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Upper GI biopsies for adenocarcinoma: how many biopsies should endoscopists take? (2018)
Journal Article
Kaye, P., Lindsay, D., Madhusudan, S., Vohra, R., Catton, J., Platt, C., & Ragunath, K. (2019). Upper GI biopsies for adenocarcinoma: how many biopsies should endoscopists take?. Histopathology, 74(6), 959-963. doi:10.1111/his.13816

Aims: There is evidence that 4 or 5 gastric cancer biopsies are required for accurate HER2 interpretation. However, the number of biopsies that need to be taken to reach this number of viable cancer biopsies is without evidence. This study aimed to a... Read More about Upper GI biopsies for adenocarcinoma: how many biopsies should endoscopists take?.

Prevalence and impact of self-reported irritable bowel symptoms in the general population (2018)
Journal Article
Van den Houte, K., Carbone, F., Pannemans, J., Corsetti, M., Fischler, B., Piessevaux, H., & Tack, J. (2019). Prevalence and impact of self-reported irritable bowel symptoms in the general population. United European Gastroenterology Journal, 7(2), 307-315. doi:10.1177/2050640618821804

Background and aims The symptom-based diagnostic criteria for irritable bowel syndrome (IBS) have recently been revised in the Rome IV consensus. On the other hand, with rising public awareness of IBS, self-diagnosis and self-management is also incr... Read More about Prevalence and impact of self-reported irritable bowel symptoms in the general population.

SOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosis (2018)
Journal Article
Guha, I. N., Hanley, N. A., Friedman, S. L., Zeef, L. A. H., Mullan, A. F., Zaitoun, A. M., …Hanley, K. P. (2018). SOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosis. Scientific Reports, 8(1), https://doi.org/10.1038/s41598-018-36037-4

Extracellular matrix (ECM) deposition and resultant scar play a major role in the pathogenesis and progression of liver fibrosis. Identifying core regulators of ECM deposition may lead to urgently needed diagnostic and therapetic strategies for the d... Read More about SOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosis.

The role of oral antibiotic preparation in elective colorectal surgery: a meta-analysis (2018)
Journal Article
Rollins, K. E., Javanmard-Emamghissi, H., Acheson, A. G., & Lobo, D. N. (2019). The role of oral antibiotic preparation in elective colorectal surgery: a meta-analysis. Annals of Surgery, 270(1), 43–58. doi:10.1097/SLA.0000000000003145

Objectives: To compare the impact of the use of oral antibiotics (OAB) with or without mechanical bowel preparation (MBP) on outcome in elective colorectal surgery. Summary Background Data: Meta-analyses have demonstrated that MBP does not impact... Read More about The role of oral antibiotic preparation in elective colorectal surgery: a meta-analysis.

Short-term changes observed in multi-parametric liver MRI following therapy with direct acting antivirals in chronic hepatitis C virus patients (2018)
Journal Article
Bradley, C., Scott, R., Cox, E., Palaniyappan, N., Thompson, B., Ryder, D., …Francis, S. (2019). Short-term changes observed in multi-parametric liver MRI following therapy with direct acting antivirals in chronic hepatitis C virus patients. European Radiology, 29(6), 3100–3107. doi:10.1007/s00330-018-5788-1

Methods: We applied multiparametric MRI to assess changes in liver composition, perfusion and blood flow in 17 patients before DAA therapy and after treatment completion (within 12 weeks of last DAA tablet swallowed). Results: We observed changes in... Read More about Short-term changes observed in multi-parametric liver MRI following therapy with direct acting antivirals in chronic hepatitis C virus patients.

Acetarsol in the management of mesalazine refractory ulcerative proctitis: a tertiary-level care experience (2018)
Journal Article
Argyriou, K., Samuel, S., & Moran, G. W. (2019). Acetarsol in the management of mesalazine refractory ulcerative proctitis: a tertiary-level care experience. European Journal of Gastroenterology and Hepatology, 31(2), 183–186. doi:10.1097/MEG.0000000000001326

Background and Aims: Mesalazine-refractory ulcerative proctitis is common, with a significant proportion of the patients requiring escalation to immunomodulators or biological therapy. Three small preliminary cohort studies suggested good clinica... Read More about Acetarsol in the management of mesalazine refractory ulcerative proctitis: a tertiary-level care experience.

Guidelines for perioperative care in elective colorectal surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations: 2018 (2018)
Journal Article
Gustafsson, U., Scott, M., Hubner, M., Nygren, J., Demartines, N., Francis, N., …Ljungqvist, O. (2018). Guidelines for perioperative care in elective colorectal surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations: 2018. World Journal of Surgery, doi:10.1007/s00268-018-4844-y

Background: This is the fourth updated Enhanced Recovery After Surgery (ERAS®) Society guideline presenting a consensus for optimal perioperative care in colorectal surgery and providing graded recommendations for each ERAS item within the ERAS® prot... Read More about Guidelines for perioperative care in elective colorectal surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations: 2018.

Association of Pretransplant Renal Function With Liver Graft and Patient Survival After Liver Transplantation in Patients With Nonalcoholic Steatohepatitis (2018)
Journal Article
Molnar, M. Z., Joglekar, K., Jiang, Y., Cholankeril, G., Abdul, M. K. M., Kedia, S., …Satapathy, S. K. (2019). Association of Pretransplant Renal Function With Liver Graft and Patient Survival After Liver Transplantation in Patients With Nonalcoholic Steatohepatitis. Liver Transplantation, 25(3), 399-410. doi:10.1002/lt.25367

Background: Nonalcoholic Steatohepatitis(NASH) is one of the top three indications for liver transplantation in western countries. It is unknown whether renal dysfunction at the time of liver transplantation has any effect on post-liver transplantati... Read More about Association of Pretransplant Renal Function With Liver Graft and Patient Survival After Liver Transplantation in Patients With Nonalcoholic Steatohepatitis.

Time to endoscopy for acute upper gastrointestinal bleeding: results from a prospective multicentre trainee-led audit (2018)
Journal Article
Siau, K., Hodson, J., Ingram, R., Baxter, A., Widlak, M. M., Sharratt, C., …Major, G. (2018). Time to endoscopy for acute upper gastrointestinal bleeding: results from a prospective multicentre trainee-led audit. United European Gastroenterology Journal, doi:10.1177/2050640618811491

Background: Endoscopy within 24 hours of admission (early endoscopy) is a quality standard in acute upper gastrointestinal bleeding (AUGIB). We aimed to audit time to endoscopy outcomes and identify factors affecting delayed endoscopy (>24h of admiss... Read More about Time to endoscopy for acute upper gastrointestinal bleeding: results from a prospective multicentre trainee-led audit.

Identification of Cystic Lesions by Secondary Screening of Familial Pancreatic Cancer (FPC) Kindreds Is Not Associated with the Stratified Risk of Cancer (2018)
Journal Article
Sheel, A. R. G., Harrison, S., Sarantitis, I., Nicholson, J. A., Hanna, T., Grocock, C., …Greenhalf, W. (2019). Identification of Cystic Lesions by Secondary Screening of Familial Pancreatic Cancer (FPC) Kindreds Is Not Associated with the Stratified Risk of Cancer. American Journal of Gastroenterology, 114(1), 155-164. https://doi.org/10.1038/s41395-018-0395-y

Objectives: Intraductal Papillary Mucinous Neoplasms (IPMNs) are associated with risk of pancreatic ductal adenocarcinoma (PDAC). It is unclear if an IPMN in individuals at high risk of PDAC should be considered as a positive screening result or as... Read More about Identification of Cystic Lesions by Secondary Screening of Familial Pancreatic Cancer (FPC) Kindreds Is Not Associated with the Stratified Risk of Cancer.

The risk of venous thromboembolism during and after hospitalisation in patients with inflammatory bowel disease activity (2018)
Journal Article
Chu, T. P. C., Grainge, M. J., & Card, T. R. (2018). The risk of venous thromboembolism during and after hospitalisation in patients with inflammatory bowel disease activity. Alimentary Pharmacology and Therapeutics, 48(10), 1099-1108. doi:10.1111/apt.15010

Background: Inflammatory bowel disease (IBD) increases the risk of venous thromboembolism. Aim: To determine when patients are at high risk of thromboembolic events, including after major surgery, and to guide timing of thromboprophylaxis. Methods:... Read More about The risk of venous thromboembolism during and after hospitalisation in patients with inflammatory bowel disease activity.

Pharmacokinetics and safety of fidaxomicin in patients with inflammatory bowel disease and Clostridium difficile infection: an open-label Phase IIIb/IV study (PROFILE) (2018)
Journal Article
Mahida, Y., Stallmach, A., Marteau, P., Rydzewska, G., Ivashkin, V., Gargalianos-Kakolyris, P., …Högenauer, C. (2018). Pharmacokinetics and safety of fidaxomicin in patients with inflammatory bowel disease and Clostridium difficile infection: an open-label Phase IIIb/IV study (PROFILE). Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dky368. ISSN 0305-7453

Objectives Inflammatory bowel disease (IBD) poses an increased risk for Clostridium difficile infection (CDI). Fidaxomicin has demonstrated non-inferiority to vancomycin for initial clinical cure of CDI in patients without IBD; however, lack of data... Read More about Pharmacokinetics and safety of fidaxomicin in patients with inflammatory bowel disease and Clostridium difficile infection: an open-label Phase IIIb/IV study (PROFILE).

Changing autonomy in operative experience through UK general surgery training: a national cohort study (2018)
Journal Article
Elsey, E. J., Griffiths, G., West, J., & Humes, D. J. (2019). Changing autonomy in operative experience through UK general surgery training: a national cohort study. Annals of Surgery, 269(3), 399-406. doi:10.1097/sla.0000000000003032

Objectives:To determine the operative experience of UK general surgery trainees and assess the changing procedural supervision and acquisition of competency assessments through the course of training. Background Summary Data: Competency assessment... Read More about Changing autonomy in operative experience through UK general surgery training: a national cohort study.

MRI assessment of altered dynamic changes in liver haemodynamics following a meal challenge in compensated cirrhosis (2018)
Journal Article
Cox, E. F., Palaniyappan, N., Aithal, G. P., Guha, I. N., & Francis, S. T. (2018). MRI assessment of altered dynamic changes in liver haemodynamics following a meal challenge in compensated cirrhosis. European Radiology Experimental, 2, doi:10.1186/s41747-018-0056-3. ISSN 2509-9280

Background: To use magnetic resonance imaging (MRI) to dynamically assess postprandial changes in hepatic and collateral blood flow, liver perfusion and oxygenation in healthy participants and patients with liver disease with compensated cirrhosis (C... Read More about MRI assessment of altered dynamic changes in liver haemodynamics following a meal challenge in compensated cirrhosis.

Follow-on RifAximin for the prevention of recurrence following standard treatment of infection with Clostridium difficile (RAPID): a randomised placebo controlled trial (2018)
Journal Article
Major, G., Bradshaw, L., Boota, N., Sprange, K., Diggle, M., Montgomery, A., …Spiller, R. (2018). Follow-on RifAximin for the prevention of recurrence following standard treatment of infection with Clostridium difficile (RAPID): a randomised placebo controlled trial. Gut, doi:10.1136/gutjnl-2018-316794. ISSN 0017-5749

Background Clostridium difficile infection (CDI) recurs after initial treatment in approximately one in four patients. A single-centre pilot study suggested that this could be reduced using ‘follow-on’ rifaximin treatment. We aimed to assess the effi... Read More about Follow-on RifAximin for the prevention of recurrence following standard treatment of infection with Clostridium difficile (RAPID): a randomised placebo controlled trial.

Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway (2018)
Journal Article
Monaghan, T. M., Mullish, B. H., Patterson, J., Wong, G. K., Marchesi, J. R., Xu, H., …Kao, D. (2018). Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway. Gut Microbes, doi:10.1080/19490976.2018.1506667. ISSN 1949-0976

The mechanisms of efficacy for fecal microbiota# transplantation (FMT) in treating recurrent Clostridioides difficile infection (rCDI) remain poorly defined, with restored gut microbiota-bile acid interactions representing one possible explanation. F... Read More about Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway.

Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders? (2018)
Journal Article
Pannemans, J., & Corsetti, M. (2018). Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?. Current Opinion in Pharmacology, 43, 53-58. doi:10.1016/j.coph.2018.08.008

Opioids have been used for centuries, mostly as a sedative and to treat pain. Currently, they are used on a global scale for the treatment of acute and chronic pain in diseases as osteoarthritis, fibromyalgia, and low back pain. Binding of opioids on... Read More about Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?.