All Outputs (4021)

Weak Acid Resistance A (WarA), a Novel Transcription Factor Required for Regulation of Weak-Acid Resistance and Spore-Spore Heterogeneity in Aspergillus niger (2020)
Journal Article

Copyright © 2020 Geoghegan et al. Propionic, sorbic, and benzoic acids are organic weak acids that are widely used as food preservatives, where they play a critical role in preventing microbial growth. In this study, we uncovered new mechanisms of we... Read More about Weak Acid Resistance A (WarA), a Novel Transcription Factor Required for Regulation of Weak-Acid Resistance and Spore-Spore Heterogeneity in Aspergillus niger.

Randomised, double-blind, multicentre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B feasibility) (2020)
Journal Article

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. New treatments are required for severe breathlessness in advanced disease. We conducted a randomised feasibility trial of mirtazapine over 28 days in adults with... Read More about Randomised, double-blind, multicentre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B feasibility).

Mortality in children and adolescents following presentation to hospital after non-fatal self-harm in the Multicentre Study of Self-harm: a prospective observational cohort study (2020)
Journal Article

© 2020 Elsevier Ltd Background: Self-harm and suicide in children and adolescents are growing problems, and self-harm is associated with a significant risk of subsequent death, particularly suicide. Long-term follow-up studies are necessary to examin... Read More about Mortality in children and adolescents following presentation to hospital after non-fatal self-harm in the Multicentre Study of Self-harm: a prospective observational cohort study.

Bayesian protein sequence and structure alignment (2020)
Journal Article

© 2020 Royal Statistical Society The structure of a protein is crucial in determining its functionality and is much more conserved than sequence during evolution. A key task in structural biology is to compare protein structures to determine evolutio... Read More about Bayesian protein sequence and structure alignment.

Combining EPS geofoam with geocell to reduce buried pipe loads and trench surface rutting (2020)
Journal Article

© 2020 Elsevier Ltd This paper reports full scale experiments, under simulated heavy traffic, of geocell and EPS (expanded polystyrene) geofoam block inclusions to mitigate the pressure on, and deformation of, shallow buried, high density polyethylen... Read More about Combining EPS geofoam with geocell to reduce buried pipe loads and trench surface rutting.

Network analysis of human muscle adaptation to aging and contraction (2020)
Journal Article

Resistance exercise (RE) remains a primary approach for minimising aging muscle decline. Understanding muscle adaptation to individual contractile components of RE (eccentric, concentric) might optimise RE-based intervention strategies. Herein, we em... Read More about Network analysis of human muscle adaptation to aging and contraction.

Overcoming technical barriers to brewing with green (non-kilned) malt: a feasibility study (2020)
Journal Article

Brewing using enzyme rich ‘green’ (germinated, but not kilned) malt has the potential to unlock considerable energy savings in the malting and brewing chain. This paper examines the major quality issues associated with green malt, by monitoring lipox... Read More about Overcoming technical barriers to brewing with green (non-kilned) malt: a feasibility study.

Strategic planning and place branding in a World Heritage cultural landscape: a case study of the English Lake District, UK (2020)
Journal Article

What roles do strategic planning and place branding play in the context of UNESCO World Heritage Sites (WHS)? Here it is theorized that the processes associated with the nomination and management of WHS cultural landscapes involve an integration of p... Read More about Strategic planning and place branding in a World Heritage cultural landscape: a case study of the English Lake District, UK.

Microstructure and mechanical properties of fibre reinforced asphalt mixtures (2020)
Journal Article

Conventional asphalt mixtures can perform satisfactorily in most flexible pavement and airfield applications. However, during recent years the trend has been towards traffic growth, severe climate conditions, and heavier loads. This allied to durabil... Read More about Microstructure and mechanical properties of fibre reinforced asphalt mixtures.

A novel stable isotope tracer method to simultaneously quantify skeletal muscle protein synthesis and breakdown (2020)
Journal Article

Background/Aims: Methodological challenges have been associated with the dynamic measurement of muscle protein breakdown (MPB), as have the measurement of both muscle protein synthesis (MPS) and MPB within the same experiment. Our aim was to use the... Read More about A novel stable isotope tracer method to simultaneously quantify skeletal muscle protein synthesis and breakdown.

Cross-country spillovers from macroprudential regulation: Reciprocity and leakage (2020)
Journal Article

In a globally interconnected banking system, there can be spillovers from domestic macroprudential policies to foreign banks and vice versa, for example, through the presence of foreign branches in the domestic economy. The lack of reciprocity of som... Read More about Cross-country spillovers from macroprudential regulation: Reciprocity and leakage.

Political lives at sea: working and socialising to and from the India Round Table Conference in London, 1930–1932 (2020)
Journal Article

This paper presents new ways of thinking about both the spatial relationality of a political event, and a mobile perspective on interwar imperialism, anti-colonialism and Indian nationalism. Between 1930 and 1932 over one hundred delegates from India... Read More about Political lives at sea: working and socialising to and from the India Round Table Conference in London, 1930–1932.

Truthmaker Semantics for Relevant Logic (2020)
Journal Article

I develop and defend a truthmaker semantics for the relevant logic R. The approach begins with a simple philosophical idea and develops it in various directions, so as to build a technically adequate relevant semantics. The central philosophical idea... Read More about Truthmaker Semantics for Relevant Logic.

Electric drive systems with long feeder cables (2020)
Journal Article

Electric drive systems with long feeder cables connecting inverter and machine are used for oil exploration, mining, remote operated vehicles, industrial, and aerospace applications. Though this topology has the advantage of providing a better operat... Read More about Electric drive systems with long feeder cables.

Dual predation by bacteriophage and bdellovibrio bacteriovorus can eradicate escherichia coli prey in situations where single predation cannot (2020)
Journal Article

Copyright © 2020 Hobley et al. Bacteria are preyed upon by diverse microbial predators, including bacteriophage and predatory bacteria, such as Bdellovibrio bacteriovorus. While bacteriophage are used as antimicrobial therapies in Eastern Europe and... Read More about Dual predation by bacteriophage and bdellovibrio bacteriovorus can eradicate escherichia coli prey in situations where single predation cannot.

Development and Fidelity Testing of the Test@Work Digital Toolkit for Employers on Workplace Health Checks and Opt-In HIV Testing (2020)
Journal Article

BACKGROUND: In the UK, few employers offer general health checks for employees, and opt-in HIV testing is rarely included. There is a need to provide evidence-based guidance and support for employers around health checks and HIV testing in the workpl... Read More about Development and Fidelity Testing of the Test@Work Digital Toolkit for Employers on Workplace Health Checks and Opt-In HIV Testing.

Novel roles of dense granule protein 12 (GRA12) in Toxoplasma gondii infection (2020)
Journal Article

Genetic Variation: Harmful Recessive Mutations Have Unexpected Effects on Variation (2020)
Journal Article

© 2019 Elsevier Ltd New data are causing the standard model for the effect of selection on linked neutral variation in low recombination regions, combining the effects of background selection and selective sweeps, to be refined to include harmful rec... Read More about Genetic Variation: Harmful Recessive Mutations Have Unexpected Effects on Variation.

Grain Reynolds number scale effects in dry granular slides (2020)
Journal Article

©2020. The Authors. Scale effects are differences in physical behavior that manifest between a large event and a geometrically scaled laboratory model and may cause misleading predictions. This study focuses on scale effects in granular slides, impor... Read More about Grain Reynolds number scale effects in dry granular slides.

Postoperative pain management: time to get back on track (2020)
Journal Article