 105(4), 3559-3573. https://doi.org/10.3168/jds.2021-21386

Bovine viral diarrhea (BVD) is endemic in the United Kingdom and causes major economic losses. Control is largely voluntary for individual farmers and is likely to be influenced by psychosocial factors, such as altruism, trust, and psychological prox... Read More about Cattle farmer psychosocial profiles and their association with control strategies for bovine viral diarrhea.

Daily Bread: Women’s Self-Help Microfinance and the Social Meanings of Money (2022)
Journal Article
Bott, E., Ojha, S., Mini, S., Smyth, A. R., Kamal Kumar, R., Choudhary, S., & Yaron, G. (2023). Daily Bread: Women’s Self-Help Microfinance and the Social Meanings of Money. Sociological Research Online, 28(2), 442-461. https://doi.org/10.1177/13607804211058745

In this article, we explore the impacts and implications of ‘Rojiroti’, a women’s self-help group (SHG) microfinance scheme operating in poor communities in Bihar, India. We focus particularly on how improvements found in women’s circumstances and in... Read More about Daily Bread: Women’s Self-Help Microfinance and the Social Meanings of Money.

Toward a reflexive mathematics education within local and global relations: thinking from critical scholarship on mathematics education within the sociopolitical, global citizenship education and decoloniality (2022)
Journal Article
le Roux, K., & Swanson, D. M. (2022). Toward a reflexive mathematics education within local and global relations: thinking from critical scholarship on mathematics education within the sociopolitical, global citizenship education and decoloniality. Research in Mathematics Education, 23(3), 323-337. https://doi.org/10.1080/14794802.2021.1993978

Education commonly is positioned as central to developing citizens who can address so-called global challenges. Responses are identifiable in global citizenship education, which may recruit mathematics into interdisciplinary relationships, and within... Read More about Toward a reflexive mathematics education within local and global relations: thinking from critical scholarship on mathematics education within the sociopolitical, global citizenship education and decoloniality.

Model-Based Optimization of Laser Excitation and Detection Improves Spectral Contrast in Noninvasive Diffuse Raman Spectroscopy (2022)
Journal Article
Dooley, M. J., Paterson, T., Dexter, L., Matousek, P., Dehghani, H., & Notingher, I. (2022). Model-Based Optimization of Laser Excitation and Detection Improves Spectral Contrast in Noninvasive Diffuse Raman Spectroscopy. Applied Spectroscopy, 76(7), 801-811. https://doi.org/10.1177/00037028211072900

Spatially offset Raman spectroscopy (SORS) is a powerful technique for subsurface molecular analysis of optically turbid samples. Numerical modeling of light propagation has been used to investigate opportunities for improving spectral contrast and s... Read More about Model-Based Optimization of Laser Excitation and Detection Improves Spectral Contrast in Noninvasive Diffuse Raman Spectroscopy.

Establishing an In Vitro 3D Spheroid Model to Study Medulloblastoma Drug Response and Tumor Dissemination (2022)
Journal Article
Roper, S. J., & Coyle, B. (2022). Establishing an In Vitro 3D Spheroid Model to Study Medulloblastoma Drug Response and Tumor Dissemination. Current Protocols, 2(1), Article e357. https://doi.org/10.1002/cpz1.357

Medulloblastoma is the most common malignant pediatric brain tumor. Current treatment involves surgery, chemotherapy, and craniospinal radiotherapy, and these are associated with a significant reduction in quality of life. Metastatic dissemination at... Read More about Establishing an In Vitro 3D Spheroid Model to Study Medulloblastoma Drug Response and Tumor Dissemination.

Safety and effectiveness of do-it-yourself artificial pancreas system compared with continuous subcutaneous insulin infusions in combination with free style libre in people with type 1 diabetes (2022)
Journal Article
Patel, R., Crabtree, T. S., Taylor, N., Langeland, L., Gazis, A. (., Mendis, B., …Idris, I. (2022). Safety and effectiveness of do-it-yourself artificial pancreas system compared with continuous subcutaneous insulin infusions in combination with free style libre in people with type 1 diabetes. Diabetic Medicine, 39(5), Article e14793. https://doi.org/10.1111/dme.14793

Aims: The use of do-it-yourself artificial pancreas systems (DIYAPS) among people with type 1 diabetes is increasing. At present, it is unclear how DIYAPS compares with other technologies such as FreeStyle Libre (FSL) and continuous subcutaneous insu... Read More about Safety and effectiveness of do-it-yourself artificial pancreas system compared with continuous subcutaneous insulin infusions in combination with free style libre in people with type 1 diabetes.

Tropical peatlands in the anthropocene: Lessons from the past (2022)
Journal Article
Cole, L. E., Åkesson, C. M., Hapsari, K. A., Hawthorne, D., Roucoux, K. H., Girkin, N. T., Cooper, H. V., Ledger, M. J., O'Reilly, P., & Thornton, S. A. (2022). Tropical peatlands in the anthropocene: Lessons from the past. Anthropocene, 37, 100324. https://doi.org/10.1016/j.ancene.2022.100324

The status of tropical peatlands, one of Earth's most efficient natural carbon stores, is of increasing international concern as they experience rising threat from deforestation and drainage. Peatlands form over thousands of years, where waterlogged... Read More about Tropical peatlands in the anthropocene: Lessons from the past.

Fear memory modulation by incentive down and up-shifts (2022)
Journal Article
Mugnaini, M., Alfei, J. M., Bueno, A. M., Ferrer Monti, R. I., & Urcelay, G. P. (2022). Fear memory modulation by incentive down and up-shifts. Behavioural Brain Research, 422, Article 113766. https://doi.org/10.1016/j.bbr.2022.113766

Research on retrieval-induced malleability of maladaptive emotional memories has been mostly focused on the effect of drugs and extinction (i.e. post-retrieval extinction). Only a few studies addressed post-retrieval appetitive-aversive interactions.... Read More about Fear memory modulation by incentive down and up-shifts.

How technology-enhanced experiential e-learning can facilitate the development of person-centred communication skills online for health-care students: a qualitative study (2022)
Journal Article
Liao, F., Murphy, D., Wu, J. C., Chen, C. Y., Chang, C. C., & Tsai, P. F. (2022). How technology-enhanced experiential e-learning can facilitate the development of person-centred communication skills online for health-care students: a qualitative study. BMC Medical Education, 22, Article 60. https://doi.org/10.1186/s12909-022-03127-x

Background: The COVID-19 pandemic brought a new challenge to medical education—health-care students had fewer opportunities to interact with and treat real patients in clinical settings. Interpersonal communication skills are often developed through... Read More about How technology-enhanced experiential e-learning can facilitate the development of person-centred communication skills online for health-care students: a qualitative study.

Dark matter in astrophysics/cosmology (2022)
Journal Article
Green, A. M. (2022). Dark matter in astrophysics/cosmology. SciPost Physics Lecture Notes, https://doi.org/10.21468/SciPostPhysLectNotes.37

These lecture notes aim to provide an introduction to dark matter from the perspective of astrophysics/cosmology. We start with a rapid overview of cosmology, including the evolution of the Universe, its thermal history and structure formation. Then... Read More about Dark matter in astrophysics/cosmology.

The order of presentation in trials: Plaintive plaintiffs (2022)
Journal Article
D'Agostino, E., & Seidmann, D. J. (2022). The order of presentation in trials: Plaintive plaintiffs. Games and Economic Behavior, 132, 328-336. https://doi.org/10.1016/j.geb.2022.01.009

Is it better to present evidence first or second in trials if witnesses cannot lie, and the litigants share all available witnesses? We address this question by defining preferences over playing games via their equilibrium correspondences. Exploiting... Read More about The order of presentation in trials: Plaintive plaintiffs.

Inconsistency indices in pairwise comparisons: an improvement of the Consistency Index (2022)
Journal Article
Sato, Y., & Tan, K. H. (2022). Inconsistency indices in pairwise comparisons: an improvement of the Consistency Index. Annals of Operations Research, https://doi.org/10.1007/s10479-021-04431-3

The Consistency Index and the Consistency Ratio of the analytic hierarchy process (AHP) were designed to measure the ratio of inconsistent judgments among pairwise comparisons (PCs), which have been the principal indices for the past four decades. De... Read More about Inconsistency indices in pairwise comparisons: an improvement of the Consistency Index.