All Outputs (3830)

ELK-1 ubiquitination status and transcriptional activity are modulated independently of F-Box protein FBXO25 (2021)
Journal Article
Quintero-Barceinas, R. S., Gehringer, F., Ducker, C., Saxton, J., & Shaw, P. E. (2021). ELK-1 ubiquitination status and transcriptional activity are modulated independently of F-Box protein FBXO25. Journal of Biological Chemistry, 296, Article 100214. https://doi.org/10.1074/jbc.ra120.014616

The mitogen-responsive, ETS-domain transcription factor ELK-1 stimulates the expression of immediate early genes at the onset of the cell cycle and participates in early developmental programming. ELK-1 is subject to multiple levels of posttranslatio... Read More about ELK-1 ubiquitination status and transcriptional activity are modulated independently of F-Box protein FBXO25.

Community Occupational Therapy for people with dementia and family carers (COTiD-UK) versus treatment as usual (Valuing Active Life in Dementia [VALID]) study: A single-blind, randomised controlled trial (2021)
Journal Article
Wenborn, J., O’Keeffe, A. G., Mountain, G., Moniz-Cook, E., King, M., Omar, R. Z., …Orrell, M. (2021). Community Occupational Therapy for people with dementia and family carers (COTiD-UK) versus treatment as usual (Valuing Active Life in Dementia [VALID]) study: A single-blind, randomised controlled trial. PLoS Medicine, 18(1), Article e1003433. https://doi.org/10.1371/journal.pmed.1003433

© 2021 Wenborn et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cr... Read More about Community Occupational Therapy for people with dementia and family carers (COTiD-UK) versus treatment as usual (Valuing Active Life in Dementia [VALID]) study: A single-blind, randomised controlled trial.

Can listening-related fatigue influence well-being? Examining associations between hearing loss, fatigue, activity levels and well-being (2021)
Journal Article
Holman, J. A., Hornsby, B. W. Y., Bess, F. H., & Naylor, G. (2021). Can listening-related fatigue influence well-being? Examining associations between hearing loss, fatigue, activity levels and well-being. International Journal of Audiology, 60(sup2), 47-59. https://doi.org/10.1080/14992027.2020.1853261

Objective Well-being is influenced by the activities we undertake. Hearing loss may reduce well-being directly through increased listening-related fatigue due to cognitive and emotional strain in challenging situations. Hearing loss and hearing devi... Read More about Can listening-related fatigue influence well-being? Examining associations between hearing loss, fatigue, activity levels and well-being.

A new hypothesis for the origin of Amazonian Dark Earths (2021)
Journal Article
Silva, L. C., Corrêa, R. S., Wright, J. L., Bomfim, B., Hendricks, L., Gavin, D. G., …Santos, R. V. (2021). A new hypothesis for the origin of Amazonian Dark Earths. Nature Communications, 12(1), https://doi.org/10.1038/s41467-020-20184-2

Amazonian Dark Earths (ADEs) are unusually fertile soils characterised by elevated concentrations of microscopic charcoal particles, which confer their distinctive colouration. Frequent occurrences of pre-Columbian artefacts at ADE sites led to their... Read More about A new hypothesis for the origin of Amazonian Dark Earths.

Advanced analysis of satellite data reveals ground deformation precursors to the Brumadinho Tailings Dam collapse (2021)
Journal Article
Grebby, S., Sowter, A., Gluyas, J., Toll, D., Gee, D., Athab, A., & Girindran, R. (2021). Advanced analysis of satellite data reveals ground deformation precursors to the Brumadinho Tailings Dam collapse. Communications Earth & Environment, 2, Article 2. https://doi.org/10.1038/s43247-020-00079-2

Catastrophic failure of a tailings dam at an iron ore mine complex in Brumadinho, Brazil, on 25th January 2019 released 11.7 million m3 of tailings downstream. Although reportedly monitored using an array of geotechnical techniques, the collapse occu... Read More about Advanced analysis of satellite data reveals ground deformation precursors to the Brumadinho Tailings Dam collapse.

Compositional, thermal and water sorption properties of wheat flour: comparing wild-relatives v/s elite wheat varieties used in current plant breeding (2021)
Journal Article
Agarwal, D., MacNaughtan, W., King, J., & Foster, T. J. (2021). Compositional, thermal and water sorption properties of wheat flour: comparing wild-relatives v/s elite wheat varieties used in current plant breeding. Food and Function, 12(2), 781-790. https://doi.org/10.1039/d0fo02223c

Plant breeders are focused on creating new varieties of wheat with enhanced yield potential without affecting the quality of wheat for food. In this study, four cultivated varieties of wheat, Triticium asetivum and two wild relatives of wheat; Tritic... Read More about Compositional, thermal and water sorption properties of wheat flour: comparing wild-relatives v/s elite wheat varieties used in current plant breeding.

Community Occupational Therapy for people with dementia and family carers (COTiD-UK) versus treatment as usual (Valuing Active Life in Dementia [VALID]) study: a single-blind, randomised controlled trial (2021)
Journal Article
Wenborn, J., O'Keeffe, A. G., Mountain, G., Moniz-Cook, E., King, M., Omar, R. Z., …Orrell, M. (2021). Community Occupational Therapy for people with dementia and family carers (COTiD-UK) versus treatment as usual (Valuing Active Life in Dementia [VALID]) study: a single-blind, randomised controlled trial. PLoS Medicine, 18(1), Article e1003433. https://doi.org/10.5522/04/13084151

Background We aimed to estimate the clinical effectiveness of Community Occupational Therapy for people with dementia and family carers–UK version (Community Occupational Therapy in Dementia–UK version [COTiD-UK]) relative to treatment as usual (T... Read More about Community Occupational Therapy for people with dementia and family carers (COTiD-UK) versus treatment as usual (Valuing Active Life in Dementia [VALID]) study: a single-blind, randomised controlled trial.

Recommended core outcome instruments for health‐related quality of life, long‐term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting (2021)
Journal Article
Thomas, K., Apfelbacher, C., Chalmers, J., Simpson, E., Spuls, P., Gerbens, L., …Katoh, N. (2021). Recommended core outcome instruments for health‐related quality of life, long‐term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting. British Journal of Dermatology, 185(1), 139-146. https://doi.org/10.1111/bjd.19751

Background: The Harmonising Outcome Measures for Eczema (HOME) initiative has established a core outcome set of domains for atopic eczema (AE) clinical trials. Previous consensus meetings have agreed on preferred instruments for clinician-reported si... Read More about Recommended core outcome instruments for health‐related quality of life, long‐term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting.

Emergence and control of complex behaviors in driven systems of interacting qubits with dissipation (2021)
Journal Article
Andreev, A. V., Balanov, A. G., Fromhold, T. M., Greenaway, M. T., Hramov, A. E., Li, W., …Zagoskin, A. M. (2021). Emergence and control of complex behaviors in driven systems of interacting qubits with dissipation. npj Quantum Information, 7(1), Article 1. https://doi.org/10.1038/s41534-020-00339-1

Progress in the creation of large scale, artificial quantum coherent structures demands the investigation of their nonequilibrium dynamics when strong interactions, even between remote parts, are non-perturbative. Analysis of multiparticle quantum co... Read More about Emergence and control of complex behaviors in driven systems of interacting qubits with dissipation.

Quantum computing at the frontiers of biological sciences (2021)
Journal Article
Emani, P. S., Warrell, J., Anticevic, A., Bekiranov, S., Gandal, M., McConnell, M. J., …Harrow, A. W. (2021). Quantum computing at the frontiers of biological sciences. Nature Methods, 18, 701-709. https://doi.org/10.1038/s41592-020-01004-3

The search for meaningful structure in biological data has relied on cutting-edge advances in computational technology and data science methods. However, challenges arise as we push the limits of scale and complexity in biological problems. Innovatio... Read More about Quantum computing at the frontiers of biological sciences.

Autism and the double empathy problem: Implications for development and mental health (2021)
Journal Article
Mitchell, P., Sheppard, E., & Cassidy, S. (2021). Autism and the double empathy problem: Implications for development and mental health. British Journal of Developmental Psychology, 39(1), 1-18. https://doi.org/10.1111/bjdp.12350

Autism and the double empathy problem: Implications for development and mental health This article explores how the experience of living in a largely neurotypical society could hinder development of abilities which allow smooth interactions between a... Read More about Autism and the double empathy problem: Implications for development and mental health.

English version of the food disgust scale: Optimization and other considerations (2021)
Journal Article
Thibodeau, M., Yang, Q., Ford, R., & Pickering, G. (2021). English version of the food disgust scale: Optimization and other considerations. Journal of Sensory Studies, 36(2), Article e12639. https://doi.org/10.1111/joss.12639

© 2021 Wiley Periodicals LLC. The disgust elicited by food plays an important role in food choice and consumption. Recently, Hartmann and Siegrist (Food Quality and Preference, 2018, 63, 38–50) developed and validated in German the food disgust scale... Read More about English version of the food disgust scale: Optimization and other considerations.

Vibrations of pyrrole, N-substituted pyrroles, and their cations (2021)
Journal Article
Davies, A. R., Kemp, D. J., & Wright, T. G. (2021). Vibrations of pyrrole, N-substituted pyrroles, and their cations. Journal of Molecular Spectroscopy, 376, Article 111410. https://doi.org/10.1016/j.jms.2020.111410

The vibrations of pyrrole, N-deuteropyrrole, N-fluoropyrrole, N-aminopyrrole and N-methylpyrrole are studied. The evolution of the vibrational wavenumbers of pyrrole is examined, as the mass of the nitrogen-bonded hydrogen atom is artificially increa... Read More about Vibrations of pyrrole, N-substituted pyrroles, and their cations.

Improving the Strategy of Maintaining Offshore Wind Turbines through Petri Net Modelling (2021)
Journal Article
Yan, R., & Dunnett, S. (2021). Improving the Strategy of Maintaining Offshore Wind Turbines through Petri Net Modelling. Applied Sciences, 11(2), Article 574. https://doi.org/10.3390/app11020574

In order to improve the operation and maintenance (O&M) of offshore wind turbines, a new Petri net (PN)-based offshore wind turbine maintenance model is developed in this paper to simulate the O&M activities in an offshore wind farm. With the aid of... Read More about Improving the Strategy of Maintaining Offshore Wind Turbines through Petri Net Modelling.

Assessment of Cannabidiol and ?9-Tetrahydrocannabiol in Mouse Models of Medulloblastoma and Ependymoma (2021)
Journal Article
Andradas, C., Byrne, J., Kuchibhotla, M., Ancliffe, M., Jones, A. C., Carline, B., …Endersby, R. (2021). Assessment of Cannabidiol and ∆9-Tetrahydrocannabiol in Mouse Models of Medulloblastoma and Ependymoma. Cancers, 13, Article 330. https://doi.org/10.3390/cancers13020330

Children with medulloblastoma and ependymoma are treated with a multidisciplinary approach that incorporates surgery, radiotherapy, and chemotherapy; however, overall survival rates for patients with high-risk disease remain unsatisfactory. Data indi... Read More about Assessment of Cannabidiol and ?9-Tetrahydrocannabiol in Mouse Models of Medulloblastoma and Ependymoma.

Near-ultraviolet circular dichroism and two-dimensional spectroscopy of polypeptides (2021)
Journal Article
Segatta, F., Rogers, D. M., Dyer, N. T., Guest, E. E., Li, Z., Do, H., …Hirst, J. D. (2021). Near-ultraviolet circular dichroism and two-dimensional spectroscopy of polypeptides. Molecules, 26(2), Article 396. https://doi.org/10.3390/MOLECULES26020396

A fully quantitative theory of the relationship between protein conformation and optical spectroscopy would facilitate deeper insights into biophysical and simulation studies of protein dynamics and folding. In contrast to intense bands in the far-ul... Read More about Near-ultraviolet circular dichroism and two-dimensional spectroscopy of polypeptides.

A Genetic Optimization Resampling Based Particle Filtering Algorithm for Indoor Target Tracking (2021)
Journal Article
Zhou, N., Lau, L., Bai, R., & Moore, T. (2021). A Genetic Optimization Resampling Based Particle Filtering Algorithm for Indoor Target Tracking. Remote Sensing, 13(1), Article 132. https://doi.org/10.3390/rs13010132

In indoor target tracking based on wireless sensor networks, the particle filtering algorithm has been widely used because of its outstanding performance in coping with highly non-linear problems. Resampling is generally required to address the inher... Read More about A Genetic Optimization Resampling Based Particle Filtering Algorithm for Indoor Target Tracking.

Inclusion of Wheat Dried Distillers’ Grains with Solubles from Bioethanol Plants in Diets for Dairy Cows (2021)
Journal Article
Garnsworthy, P. C., Marsden, M., Goodman, J. R., & Saunders, N. (2021). Inclusion of Wheat Dried Distillers’ Grains with Solubles from Bioethanol Plants in Diets for Dairy Cows. Animals, 11(1), Article 70. https://doi.org/10.3390/ani11010070

Dried distillers’ grains with solubles (DDGS) from bioethanol production can replace soya in diets for dairy cows, but optimum inclusion level of European wheat-DDGS (wDDGS) is unknown. Two batches of wDDGS from different UK bioethanol plants were fe... Read More about Inclusion of Wheat Dried Distillers’ Grains with Solubles from Bioethanol Plants in Diets for Dairy Cows.

Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients (2021)
Journal Article
Izquierdo, E., Proszek, P., Pericoli, G., Temelso, S., Clarke, M., Carvalho, D. M., …Jones, C. (2021). Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients. Neuro-Oncology Advances, 3(1), Article vdab013. https://doi.org/10.1093/noajnl/vdab013

Background The use of liquid biopsy is of potential high importance for children with high grade (HGG) and diffuse midline gliomas (DMG), particularly where surgical procedures are limited, and invasive biopsy sampling not without risk. To date, how... Read More about Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients.

ERS international congress 2020: Highlights from the paediatric assembly (2021)
Journal Article
Ardura-Garcia, C., Cuevas-Ocaña, S., Freitag, N., Kampouras, A., King, J. A., Kouis, P., …Pijnenburg, M. W. (2021). ERS international congress 2020: Highlights from the paediatric assembly. ERJ Open Research, 7(1), Article 00893-2020. https://doi.org/10.1183/23120541.00893-2020

In this review, the Paediatric Assembly of the European Respiratory Society (ERS) presents a summary of the highlights and most relevant findings in the field of paediatric respiratory medicine presented at the virtual ERS International Congress 2020... Read More about ERS international congress 2020: Highlights from the paediatric assembly.